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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35103

FusionGeneSummary for SNHG14_FUNDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG14_FUNDC1
Fusion gene ID: 35103
HgeneTgene
Gene symbol

SNHG14

FUNDC1

Gene ID

104472715

139341

Gene namesmall nucleolar RNA host gene 14FUN14 domain containing 1
Synonyms115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3AATS-
Cytomap

15q11.2

Xp11.3

Type of genencRNAprotein-coding
DescriptionUBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)FUN14 domain-containing protein 1
Modification date2018032920180523
UniProtAcc

Q8IVP5

Ensembl transtripts involved in fusion geneENST00000549804, ENST00000547292, 
ENST00000424208, ENST00000452731, 
ENST00000554726, ENST00000551631, 
ENST00000459433, ENST00000551361, 
ENST00000553134, ENST00000551938, 
ENST00000384733, ENST00000551077, 
ENST00000546682, ENST00000553108, 
ENST00000384430, ENST00000516123, 
ENST00000553149, ENST00000441592, 
ENST00000365306, ENST00000414175, 
ENST00000456576, ENST00000363358, 
ENST00000424333, ENST00000450809, 
ENST00000453082, ENST00000365067, 
ENST00000390982, ENST00000580438, 
ENST00000378045, ENST00000483115, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SNHG14 [Title/Abstract] AND FUNDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUNDC1

GO:0000422

autophagy of mitochondrion

22267086

TgeneFUNDC1

GO:0001666

response to hypoxia

22267086


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-TP-A8TT-01ASNHG14chr15

25512191

+FUNDC1chrX

44386611

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000549804ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000549804ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000547292ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000547292ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000424208ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000424208ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
3UTR-3CDSENST00000452731ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
3UTR-5UTRENST00000452731ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000554726ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000554726ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551631ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551631ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000459433ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000459433ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551361ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551361ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553134ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553134ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551938ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551938ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000384733ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000384733ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551077ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551077ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000546682ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000546682ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553108ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553108ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000384430ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000384430ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000516123ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000516123ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553149ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553149ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000441592ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000441592ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000365306ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000365306ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000414175ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000414175ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000456576ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000456576ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000363358ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000363358ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000424333ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000424333ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000450809ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000450809ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000453082ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000453082ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000365067ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000365067ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000390982ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000390982ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000580438ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000580438ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-

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FusionProtFeatures for SNHG14_FUNDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNHG14

FUNDC1

Q8IVP5

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Acts as an activator of hypoxia-induced mitophagy, animportant mechanism for mitochondrial quality control.{ECO:0000269|PubMed:22267086}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNHG14_FUNDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNHG14_FUNDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNHG14FUNDC1CTBP1, CTBP2, EHHADH, SNX1, TUFM, YES1, GABARAPL2, GABARAPL1, MTERF3, SH3GLB1, SENP2, MAP1LC3B, MAP1LC3A, SLC25A46, FUNDC2, MARCH5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNHG14_FUNDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNHG14_FUNDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource