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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35076

FusionGeneSummary for SNCAIP_DNAJC10

check button Fusion gene summary
Fusion gene informationFusion gene name: SNCAIP_DNAJC10
Fusion gene ID: 35076
HgeneTgene
Gene symbol

SNCAIP

DNAJC10

Gene ID

9627

54431

Gene namesynuclein alpha interacting proteinDnaJ heat shock protein family (Hsp40) member C10
SynonymsSYPH1|Sph1ERdj5|JPDI|MTHr|PDIA19
Cytomap

5q23.2

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionsynphilin-1dnaJ homolog subfamily C member 10DnaJ (Hsp40) homolog, subfamily C, member 10ER-resident protein ERdj5J-domain-containing protein disulfide isomerase-like proteinendoplasmic reticulum DNA J domain-containing protein 5macrothioredoxinprotein disulfi
Modification date2018051920180519
UniProtAcc

Q9Y6H5

Q8IXB1

Ensembl transtripts involved in fusion geneENST00000542191, ENST00000261368, 
ENST00000379538, ENST00000379533, 
ENST00000379536, ENST00000261367, 
ENST00000414317, ENST00000503116, 
ENST00000504884, 		ENST00000264065, 
ENST00000469118, ENST00000537515, 
Fusion gene scores* DoF score5 X 4 X 4=801 X 1 X 1=1
# samples 51
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SNCAIP [Title/Abstract] AND DNAJC10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNCAIP

GO:0008219

cell death

16595633

HgeneSNCAIP

GO:0042417

dopamine metabolic process

14506261

HgeneSNCAIP

GO:0046928

regulation of neurotransmitter secretion

14506261

HgeneSNCAIP

GO:0090083

regulation of inclusion body assembly

15603737

TgeneDNAJC10

GO:0001933

negative regulation of protein phosphorylation

19122239

TgeneDNAJC10

GO:0034975

protein folding in endoplasmic reticulum

23769672

TgeneDNAJC10

GO:0034976

response to endoplasmic reticulum stress

19122239

TgeneDNAJC10

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

19122239


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB219427SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000542191ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000542191ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000542191ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000261368ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000261368ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000261368ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000379538ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379538ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379538ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000379533ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379533ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379533ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000379536ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379536ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000379536ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000261367ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000261367ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000261367ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000414317ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000414317ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000414317ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000503116ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000503116ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000503116ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3CDSENST00000504884ENST00000264065SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000504884ENST00000469118SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+
intron-3UTRENST00000504884ENST00000537515SNCAIPchr5

121654894

-DNAJC10chr2

183584821

+

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FusionProtFeatures for SNCAIP_DNAJC10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNCAIP

Q9Y6H5

DNAJC10

Q8IXB1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNCAIP_DNAJC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNCAIP_DNAJC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNCAIP_DNAJC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNCAIP_DNAJC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDNAJC10C0033578Prostatic Neoplasms1CTD_human