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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35148

FusionGeneSummary for SNHG6_NQO1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG6_NQO1
Fusion gene ID: 35148
HgeneTgene
Gene symbol

SNHG6

NQO1

Gene ID

641638

1728

Gene namesmall nucleolar RNA host gene 6NAD(P)H quinone dehydrogenase 1
SynonymsHBII-276HG|NCRNA00058|U87HGDHQU|DIA4|DTD|NMOR1|NMORI|QR1
Cytomap

8q13.1|8q13

16q22.1

Type of genencRNAprotein-coding
DescriptionHBII-276 hostU87 hostsmall nucleolar RNA host gene (non-protein coding) 6NAD(P)H dehydrogenase [quinone] 1DT-diaphoraseNAD(P)H dehydrogenase, quinone 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/
Modification date2018040220180523
UniProtAcc

P15559

Ensembl transtripts involved in fusion geneENST00000364849, ENST00000561500, 
ENST00000379047, ENST00000320623, 
ENST00000379046, ENST00000439109, 
ENST00000564043, 
Fusion gene scores* DoF score7 X 5 X 3=1054 X 5 X 2=40
# samples 75
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNHG6 [Title/Abstract] AND NQO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA648735SNHG6chr8

67834709

-NQO1chr16

69760463

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000364849ENST00000561500SNHG6chr8

67834709

-NQO1chr16

69760463

-
intron-5UTRENST00000364849ENST00000379047SNHG6chr8

67834709

-NQO1chr16

69760463

-
intron-5UTRENST00000364849ENST00000320623SNHG6chr8

67834709

-NQO1chr16

69760463

-
intron-5UTRENST00000364849ENST00000379046SNHG6chr8

67834709

-NQO1chr16

69760463

-
intron-5UTRENST00000364849ENST00000439109SNHG6chr8

67834709

-NQO1chr16

69760463

-
intron-5UTRENST00000364849ENST00000564043SNHG6chr8

67834709

-NQO1chr16

69760463

-

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FusionProtFeatures for SNHG6_NQO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNHG6

NQO1

P15559

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. The enzyme apparently serves as a quinone reductase inconnection with conjugation reactions of hydroquinons involved indetoxification pathways as well as in biosynthetic processes suchas the vitamin K-dependent gamma-carboxylation of glutamateresidues in prothrombin synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNHG6_NQO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNHG6_NQO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNHG6_NQO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNQO1P15559DB00266DicoumarolNAD(P)H dehydrogenase [quinone] 1small moleculeapproved
TgeneNQO1P15559DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1small moleculeapproved|nutraceutical

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RelatedDiseases for SNHG6_NQO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNQO1C0028797Occupational Diseases4CTD_human
TgeneNQO1C0036341Schizophrenia3PSYGENET
TgeneNQO1C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneNQO1C0023895Liver diseases2CTD_human
TgeneNQO1C0027659Neoplasms, Experimental2CTD_human
TgeneNQO1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNQO1C0004096Asthma1CTD_human
TgeneNQO1C0005695Bladder Neoplasm1CTD_human
TgeneNQO1C0008370Cholestasis1CTD_human
TgeneNQO1C0009404Colorectal Neoplasms1CTD_human
TgeneNQO1C0011616Contact Dermatitis1CTD_human
TgeneNQO1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneNQO1C0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneNQO1C0019080Hemorrhage1CTD_human
TgeneNQO1C0020456Hyperglycemia1CTD_human
TgeneNQO1C0022658Kidney Diseases1CTD_human
TgeneNQO1C0023470Myeloid Leukemia1CTD_human
TgeneNQO1C0026764Multiple Myeloma1CTD_human
TgeneNQO1C0028754Obesity1CTD_human
TgeneNQO1C0030354Papilloma1CTD_human
TgeneNQO1C0030567Parkinson Disease1CTD_human
TgeneNQO1C0033578Prostatic Neoplasms1CTD_human
TgeneNQO1C0235032Neurotoxicity Syndromes1CTD_human
TgeneNQO1C0236663Alcohol withdrawal syndrome1PSYGENET
TgeneNQO1C0525045Mood Disorders1PSYGENET
TgeneNQO1C0853193Bipolar I disorder1PSYGENET
TgeneNQO1C1458155Mammary Neoplasms1CTD_human
TgeneNQO1C1846707SPINOCEREBELLAR ATAXIA 171CTD_human
TgeneNQO1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneNQO1C2609414Acute kidney injury1CTD_human