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Fusion gene ID: 34974 |
FusionGeneSummary for SMS_DYRK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMS_DYRK2 | Fusion gene ID: 34974 | Hgene | Tgene | Gene symbol | SMS | DYRK2 | Gene ID | 10743 | 8445 |
| Gene name | retinoic acid induced 1 | dual specificity tyrosine phosphorylation regulated kinase 2 | |
| Synonyms | SMCR|SMS | - | |
| Cytomap | 17p11.2 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid-induced protein 1Smith-Magenis syndrome chromosome region | dual specificity tyrosine-phosphorylation-regulated kinase 2dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P52788 | Q92630 | |
| Ensembl transtripts involved in fusion gene | ENST00000415881, ENST00000404933, ENST00000379404, ENST00000478094, | ENST00000344096, ENST00000393555, ENST00000537632, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 7 X 4 X 6=168 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMS [Title/Abstract] AND DYRK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMS | GO:0045893 | positive regulation of transcription, DNA-templated | 22578325 |
| Tgene | DYRK2 | GO:0006468 | protein phosphorylation | 11311121 |
| Tgene | DYRK2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 17349958 |
| Tgene | DYRK2 | GO:0045725 | positive regulation of glycogen biosynthetic process | 11311121 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A14T-01A | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000415881 | ENST00000344096 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5UTR-intron | ENST00000415881 | ENST00000393555 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5UTR-3UTR | ENST00000415881 | ENST00000537632 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| In-frame | ENST00000404933 | ENST00000344096 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5CDS-intron | ENST00000404933 | ENST00000393555 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5CDS-3UTR | ENST00000404933 | ENST00000537632 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| In-frame | ENST00000379404 | ENST00000344096 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5CDS-intron | ENST00000379404 | ENST00000393555 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 5CDS-3UTR | ENST00000379404 | ENST00000537632 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 3UTR-3CDS | ENST00000478094 | ENST00000344096 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 3UTR-intron | ENST00000478094 | ENST00000393555 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
| 3UTR-3UTR | ENST00000478094 | ENST00000537632 | SMS | chrX | 21958991 | + | DYRK2 | chr12 | 68043577 | + |
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FusionProtFeatures for SMS_DYRK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMS | DYRK2 |
| Catalyzes the production of spermine from spermidine anddecarboxylated S-adenosylmethionine (dcSAM). | Serine/threonine-protein kinase involved in theregulation of the mitotic cell cycle, cell proliferation,apoptosis, organization of the cytoskeleton and neurite outgrowth.Functions in part via its role in ubiquitin-dependent proteasomalprotein degradation. Functions downstream of ATM andphosphorylates p53/TP53 at 'Ser-46', and thereby contributes tothe induction of apoptosis in response to DNA damage.Phosphorylates NFATC1, and thereby inhibits its accumulation inthe nucleus and its transcription factor activity. PhosphorylatesEIF2B5 at 'Ser-544', enabling its subsequent phosphorylation andinhibition by GSK3B. Likewise, phosphorylation of NFATC1,CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequentphosphorylation by GSK3B. May play a general role in the primingof GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thusregulating glycogen synthesis. Mediates EDVP E3 ligase complexformation and is required for the phosphorylation and subsequentdegradation of KATNA1. Phosphorylates TERT at 'Ser-457', promotingTERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, andthereby increases its ubiquitin ligase activity. Promotes theproteasomal degradation of MYC and JUN, and thereby regulatesprogress through the mitotic cell cycle and cell proliferation.Promotes proteasomal degradation of GLI2 and GLI3, and therebyplays a role in smoothened and sonic hedgehog signaling. Plays arole in cytoskeleton organization and neurite outgrowth via itsphosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2,CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2,MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylatehistone H1, histone H3 and histone H2B (in vitro). Canphosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121,ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110,ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445,ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958,ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021,ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329,ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280,ECO:0000269|PubMed:9748265}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMS_DYRK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMS_ENST00000404933_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_602aa MAAARHSTLDFMLGAKGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQV QQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP >In-frame_SMS_ENST00000379404_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_602aa MAAARHSTLDFMLGAKGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQV QQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMS_ENST00000404933_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_1806nt ATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCGTTCGTCAGCTTCAGGCTTCC CCGGGGCTCGGTGCAGGGGCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGCCTCTCCGGGCCAGCAACGCT GCCGCCGCAGCCCACACGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTT CAACAGTTGTTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAGTGGGCAAAACGGGCTTGCCA GTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAA GCCACCCCCATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAA ATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATAT GTGCAGGTGCCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTGGGCAGGTGGTCAAGGCCTAC GATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTG GAACACCTGCGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACATCTGCATGACG TTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCAC TCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGT AGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCT CCAGAAGTGATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAGAGCTCCTGACGGGTTACCCC CTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAA CGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGC CGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGAC TTCTTAAAACAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCTGGCTGAGGAGGCGGTTGCCA AAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCT AGCTCAGCTTCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGCCAAAACTTGTT >In-frame_SMS_ENST00000379404_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_1806nt ATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCGTTCGTCAGCTTCAGGCTTCC CCGGGGCTCGGTGCAGGGGCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGCCTCTCCGGGCCAGCAACGCT GCCGCCGCAGCCCACACGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTT CAACAGTTGTTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAGTGGGCAAAACGGGCTTGCCA GTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAA GCCACCCCCATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAA ATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATAT GTGCAGGTGCCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTGGGCAGGTGGTCAAGGCCTAC GATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTG GAACACCTGCGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACATCTGCATGACG TTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCAC TCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGT AGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCT CCAGAAGTGATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAGAGCTCCTGACGGGTTACCCC CTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAA CGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGC CGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGAC TTCTTAAAACAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCTGGCTGAGGAGGCGGTTGCCA AAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCT AGCTCAGCTTCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGCCAAAACTTGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMS_ENST00000404933_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_8751nt GTTTCCACCATTAGCGAGGCCTCACACCCGGCGCTCCAAGTTCGGGGCTGGAGGCGTCCCGGCTTCCTCCCTCCCGGAGCGGGACCGGCC CCGCCCCCGCGCCCCGGGTCGCTCCCGGCGGCCCCTCCCACCTCCTAGTCCTGGCCTCCCCGGGCGCAGCACACTCCCAGCCGGCCGCAG CCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCTGCTCCCCCAGGCATGGCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCAC AGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCGTTCGTCAGCTTCAGGCTTCCCCGGGGCTCGGTGCAGGG GCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGCCTCTCCGGGCCAGCAACGCTGCCGCCGCAGCCCACACG ATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGAT AACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAGTGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAG CTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAAGCCACCCCCATGACACCT GAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTA AATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATATGTGCAGGTGCCCCACGAT CACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTGGGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAG CACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAG GACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATG AACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCACTCGATTCTGCAGTGCTTG GATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTA ATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGG GCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAGAGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGAT GAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAACGAGCCAAAAATTTTGTG AGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAA CTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGACTTCTTAAAACAGTGTTTA GAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCTGGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAG AAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTG AGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGCCAAAACTTGTTAGCTGAGCTCACGTCCCC TGATGCTGGTAACCTGAAAGATACGACATTGCTGAGCCTTACTGGGTTGAAAAGGAGTAGCTCAGACCTGTTTTTATTTGCTCAATAACT CTACTCATTTGTATCTTTTCAGCACTTAATTTTAATGTAAGAAAGTTGTTCATTTTGTTTTTATAAAATACATGAGGACAATGCTTTAAG TTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAATGAGCCTTACTGTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGC CACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATTCACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGG GTGACAGCCCCTTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCACAGGTGTAGCATGTCCTGCTTCCGTTTTTCATAAATTAA TCTGGGTGTTGGGGGTAGTGGGAGGAGAACGGTCAGAATCAAAGTGACATTCTAAGAAAAACTGTACCTTAGAGATTTTCCTCTAGTGCT CAAACAAATACAAAATAAGATCCCCAAGGTTTAAACTGCCCAGTTAGCATTCTGACATTCTAAAAGCCGGCAAAGCAGCTTTTAGTGGAT AAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAGTATGATCGGTGAGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCT TTTGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTCTGCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGT CTGTTGCTTGCATTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTGTTAATACAGAAAAGAGACATTTCAGCTGTGATTATGAC CATTGTTTCATATTCCAATTAAAAAAAGAACAGCAGCCTAGCTACTTAAGGTGGGGATTTCCATAGTTCCAAAGAAGATTTAGCAGATTA GAGTGAGTTCACACTTTTCAGGTGCCACTGTAAGGTTCTCTCAGCCTGGGAAACTATCAACTCTTTCTTTAAAAAGAAAGAGGGTTGAAA ATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGGCCAATGTTAACAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTA AATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTCCTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATT GTTTTTGTGGGAATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAAAGAATATTTTCTTCTCTGAATAATAATTATTTTCACAG TGAAAATTTCAGTATTTTATCACTAATGTATGAGCAATGATCTATATCAATTTCAAGGCACGTGAAAAAAATTTTTTAGTATGTGCAATT TAATATAGAAAGATTTCTGCCTGTTTGGACAATAGGTTTTGGGTAGTACAGATTAGGATAAGTAAGCTTATATATGCACAGAGATTATTG TATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGTCCCCAGTGAGGCCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCC TACAGTTTATCTTAAGAAAAAAAAAAAGGTTTGAAAAAAACACTTTAATTTAGGCTTCGTTGGTTGATGGTGGAAAAAAATGCTCAGGAA ATATTTCAGATATTTGCCAAAAAACCAGTAATAAGGTTACCTTATTAAAATAGTGATATTTGCTTTACTATTTAAGGTGTCACTGATAAA TTAATTTGTACTTCTGTGTTTAGAAATTATAGCTTCTTTTCCCTTAGTCAAATTTTTTAGCATATTATACACATTTCTGTGTAATCTGTG GAAGTGCAATAATATGTTAGTAAGTTACATTTTAAATAATGCTCATGTGACAATACTCCCAATCAATGGCTTATAGAATTTAAAGATCTG TATATTAGATTTTGGCTTAAAGGCATGAGAAGTATAAGACTTGGTTTGGTGGCTTTGTAAGACCACCAGCCTCTTAATGATGGTTAGCTT CTTTAGGTCATTAAATCAATAAAAACATATAATGCTGTTTTGCTCTTCTAATGCTCCTCTTCCATTTCCAGTTATCTTCACATTTACATT TAAATATACAAACCTGAGCCTGCCATTATTAATTTCCCTATAAAATGACGATACATGTGAACATTTATAAATGGACTAATACTGCTTGTC TTTCCCCCACCGCACAAAACTGGTTCTTAAGATGCCAGCAATGAATTTGAGACTATCTTTATTTATAAATGGAAACCGGAAACTTTTATA CCAAACTATAATAATGTGCAGCACTGTAGGGCTTTTTTTTTTTTCCCTCCAAATACAGTGAAATTTTTTTATTCACAAGAGCTGCCACAT CTCAGCATTTAGTAATAGAGCTGCTTTAATAAAATTCTAGTTTGATTGTCATGTCAAAAAAAGAAAAATGTTGCATCTTTGTGATTTTAA AACATAAATTAATGAAGGCTCTGATAGGCTATTAGGAGTTGGCTTGGAAACAGTTTTTGGTCTCACAGGTTACCATTGTTTGGGGATGTC TGAGCTGTTTTCAGATCTAGGAATAGCACAGTGTTGTCTTGTCTTTGGCAGTCTCATTTGGCTCTGTTTCTTGCACCACCAGCGTGTTCA TTACCACTTAAATATATTGCTACAGCAGTGGAACAACAGAGTGGTGCAAGACACTGTAGATTAACGGTAGAGGAGAAATTGTGCCCTTAG TGTTAACAATGTGCCTTTTGTTCTGAATGCCATGTTGTAGGGCATGCATTTTTTGGCCTCTTTAACTCTTCGAATTCTAGTCAGTAAGAA TGGAACCCATCTCTGCAAAGATACATCTGTCTTAAATATCTAGTTACAGGCCTTAATAGAAACCATAAGGCATGACTCATCTTCAGGCAC TGAAAAAAGATAACCATCAGGTAGTGTTACACAAGGACTTCCTATATTTAAGGGGTTAAAGATGGTCTTTGTTGTATCTTAACATCAGAC TGATTTTTACATTTTTTTTTTGTTATGCTAACACTAGACAAAAATCAACTGTATTTGTAAAAATTTACCTCAAACCATTTAATTTTATAG TGTGATTAATCCCAGGGCATTTGGTATGAACCAAAGTGCATTCCTTTTATATGTGCCTGGCTCTAGTAAGGATGGCCAGGGATTTTTACA ATTTGGGTGCAAGGCACTTAAGCCACTTTTAAACTTAATGGGTGGTTTGGGGTCGTGTTAAATGACTCCATCAGAATGTTAGAAAACACT TTAGGCATCAGTAGCATTGGGCCATATTGGAATCCTAAAGTGTGAATTATTTTAAGGAGAGCATTCATTTTTGTAATTTTTTTCATCAAA AATATTTCTGGTAAGCAGAAGACTTTTTAAAAAAACTGATCTGGTCTCGGTAAAGGTTTTAATATTGCCCAACATAATGCTGTAATAGCA TTAAAAAAAGTATTTGTGAACTCTGTTTCTTAGGGGCTTGTACATCTCTCTGCTATGGACATACATAAAATTAATTGTAATTATACTCAG CTCAACTGCTACAGTTCTGTCTAGGCAGTGGCTTGGGTTTTTATCGAGCAACAACTTAGACACGTGACTGTAATATGCTGCAACTGTGTG TACTGAAAATATGTGAAAATGGTTGAATGTGGACTGTGTATATATGTATGTAAAAATTTCTGTGAGATGCTGCTGTCGCCACTTAACATT AAATATGTTCTAGTGGATTTTAATCCTAGTGGCCAGTTCTATGATACTGTATGTATTATACAGCTGATGACAGGAGTAAGACTGTTTAGT GAATATCTGTTAAATTTTATTGTTGTGGCCAGAGATAATTTCAGAATAAAATTTTAATGTCCTACCTTACTTCTCTCCCCTTTCTAACTA TAATTTAACTCCTGATCTATTTCTGGTATTATCCTTTGTCAATTAGCCTGGAGAGGGTTTAGAATGCAAAATGGATAGCTCTATATCAGG GTCTTGAGAAGTTAAAATAATTCATTCTACTAGTTTGTTCATAGCAATACTTTATTAGTTCAATATAAGTATGCAGATTCCAAGTGGAAA AACAAAGGTTTTAGTAAGTAGTTCTTGCTTTTCCCAGGATATTCTATTCCTTCACCTGTCAGATTTTTATGTTAACTTTTTTATATATAG CCTCTGCTGTGTTCTTTATTATGCTAGAGCTTCATATCTTCTTTTATTTTAACCTTCACAATGATAGTTAAGCTGGGGGAGCAGAACCTG TCAATTATTCCCCACCAGTCTTCATTCTTTTCTCTGCACAAGTTCTGGTAAATTATTCTAATGTGCTCTAACCAGTTCCACCCAATGTTT TTTAATGCTTATGAGTTTGCAGTTTTTGTACTTGGTGGTCTCTGTGGTTCACATTTTTTTGTGTTGTAGTGTCTCCTGCCTCGGTTGGCT CAGAAAATAAGGCCTAGGAACTGCAATTAGCTCATGATTTGTCAAGTTCAGTTAGTACCAAGCTAAGAGTTTACTTACAGATGACAGCAA GCAGATGCTCTAGTAATTCGTCAGACATTGCAGGGATATTGTGTAGTCAGATATTACCCTCTTGTGGAAAGAACTACCTCACATCATTAT TTATTTCCCTTCTGTTACCAACAGCCAAGGAATTACTTAGTGTGGCTCCCTGCATCAATACTGGGATATGCTTAAACAAGGGAATGCCAT AAGAGTTCCCAATTGCCTCGTCATAGCCTGGGCCATAGATTTTTGTTACTGCTAATCTTGCTTCTTAAAGTTCACACCCAGTGCAAAAAA CCCAATCAGCAAACTAACCCCAAAATCCAATATATTTAGAAATGTAAGTGTTAAGAGATGTGCATTATGTACAAAATTGAAAATTGGTGC TAAAGTGGCAATGTCAATTTAAAATTTCTTGTCCAGATCTGACTGACTGACTCAGGAGATTATAGTTCCTACTCATTCTCTTTCCTTTTA TCAGATCTTTCAAAAGCGCTTTTTAAAATTGATCAATGTGCAATTCTGTTTGAGTCTCTACAGTCCTATCCCTTTTGGAATGAACAGCTA CACAAATAAATATTCTTGGAACTTCGAAGTTGTCTTCAAACTAGCTCTAGAAAATGTCCCTAGTTGACATTAGTGTTGGTCTGTTAGAAG GGGAAATTGATTTGACTGCTTCATGTTTTGAAAAGAGCATTAAGAGGGATTTGAGGAAGGTATATGTGGCTTTCTTTTTTTTTCTTAAGT TTGAATTACACTTGATTTCCTTTGGGTTATTAGGCAGATAAACCCTTGTCATTAGTAATACTTAGCACTGTCCAAAATGAAAAATGACTG CCAGTGTGTTGCACATACATAAGAAAATTACATCTTACTGCGAAGTCTTTGGTTTGTTTCCTTATTTGGTTTGACTTTGACTTACTATTT TGCTATGGTCATATCCTTAATATCTGCGGTACATTTCATATATATATATGGGGTGGGAGCATAATTGCCATTCCCATGTGTCTCAAGGAA GCTTAATGAGGAAACTAATGAGTTAATATTAACTCTTCTGAAGAAAGCTGACATTTTAGGAGTATTAAGTCATCTGTCGTTAAGGAGCAG CAAGAATATATTATGATTGTATCACATGTTCCAGAAGAGCATTACCCCTTACATAGAAAGCTCCTTGGAGATTTCATGATGTTGGATGAA CATCAGTTTATCCTTATACATCCCTATGAGCTATAATTATCCTCATTTGATACTTGAGGAAACTGAAGTGACTTGCTCCAAAGTTGACTA CAAAAACATTGCAGTTTGAGGCTTAGGTTGTAATCAGGTAATTTTGGTCTTGGACAGTAAGGGAAAATCCATAATACATAAAACACAAAA GTTTAGAAAGGGGGGGAAGTTGAGCTAGCAATGGGCATTTCTATTATTTAAGTTACATATCAGTTTCCAGGAATATTTTTCAAATGGGAC AAACTAAAAAGTTGAGGACTAGAGCATCGTAGTGTCTAAGTGCACCTAATAACTTAATGCATGTGCACACACCCTCAGTTAATTTGTAAG AGAGTGACTTCTCATTGTTATTTGTGGAGAGGCTAATTATAGTAGCTTCATTCTTTATTTTCTGTGTTCTTAAATTTTTTTTTACATTTG AAAGTATGAAAATACTATTTTTGACACTTTACTGATACTCAGGGATTAAAAGTTAAATTTTACTGACTGTAGCAGCAGGTAAATCTCTTA AATTTACTCAGGTTTCCTATCCTTTGCCTCCATATTTAAGAAAATATAGAATGCCTGCCAGGGAAATATATAAAAATAAAAATTTCAAAT ACAATTTTAAAATACCAATTTGTAAATAAACCAATTTTACAAACTAAAATATTGTGTCTTTCCTTGCTTTTTATCCCAATTTATCTCCCC TCCTAAGTTTGAGGAGTTTTATATATTAAGGCTATTTCTTCATTTGTAAAAATGAAGTATGCTATTTGCAAAGCAAAAGCCCATGAAAAG CCCCAAATCATTTAAGTAAAGCTTACTGAATTGTTTTCAATTGTTTTGGGAGAAATGTAACTAATTATAAGCAATTTATGTGGACCAGCA >In-frame_SMS_ENST00000379404_chrX_21958991_+_DYRK2_ENST00000344096_chr12_68043577_+_8609nt GGCCTCCCCGGGCGCAGCACACTCCCAGCCGGCCGCAGCCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCTGCTCCCCCAGGCATG GCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCG TTCGTCAGCTTCAGGCTTCCCCGGGGCTCGGTGCAGGGGCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGC CTCTCCGGGCCAGCAACGCTGCCGCCGCAGCCCACACGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACG CTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAG TGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGG AAGGCATGGGGAAGGTGAAAGCCACCCCCATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATG AGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATG ATGATGACCAGGGATCATATGTGCAGGTGCCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTG GGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAG CGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCC GCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTT TGGTTCGCAAGTTTGCCCACTCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACA TTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCC AGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAG AGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGA AACTGCTGGATGCATCCAAACGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCT CTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTG ATGATCCCCTTTTCCTTGACTTCTTAAAACAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCT GGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATAT CCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGA CAGTGTTGCCAAAACTTGTTAGCTGAGCTCACGTCCCCTGATGCTGGTAACCTGAAAGATACGACATTGCTGAGCCTTACTGGGTTGAAA AGGAGTAGCTCAGACCTGTTTTTATTTGCTCAATAACTCTACTCATTTGTATCTTTTCAGCACTTAATTTTAATGTAAGAAAGTTGTTCA TTTTGTTTTTATAAAATACATGAGGACAATGCTTTAAGTTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAATGAGCCTTACT GTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGCCACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATT CACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGGGTGACAGCCCCTTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCAC AGGTGTAGCATGTCCTGCTTCCGTTTTTCATAAATTAATCTGGGTGTTGGGGGTAGTGGGAGGAGAACGGTCAGAATCAAAGTGACATTC TAAGAAAAACTGTACCTTAGAGATTTTCCTCTAGTGCTCAAACAAATACAAAATAAGATCCCCAAGGTTTAAACTGCCCAGTTAGCATTC TGACATTCTAAAAGCCGGCAAAGCAGCTTTTAGTGGATAAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAGTATGATCGGTG AGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCTTTTGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTCT GCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGTCTGTTGCTTGCATTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTG TTAATACAGAAAAGAGACATTTCAGCTGTGATTATGACCATTGTTTCATATTCCAATTAAAAAAAGAACAGCAGCCTAGCTACTTAAGGT GGGGATTTCCATAGTTCCAAAGAAGATTTAGCAGATTAGAGTGAGTTCACACTTTTCAGGTGCCACTGTAAGGTTCTCTCAGCCTGGGAA ACTATCAACTCTTTCTTTAAAAAGAAAGAGGGTTGAAAATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGGCCAATGTTAA CAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTAAATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTC CTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATTGTTTTTGTGGGAATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAA AGAATATTTTCTTCTCTGAATAATAATTATTTTCACAGTGAAAATTTCAGTATTTTATCACTAATGTATGAGCAATGATCTATATCAATT TCAAGGCACGTGAAAAAAATTTTTTAGTATGTGCAATTTAATATAGAAAGATTTCTGCCTGTTTGGACAATAGGTTTTGGGTAGTACAGA TTAGGATAAGTAAGCTTATATATGCACAGAGATTATTGTATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGTCCCCAGTGAGG CCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCCTACAGTTTATCTTAAGAAAAAAAAAAAGGTTTGAAAAAAACACTTTAATTTA GGCTTCGTTGGTTGATGGTGGAAAAAAATGCTCAGGAAATATTTCAGATATTTGCCAAAAAACCAGTAATAAGGTTACCTTATTAAAATA GTGATATTTGCTTTACTATTTAAGGTGTCACTGATAAATTAATTTGTACTTCTGTGTTTAGAAATTATAGCTTCTTTTCCCTTAGTCAAA TTTTTTAGCATATTATACACATTTCTGTGTAATCTGTGGAAGTGCAATAATATGTTAGTAAGTTACATTTTAAATAATGCTCATGTGACA ATACTCCCAATCAATGGCTTATAGAATTTAAAGATCTGTATATTAGATTTTGGCTTAAAGGCATGAGAAGTATAAGACTTGGTTTGGTGG CTTTGTAAGACCACCAGCCTCTTAATGATGGTTAGCTTCTTTAGGTCATTAAATCAATAAAAACATATAATGCTGTTTTGCTCTTCTAAT GCTCCTCTTCCATTTCCAGTTATCTTCACATTTACATTTAAATATACAAACCTGAGCCTGCCATTATTAATTTCCCTATAAAATGACGAT ACATGTGAACATTTATAAATGGACTAATACTGCTTGTCTTTCCCCCACCGCACAAAACTGGTTCTTAAGATGCCAGCAATGAATTTGAGA CTATCTTTATTTATAAATGGAAACCGGAAACTTTTATACCAAACTATAATAATGTGCAGCACTGTAGGGCTTTTTTTTTTTTCCCTCCAA ATACAGTGAAATTTTTTTATTCACAAGAGCTGCCACATCTCAGCATTTAGTAATAGAGCTGCTTTAATAAAATTCTAGTTTGATTGTCAT GTCAAAAAAAGAAAAATGTTGCATCTTTGTGATTTTAAAACATAAATTAATGAAGGCTCTGATAGGCTATTAGGAGTTGGCTTGGAAACA GTTTTTGGTCTCACAGGTTACCATTGTTTGGGGATGTCTGAGCTGTTTTCAGATCTAGGAATAGCACAGTGTTGTCTTGTCTTTGGCAGT CTCATTTGGCTCTGTTTCTTGCACCACCAGCGTGTTCATTACCACTTAAATATATTGCTACAGCAGTGGAACAACAGAGTGGTGCAAGAC ACTGTAGATTAACGGTAGAGGAGAAATTGTGCCCTTAGTGTTAACAATGTGCCTTTTGTTCTGAATGCCATGTTGTAGGGCATGCATTTT TTGGCCTCTTTAACTCTTCGAATTCTAGTCAGTAAGAATGGAACCCATCTCTGCAAAGATACATCTGTCTTAAATATCTAGTTACAGGCC TTAATAGAAACCATAAGGCATGACTCATCTTCAGGCACTGAAAAAAGATAACCATCAGGTAGTGTTACACAAGGACTTCCTATATTTAAG GGGTTAAAGATGGTCTTTGTTGTATCTTAACATCAGACTGATTTTTACATTTTTTTTTTGTTATGCTAACACTAGACAAAAATCAACTGT ATTTGTAAAAATTTACCTCAAACCATTTAATTTTATAGTGTGATTAATCCCAGGGCATTTGGTATGAACCAAAGTGCATTCCTTTTATAT GTGCCTGGCTCTAGTAAGGATGGCCAGGGATTTTTACAATTTGGGTGCAAGGCACTTAAGCCACTTTTAAACTTAATGGGTGGTTTGGGG TCGTGTTAAATGACTCCATCAGAATGTTAGAAAACACTTTAGGCATCAGTAGCATTGGGCCATATTGGAATCCTAAAGTGTGAATTATTT TAAGGAGAGCATTCATTTTTGTAATTTTTTTCATCAAAAATATTTCTGGTAAGCAGAAGACTTTTTAAAAAAACTGATCTGGTCTCGGTA AAGGTTTTAATATTGCCCAACATAATGCTGTAATAGCATTAAAAAAAGTATTTGTGAACTCTGTTTCTTAGGGGCTTGTACATCTCTCTG CTATGGACATACATAAAATTAATTGTAATTATACTCAGCTCAACTGCTACAGTTCTGTCTAGGCAGTGGCTTGGGTTTTTATCGAGCAAC AACTTAGACACGTGACTGTAATATGCTGCAACTGTGTGTACTGAAAATATGTGAAAATGGTTGAATGTGGACTGTGTATATATGTATGTA AAAATTTCTGTGAGATGCTGCTGTCGCCACTTAACATTAAATATGTTCTAGTGGATTTTAATCCTAGTGGCCAGTTCTATGATACTGTAT GTATTATACAGCTGATGACAGGAGTAAGACTGTTTAGTGAATATCTGTTAAATTTTATTGTTGTGGCCAGAGATAATTTCAGAATAAAAT TTTAATGTCCTACCTTACTTCTCTCCCCTTTCTAACTATAATTTAACTCCTGATCTATTTCTGGTATTATCCTTTGTCAATTAGCCTGGA GAGGGTTTAGAATGCAAAATGGATAGCTCTATATCAGGGTCTTGAGAAGTTAAAATAATTCATTCTACTAGTTTGTTCATAGCAATACTT TATTAGTTCAATATAAGTATGCAGATTCCAAGTGGAAAAACAAAGGTTTTAGTAAGTAGTTCTTGCTTTTCCCAGGATATTCTATTCCTT CACCTGTCAGATTTTTATGTTAACTTTTTTATATATAGCCTCTGCTGTGTTCTTTATTATGCTAGAGCTTCATATCTTCTTTTATTTTAA CCTTCACAATGATAGTTAAGCTGGGGGAGCAGAACCTGTCAATTATTCCCCACCAGTCTTCATTCTTTTCTCTGCACAAGTTCTGGTAAA TTATTCTAATGTGCTCTAACCAGTTCCACCCAATGTTTTTTAATGCTTATGAGTTTGCAGTTTTTGTACTTGGTGGTCTCTGTGGTTCAC ATTTTTTTGTGTTGTAGTGTCTCCTGCCTCGGTTGGCTCAGAAAATAAGGCCTAGGAACTGCAATTAGCTCATGATTTGTCAAGTTCAGT TAGTACCAAGCTAAGAGTTTACTTACAGATGACAGCAAGCAGATGCTCTAGTAATTCGTCAGACATTGCAGGGATATTGTGTAGTCAGAT ATTACCCTCTTGTGGAAAGAACTACCTCACATCATTATTTATTTCCCTTCTGTTACCAACAGCCAAGGAATTACTTAGTGTGGCTCCCTG CATCAATACTGGGATATGCTTAAACAAGGGAATGCCATAAGAGTTCCCAATTGCCTCGTCATAGCCTGGGCCATAGATTTTTGTTACTGC TAATCTTGCTTCTTAAAGTTCACACCCAGTGCAAAAAACCCAATCAGCAAACTAACCCCAAAATCCAATATATTTAGAAATGTAAGTGTT AAGAGATGTGCATTATGTACAAAATTGAAAATTGGTGCTAAAGTGGCAATGTCAATTTAAAATTTCTTGTCCAGATCTGACTGACTGACT CAGGAGATTATAGTTCCTACTCATTCTCTTTCCTTTTATCAGATCTTTCAAAAGCGCTTTTTAAAATTGATCAATGTGCAATTCTGTTTG AGTCTCTACAGTCCTATCCCTTTTGGAATGAACAGCTACACAAATAAATATTCTTGGAACTTCGAAGTTGTCTTCAAACTAGCTCTAGAA AATGTCCCTAGTTGACATTAGTGTTGGTCTGTTAGAAGGGGAAATTGATTTGACTGCTTCATGTTTTGAAAAGAGCATTAAGAGGGATTT GAGGAAGGTATATGTGGCTTTCTTTTTTTTTCTTAAGTTTGAATTACACTTGATTTCCTTTGGGTTATTAGGCAGATAAACCCTTGTCAT TAGTAATACTTAGCACTGTCCAAAATGAAAAATGACTGCCAGTGTGTTGCACATACATAAGAAAATTACATCTTACTGCGAAGTCTTTGG TTTGTTTCCTTATTTGGTTTGACTTTGACTTACTATTTTGCTATGGTCATATCCTTAATATCTGCGGTACATTTCATATATATATATGGG GTGGGAGCATAATTGCCATTCCCATGTGTCTCAAGGAAGCTTAATGAGGAAACTAATGAGTTAATATTAACTCTTCTGAAGAAAGCTGAC ATTTTAGGAGTATTAAGTCATCTGTCGTTAAGGAGCAGCAAGAATATATTATGATTGTATCACATGTTCCAGAAGAGCATTACCCCTTAC ATAGAAAGCTCCTTGGAGATTTCATGATGTTGGATGAACATCAGTTTATCCTTATACATCCCTATGAGCTATAATTATCCTCATTTGATA CTTGAGGAAACTGAAGTGACTTGCTCCAAAGTTGACTACAAAAACATTGCAGTTTGAGGCTTAGGTTGTAATCAGGTAATTTTGGTCTTG GACAGTAAGGGAAAATCCATAATACATAAAACACAAAAGTTTAGAAAGGGGGGGAAGTTGAGCTAGCAATGGGCATTTCTATTATTTAAG TTACATATCAGTTTCCAGGAATATTTTTCAAATGGGACAAACTAAAAAGTTGAGGACTAGAGCATCGTAGTGTCTAAGTGCACCTAATAA CTTAATGCATGTGCACACACCCTCAGTTAATTTGTAAGAGAGTGACTTCTCATTGTTATTTGTGGAGAGGCTAATTATAGTAGCTTCATT CTTTATTTTCTGTGTTCTTAAATTTTTTTTTACATTTGAAAGTATGAAAATACTATTTTTGACACTTTACTGATACTCAGGGATTAAAAG TTAAATTTTACTGACTGTAGCAGCAGGTAAATCTCTTAAATTTACTCAGGTTTCCTATCCTTTGCCTCCATATTTAAGAAAATATAGAAT GCCTGCCAGGGAAATATATAAAAATAAAAATTTCAAATACAATTTTAAAATACCAATTTGTAAATAAACCAATTTTACAAACTAAAATAT TGTGTCTTTCCTTGCTTTTTATCCCAATTTATCTCCCCTCCTAAGTTTGAGGAGTTTTATATATTAAGGCTATTTCTTCATTTGTAAAAA TGAAGTATGCTATTTGCAAAGCAAAAGCCCATGAAAAGCCCCAAATCATTTAAGTAAAGCTTACTGAATTGTTTTCAATTGTTTTGGGAG |
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FusionGenePPI for SMS_DYRK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMS | MAPK8IP2, MAPKAPK3, RPS6KA3, MAPK6, ELAVL1, KYNU, LACTB2, NUDCD2, CHORDC1, DDX39A, HSPD1, LDHA, SLC9A3R1, C11orf58, BCCIP, CSE1L, DAK, DPP3, GDA, LDHAL6B, NAGK, PDIA3, PROSC, YWHAB, YWHAQ, SORD, TP53RK, ENOPH1, HDLBP, MTRR, UBA6, UCHL3, NTRK1, XIAP, ATP6V1C1, ETFA, IGBP1, STXBP2, BAP1, PPP1R13L, HEATR3, PDRG1, PRRC2B, CMBL | DYRK2 | RAD54B, DCAF7, ATM, MDM2, UBR5, DDB1, VPRBP, HSPA5, HSPA1A, HSPA1B, HSPA8, DLST, XPNPEP3, RPS2, PDHB, RPL7, RPL4, HNRNPU, SSBP2, TUBA1C, RPLP0, NPM1, EEF1A1P5, SLC25A3, RPL7A, HSP90AA1, DAP3, TUBA3C, RBMXL2, RPA1, PCMT1, HSPA6, RPL18, KATNA1, SIAH2, APP, TERT, DYRK4, TTN, RB1CC1, NR1I2, SP100, IKZF1, KXD1, LZTS2, ZBTB9, WDR62, UBE2D1, DCAF5, TBK1, MOAP1, RNF8, RTN1, AKAP12, STK4, SAV1, KIF3C, KIF3B, CEP78, CCP110 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMS_DYRK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMS_DYRK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SMS | C0796160 | MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE | 5 | CTD_human;ORPHANET;UNIPROT |
| Hgene | SMS | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | SMS | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | SMS | C0236788 | Bipolar II disorder | 1 | PSYGENET |
| Hgene | SMS | C0525045 | Mood Disorders | 1 | PSYGENET |
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