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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35077

FusionGeneSummary for SNCAIP_KIF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: SNCAIP_KIF3A
Fusion gene ID: 35077
HgeneTgene
Gene symbol

SNCAIP

KIF3A

Gene ID

9627

11127

Gene namesynuclein alpha interacting proteinkinesin family member 3A
SynonymsSYPH1|Sph1FLA10|KLP-20
Cytomap

5q23.2

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionsynphilin-1kinesin-like protein KIF3Akinesin family protein 3Amicrotubule plus end-directed kinesin motor 3A
Modification date2018051920180527
UniProtAcc

Q9Y6H5

Q9Y496

Ensembl transtripts involved in fusion geneENST00000542191, ENST00000261368, 
ENST00000379538, ENST00000379533, 
ENST00000379536, ENST00000261367, 
ENST00000414317, ENST00000503116, 
ENST00000504884, 		ENST00000378746, 
ENST00000378735, ENST00000403231, 
ENST00000487055, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 3 X 5=105
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNCAIP [Title/Abstract] AND KIF3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNCAIP

GO:0008219

cell death

16595633

HgeneSNCAIP

GO:0042417

dopamine metabolic process

14506261

HgeneSNCAIP

GO:0046928

regulation of neurotransmitter secretion

14506261

HgeneSNCAIP

GO:0090083

regulation of inclusion body assembly

15603737


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8DU-01ASNCAIPchr5

121647979

+KIF3Achr5

132070170

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000542191ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000542191ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000542191ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-intronENST00000542191ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261368ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261368ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261368ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000261368ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379538ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379538ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379538ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000379538ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379533ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379533ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379533ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000379533ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379536ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379536ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000379536ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000379536ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261367ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261367ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000261367ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000261367ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000414317ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000414317ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-3CDSENST00000414317ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
5UTR-intronENST00000414317ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000503116ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000503116ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000503116ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-intronENST00000503116ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000504884ENST00000378746SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000504884ENST00000378735SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-3CDSENST00000504884ENST00000403231SNCAIPchr5

121647979

+KIF3Achr5

132070170

-
intron-intronENST00000504884ENST00000487055SNCAIPchr5

121647979

+KIF3Achr5

132070170

-

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FusionProtFeatures for SNCAIP_KIF3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNCAIP

Q9Y6H5

KIF3A

Q9Y496

Microtubule-based anterograde translocator formembranous organelles. Plus end-directed microtubule slidingactivity in vitro. Plays a role in primary cilia formation. Playsa role in centriole cohesion and subdistal appendage organizationand function. Regulates the formation of the subdistal appendagevia recruitement of DCTN1 to the centriole. Also required forciliary basal feet formation and microtubule anchoring to mothercentriole. {ECO:0000250|UniProtKB:P28741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNCAIP_KIF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNCAIP_KIF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNCAIPSNCA, GET4, SH2D3C, PTN, PARK2, SNCAIP, GSK3B, SIAH2, SIAH1, RNF19A, HERPUD1, NUDT21, C11orf58, PPP1CA, PSMC4, YWHAH, ARIH1, NUB1, PINK1, PPHLN1, CSNK2A1, PIN1, PPP1CC, KALRNKIF3AMAP3K10, MAP3K11, USP7, GRB2, PLEKHA5, DISC1, ARRB1, RANBP2, VHL, KIF3B, KIFAP3, NEK1, APP, LIG4, NOTCH1, CFTR, CASP1, OBFC1, DTNBP1, FASN, NTRK1, MED4, SCLT1, RAN, DHX34, GAK, KIF3C, RPA1, NUF2, CTNNBL1, FAM192A, SSH2, KIAA1279, H3F3B, TYW3, LYPLA2, HEPHL1, ATG9B, VSIG8, PKP3, DUSP14, EXOC3, PADI3, MFHAS1, HENMT1, SELENBP1, SSX2, LYG2, MAP1LC3B2, TRIM29, ZNF785, FAM26D, PLCD1, ALOX15B, APTX, RGS20, ACPP, TNFRSF8, ANXA8, ARL8A, PI4K2A, LRRC15, PREP, DSG4, SERPINB5, PKP1, HSDL2, DNPEP, XRCC4, DNAJC9, SSNA1, SLC9A3R2, CEP170, INTU


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNCAIP_KIF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNCAIP_KIF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF3AC0004096Asthma1CTD_human
TgeneKIF3AC0005941Bone Diseases, Developmental1CTD_human
TgeneKIF3AC0152427Polydactyly1CTD_human
TgeneKIF3AC0376634Craniofacial Abnormalities1CTD_human