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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 352

FusionGeneSummary for ACAP2_UBE2J2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACAP2_UBE2J2
Fusion gene ID: 352
HgeneTgene
Gene symbol

ACAP2

UBE2J2

Gene ID

23527

118424

Gene nameArfGAP with coiled-coil, ankyrin repeat and PH domains 2ubiquitin conjugating enzyme E2 J2
SynonymsCENTB2|CNT-B2NCUBE-2|NCUBE2|PRO2121
Cytomap

3q29

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2ubiquitin-conjugating enzyme E2 J2E2 ubiquitin-conjugating enzyme J2non-canonical ubiquitin-conjugating enzyme 2ubiquitin conjugating enzyme 6ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)yeast UBC6 homolog
Modification date2018052320180523
UniProtAcc

Q15057

Q8N2K1

Ensembl transtripts involved in fusion geneENST00000326793, ENST00000472860, 
ENST00000347370, ENST00000349431, 
ENST00000339385, ENST00000348298, 
ENST00000400929, ENST00000360466, 
ENST00000400930, ENST00000491779, 
Fusion gene scores* DoF score9 X 7 X 10=6306 X 5 X 2=60
# samples 136
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: ACAP2 [Title/Abstract] AND UBE2J2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EY-A3QX-01AACAP2chr3

195101738

-UBE2J2chr1

1203372

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000326793ENST00000347370ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-5UTRENST00000326793ENST00000349431ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-intronENST00000326793ENST00000339385ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-5UTRENST00000326793ENST00000348298ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-intronENST00000326793ENST00000400929ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-intronENST00000326793ENST00000360466ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-intronENST00000326793ENST00000400930ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
5CDS-intronENST00000326793ENST00000491779ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-5UTRENST00000472860ENST00000347370ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-5UTRENST00000472860ENST00000349431ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-intronENST00000472860ENST00000339385ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-5UTRENST00000472860ENST00000348298ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-intronENST00000472860ENST00000400929ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-intronENST00000472860ENST00000360466ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-intronENST00000472860ENST00000400930ACAP2chr3

195101738

-UBE2J2chr1

1203372

-
intron-intronENST00000472860ENST00000491779ACAP2chr3

195101738

-UBE2J2chr1

1203372

-

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FusionProtFeatures for ACAP2_UBE2J2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACAP2

Q15057

UBE2J2

Q8N2K1

GTPase-activating protein (GAP) for ADP ribosylationfactor 6 (ARF6). {ECO:0000269|PubMed:11062263}. Catalyzes the covalent attachment of ubiquitin to otherproteins. Seems to function in the selective degradation ofmisfolded membrane proteins from the endoplasmic reticulum (ERAD).{ECO:0000255|PROSITE-ProRule:PRU00388}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACAP2_UBE2J2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACAP2_UBE2J2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACAP2SMURF1, HSPB1, RAB11FIP3, MED4, PDK3, SOAT1, NDUFS1, NDUFA9, PIGS, MBOAT7, EHBP1, GDI1, GPAA1, CYLDUBE2J2XIAP, MGRN1, RNF10, TRIM25, PARK2, UBC, ATP13A2, HERC4, NEDD4L, WWP2, ITCH, UBE2J2, TMEM129, HECW1, RNF185, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACAP2_UBE2J2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACAP2_UBE2J2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource