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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3516

FusionGeneSummary for ATP9A_ATP9A

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP9A_ATP9A
Fusion gene ID: 3516
HgeneTgene
Gene symbol

ATP9A

ATP9A

Gene ID

10079

10079

Gene nameATPase phospholipid transporting 9A (putative)ATPase phospholipid transporting 9A (putative)
SynonymsATPIIAATPIIA
Cytomap

20q13.2

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIAprobable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIA
Modification date2018052320180523
UniProtAcc

O75110

O75110

Ensembl transtripts involved in fusion geneENST00000311637, ENST00000338821, 
ENST00000402822, ENST00000477492, 
ENST00000311637, ENST00000338821, 
ENST00000402822, ENST00000477492, 
Fusion gene scores* DoF score9 X 8 X 7=5047 X 6 X 6=252
# samples 97
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP9A [Title/Abstract] AND ATP9A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF933640ATP9Achr20

50307360

+ATP9Achr20

50273476

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000311637ENST00000311637ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000311637ENST00000338821ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000311637ENST00000402822ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000311637ENST00000477492ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000338821ENST00000311637ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000338821ENST00000338821ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000338821ENST00000402822ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000338821ENST00000477492ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000402822ENST00000311637ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000402822ENST00000338821ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000402822ENST00000402822ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000402822ENST00000477492ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000477492ENST00000311637ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000477492ENST00000338821ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000477492ENST00000402822ATP9Achr20

50307360

+ATP9Achr20

50273476

+
intron-intronENST00000477492ENST00000477492ATP9Achr20

50307360

+ATP9Achr20

50273476

+

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FusionProtFeatures for ATP9A_ATP9A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP9A

O75110

ATP9A

O75110


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP9A_ATP9A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP9A_ATP9A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP9A_ATP9A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP9A_ATP9A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource