FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35047

FusionGeneSummary for SNAP23_BAZ2A

check button Fusion gene summary
Fusion gene informationFusion gene name: SNAP23_BAZ2A
Fusion gene ID: 35047
HgeneTgene
Gene symbol

SNAP23

BAZ2A

Gene ID

8773

11176

Gene namesynaptosome associated protein 23bromodomain adjacent to zinc finger domain 2A
SynonymsHsT17016|SNAP-23|SNAP23A|SNAP23BTIP5|WALp3
Cytomap

15q15.1-q15.2

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptosomal-associated protein 23synaptosomal-associated protein, 23kDsynaptosomal-associated protein, 23kDasynaptosome associated protein 23kDavesicle-membrane fusion protein SNAP-23bromodomain adjacent to zinc finger domain protein 2ATTF-I interacting peptide 5TTF-I-interacting protein 5transcription termination factor I-interacting protein 5
Modification date2018052720180519
UniProtAcc

O00161

Q9UIF9

Ensembl transtripts involved in fusion geneENST00000249647, ENST00000566141, 
ENST00000564153, ENST00000349777, 
ENST00000567094, ENST00000397138, 
ENST00000379441, ENST00000179765, 
ENST00000551812, ENST00000549884, 
ENST00000553222, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 7 X 2=98
# samples 58
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNAP23 [Title/Abstract] AND BAZ2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA830385SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
ChiTaRS3.1AW978559SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000249647ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000249647ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000249647ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000249647ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000249647ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000566141ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000566141ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000566141ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000566141ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000566141ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000564153ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000564153ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000564153ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000564153ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000564153ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000349777ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000349777ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000349777ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000349777ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
3UTR-intronENST00000349777ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000567094ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000567094ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000567094ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000567094ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000567094ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000397138ENST00000379441SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000397138ENST00000179765SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000397138ENST00000551812SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000397138ENST00000549884SNAP23chr15

42824565

-BAZ2Achr12

57003085

+
intron-intronENST00000397138ENST00000553222SNAP23chr15

42824565

-BAZ2Achr12

57003085

+

Top

FusionProtFeatures for SNAP23_BAZ2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNAP23

O00161

BAZ2A

Q9UIF9

Essential component of the high affinity receptor forthe general membrane fusion machinery and an important regulatorof transport vesicle docking and fusion. Essential component of the NoRC (nucleolar remodelingcomplex) complex, a complex that mediates silencing of a fractionof rDNA by recruiting histone-modifying enzymes and DNAmethyltransferases, leading to heterochromatin formation andtranscriptional silencing. In the complex, it plays a central roleby being recruited to rDNA and by targeting chromatin modifyingenzymes such as HDAC1, leading to repress RNA polymerase Itranscription. Recruited to rDNA via its interaction with TTF1 andits ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12acbut not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAsthat are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNAsilencing (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SNAP23_BAZ2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SNAP23_BAZ2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SNAP23_BAZ2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SNAP23_BAZ2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSNAP23C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSNAP23C0151744Myocardial Ischemia1CTD_human
TgeneBAZ2AC0033578Prostatic Neoplasms1CTD_human