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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34920

FusionGeneSummary for SMG7_SMG7

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG7_SMG7
Fusion gene ID: 34920
HgeneTgene
Gene symbol

SMG7

SMG7

Gene ID

9887

9887

Gene nameSMG7, nonsense mediated mRNA decay factorSMG7, nonsense mediated mRNA decay factor
SynonymsC1orf16|EST1C|SGA56MC1orf16|EST1C|SGA56M
Cytomap

1q25.3

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SMG7EST1 telomerase component homolog CEST1-like protein Cbreast cancer-associated antigen SGA-56Mever shorter telomeres 1Csmg-7 homolog, nonsense mediated mRNA decay factorprotein SMG7EST1 telomerase component homolog CEST1-like protein Cbreast cancer-associated antigen SGA-56Mever shorter telomeres 1Csmg-7 homolog, nonsense mediated mRNA decay factor
Modification date2018052320180523
UniProtAcc

Q92540

Q92540

Ensembl transtripts involved in fusion geneENST00000456731, ENST00000367537, 
ENST00000508461, ENST00000347615, 
ENST00000507469, ENST00000515829, 
ENST00000507406, 
ENST00000456731, 
ENST00000367537, ENST00000508461, 
ENST00000347615, ENST00000507469, 
ENST00000515829, ENST00000507406, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 2 X 1=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: SMG7 [Title/Abstract] AND SMG7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA598525SMG7chr1

183522990

-SMG7chr1

183522874

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000456731ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000456731ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000456731ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000456731ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000456731ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000456731ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000456731ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000367537ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000367537ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000367537ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000367537ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000367537ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000367537ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000367537ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000508461ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000508461ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000508461ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000508461ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000508461ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000508461ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000508461ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000347615ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000347615ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000347615ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000347615ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000347615ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000347615ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000347615ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000507469ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000507469ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000507469ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000507469ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000507469ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000507469ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000507469ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000515829ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000515829ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000515829ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000515829ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000515829ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-3UTRENST00000515829ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
3UTR-intronENST00000515829ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000507406ENST00000456731SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000507406ENST00000367537SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000507406ENST00000508461SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000507406ENST00000347615SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000507406ENST00000507469SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-3UTRENST00000507406ENST00000515829SMG7chr1

183522990

-SMG7chr1

183522874

+
intron-intronENST00000507406ENST00000507406SMG7chr1

183522990

-SMG7chr1

183522874

+

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FusionProtFeatures for SMG7_SMG7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMG7

Q92540

SMG7

Q92540


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SMG7_SMG7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SMG7_SMG7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMG7_SMG7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMG7_SMG7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource