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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35132

FusionGeneSummary for SNHG3_DROSHA

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG3_DROSHA
Fusion gene ID: 35132
HgeneTgene
Gene symbol

SNHG3

DROSHA

Gene ID

8420

29102

Gene namesmall nucleolar RNA host gene 3drosha ribonuclease III
SynonymsNCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-ABETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN
Cytomap

1p35.3

5p13.3

Type of genencRNAprotein-coding
DescriptionU17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding)ribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclear
Modification date2018051920180523
UniProtAcc

Q9NRR4

Ensembl transtripts involved in fusion geneENST00000364938, ENST00000511367, 
ENST00000442743, ENST00000344624, 
ENST00000513349, ENST00000504361, 
Fusion gene scores* DoF score15 X 7 X 4=4203 X 3 X 3=27
# samples 153
** MAII scorelog2(15/420*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNHG3 [Title/Abstract] AND DROSHA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDROSHA

GO:0031053

primary miRNA processing

14508493|15574589

TgeneDROSHA

GO:0050829

defense response to Gram-negative bacterium

20180804

TgeneDROSHA

GO:0050830

defense response to Gram-positive bacterium

20180804


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA644608SNHG3chr1

28834672

+DROSHAchr5

31486670

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000364938ENST00000511367SNHG3chr1

28834672

+DROSHAchr5

31486670

-
intron-3CDSENST00000364938ENST00000442743SNHG3chr1

28834672

+DROSHAchr5

31486670

-
intron-3CDSENST00000364938ENST00000344624SNHG3chr1

28834672

+DROSHAchr5

31486670

-
intron-3CDSENST00000364938ENST00000513349SNHG3chr1

28834672

+DROSHAchr5

31486670

-
intron-intronENST00000364938ENST00000504361SNHG3chr1

28834672

+DROSHAchr5

31486670

-

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FusionProtFeatures for SNHG3_DROSHA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNHG3

DROSHA

Q9NRR4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Ribonuclease III double-stranded (ds) RNA-specificendoribonuclease that is involved in the initial step of microRNA(miRNA) biogenesis. Component of the microprocessor complex thatis required to process primary miRNA transcripts (pri-miRNAs) torelease precursor miRNA (pre-miRNA) in the nucleus. Within themicroprocessor complex, DROSHA cleaves the 3' and 5' strands of astem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that aresubsequently cut by the cytoplasmic DICER to generate maturemiRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in theformation of GW bodies. {ECO:0000269|PubMed:10948199,ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877,ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589,ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099,ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994,ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNHG3_DROSHA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNHG3_DROSHA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNHG3UTP23, TRIM25DROSHABCL6, DGCR8, PSMA1, CUL3, ZNF512B, SRPK2, SRPK1, WWOX, CARM1, HNRNPAB, HNRNPUL2, KHDRBS1, KLHL12, LGALS3BP, MEN1, PDCD6, PKP2, PPFIA1, RBM14, SKIV2L2, U2SURP, THRAP3, YLPM1, ZCCHC8, DDX5, NXF1, BMI1, CHRNA9, EVPL, PPL, SMC2, XPO1, LNPEP, NCK1, RPA1, ZNFX1, SGOL1, NR2E1, KHSRP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNHG3_DROSHA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNHG3_DROSHA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDROSHAC0021364Male infertility1CTD_human
TgeneDROSHAC0036341Schizophrenia1PSYGENET