|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35144 |
FusionGeneSummary for SNHG5_HEY1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNHG5_HEY1 | Fusion gene ID: 35144 | Hgene | Tgene | Gene symbol | SNHG5 | HEY1 | Gene ID | 387066 | 23462 |
| Gene name | small nucleolar RNA host gene 5 | hes related family bHLH transcription factor with YRPW motif 1 | |
| Synonyms | C6orf160|LINC00044|NCRNA00044|U50HG | BHLHb31|CHF2|HERP2|HESR1|HRT-1|OAF1|hHRT1 | |
| Cytomap | 6q14.3 | 8q21.13 | |
| Type of gene | ncRNA | protein-coding | |
| Description | U50 hostlong intergenic non-protein coding RNA 44small nucleolar RNA host gene 5 (non-protein coding) | hairy/enhancer-of-split related with YRPW motif protein 1HES-related repressor protein 1HES-related repressor protein 2basic helix-loop-helix protein OAF1cardiovascular helix-loop-helix factor 2class B basic helix-loop-helix protein 31hairy and enha | |
| Modification date | 20180422 | 20180523 | |
| UniProtAcc | Q9Y5J3 | ||
| Ensembl transtripts involved in fusion gene | ENST00000384338, ENST00000364995, | ENST00000354724, ENST00000337919, ENST00000435063, ENST00000523976, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SNHG5 [Title/Abstract] AND HEY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HEY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16043483|21290414 |
| Tgene | HEY1 | GO:0007219 | Notch signaling pathway | 10964718|25985737 |
| Tgene | HEY1 | GO:0045746 | negative regulation of Notch signaling pathway | 18239137 |
| Tgene | HEY1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15485867 |
| Tgene | HEY1 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 18239137 |
| Tgene | HEY1 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | 18239137 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA946891 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000384338 | ENST00000354724 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-5UTR | ENST00000384338 | ENST00000337919 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-intron | ENST00000384338 | ENST00000435063 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-intron | ENST00000384338 | ENST00000523976 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-5UTR | ENST00000364995 | ENST00000354724 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-5UTR | ENST00000364995 | ENST00000337919 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-intron | ENST00000364995 | ENST00000435063 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-intron | ENST00000364995 | ENST00000523976 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
Top |
FusionProtFeatures for SNHG5_HEY1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNHG5 | HEY1 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Transcriptional repressor which binds preferentially tothe canonical E box sequence 5'-CACGTG-3' (PubMed:11095750).Downstream effector of Notch signaling required for cardiovasculardevelopment. Specifically required for the Notch-inducedendocardial epithelial to mesenchymal transition, which is itselfcriticial for cardiac valve and septum development. May berequired in conjunction with HEY2 to specify arterial cell fate oridentity. Promotes maintenance of neuronal precursor cells andglial versus neuronal fate specification. Represses transcriptionby the cardiac transcriptional activators GATA4 and GATA6 and bythe neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancercells self-renewal (PubMed:25985737).{ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750,ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SNHG5_HEY1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SNHG5_HEY1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SNHG5_HEY1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SNHG5_HEY1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HEY1 | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | HEY1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | HEY1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | HEY1 | C0028945 | oligodendroglioma | 1 | CTD_human |
| Tgene | HEY1 | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
| Tgene | HEY1 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Tgene | HEY1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | HEY1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|