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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35101

FusionGeneSummary for SNHG12_SRRT

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG12_SRRT
Fusion gene ID: 35101
HgeneTgene
Gene symbol

SNHG12

SRRT

Gene ID

85028

51593

Gene namesmall nucleolar RNA host gene 12serrate, RNA effector molecule
SynonymsASLNC04080|C1orf79|LINC00100|NCRNA00100|PNAS-123ARS2|ASR2|serrate
Cytomap

1p35.3

7q22.1

Type of genencRNAprotein-coding
Descriptionlong intergenic non-protein coding RNA 100small nucleolar RNA host gene 12 (non-protein coding)serrate RNA effector molecule homologarsenate resistance protein 2arsenate resistance protein ARS2arsenite resistance proteinarsenite-resistance protein 2
Modification date2018052020180519
UniProtAcc

Q9BXP5

Ensembl transtripts involved in fusion geneENST00000475441, ENST00000531126, 
ENST00000488745, ENST00000483436, 
ENST00000384581, ENST00000384584, 
ENST00000384342, 		ENST00000457580, 
ENST00000388793, ENST00000432932, 
ENST00000347433, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 5 X 2=50
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: SNHG12 [Title/Abstract] AND SRRT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1R73443SNHG12chr1

28908310

-SRRTchr7

100485690

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000475441ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000475441ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000475441ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000475441ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000531126ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000531126ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000531126ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000531126ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000488745ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000488745ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000488745ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000488745ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000483436ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000483436ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000483436ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000483436ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384581ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384581ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384581ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384581ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384584ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384584ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384584ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384584ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384342ENST00000457580SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384342ENST00000388793SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384342ENST00000432932SNHG12chr1

28908310

-SRRTchr7

100485690

+
intron-3CDSENST00000384342ENST00000347433SNHG12chr1

28908310

-SRRTchr7

100485690

+

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FusionProtFeatures for SNHG12_SRRT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNHG12

SRRT

Q9BXP5

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNHG12_SRRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNHG12_SRRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNHG12_SRRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNHG12_SRRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSRRTC0005586Bipolar Disorder1PSYGENET
TgeneSRRTC0041696Unipolar Depression1PSYGENET
TgeneSRRTC1269683Major Depressive Disorder1PSYGENET