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Fusion gene ID: 3489 |
FusionGeneSummary for ATP6V1H_ST8SIA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP6V1H_ST8SIA4 | Fusion gene ID: 3489 | Hgene | Tgene | Gene symbol | ATP6V1H | ST8SIA4 | Gene ID | 51606 | 7903 |
| Gene name | ATPase H+ transporting V1 subunit H | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | |
| Synonyms | CGI-11|MSTP042|NBP1|SFD|SFDalpha|SFDbeta|VMA13 | PST|PST1|SIAT8D|ST8SIA-IV | |
| Cytomap | 8q11.23 | 5q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | V-type proton ATPase subunit HATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit HV-ATPase 50/57 kDa subunitsV-ATPase subunit Hnef-binding protein 1protein VMA13 homologvacuolar ATP synthase subunit Hvacuolar ATPase subunit Hvacuolar proton p | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferaseCMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferaseSIAT8-DST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4ST8SiaIValpha-2,8-sialyltransferase 8Dpolysialyltransferase-1sialyltr | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9UI12 | Q92187 | |
| Ensembl transtripts involved in fusion gene | ENST00000355221, ENST00000520188, ENST00000359530, ENST00000523899, ENST00000396774, | ENST00000231461, ENST00000451528, ENST00000507360, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 3=48 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ATP6V1H [Title/Abstract] AND ST8SIA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP6V1H | GO:0006897 | endocytosis | 12032142 |
| Tgene | ST8SIA4 | GO:0001574 | ganglioside biosynthetic process | 10766765 |
| Tgene | ST8SIA4 | GO:0006486 | protein glycosylation | 10766765 |
| Tgene | ST8SIA4 | GO:0006491 | N-glycan processing | 10766765 |
| Tgene | ST8SIA4 | GO:0009311 | oligosaccharide metabolic process | 10766765 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A3OD-01B | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000355221 | ENST00000231461 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| intron-3CDS | ENST00000355221 | ENST00000451528 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| intron-intron | ENST00000355221 | ENST00000507360 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| In-frame | ENST00000520188 | ENST00000231461 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| In-frame | ENST00000520188 | ENST00000451528 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| 5CDS-intron | ENST00000520188 | ENST00000507360 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| Frame-shift | ENST00000359530 | ENST00000231461 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| Frame-shift | ENST00000359530 | ENST00000451528 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| 5CDS-intron | ENST00000359530 | ENST00000507360 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| intron-3CDS | ENST00000523899 | ENST00000231461 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| intron-3CDS | ENST00000523899 | ENST00000451528 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| intron-intron | ENST00000523899 | ENST00000507360 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| Frame-shift | ENST00000396774 | ENST00000231461 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| Frame-shift | ENST00000396774 | ENST00000451528 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
| 5CDS-intron | ENST00000396774 | ENST00000507360 | ATP6V1H | chr8 | 54723724 | - | ST8SIA4 | chr5 | 100231489 | - |
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FusionProtFeatures for ATP6V1H_ST8SIA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP6V1H | ST8SIA4 |
| Subunit of the peripheral V1 complex of vacuolar ATPase.Subunit H activates the ATPase activity of the enzyme and couplesATPase activity to proton flow. Vacuolar ATPase is responsible foracidifying a variety of intracellular compartments in eukaryoticcells, thus providing most of the energy required for transportprocesses in the vacuolar system (By similarity). Involved in theendocytosis mediated by clathrin-coated pits, required for theformation of endosomes. {ECO:0000250}. | Catalyzes the polycondensation of alpha-2,8-linkedsialic acid required for the synthesis of polysialic acid (PSA),which is present on the embryonic neural cell adhesion molecule(N-CAM), necessary for plasticity of neural cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP6V1H_ST8SIA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000231461_chr5_100231489_-_475aa MISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPML NRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDRWXIVFESVTCQXLXXNHSKGWLFNLP AQCRRLENQFLFGPRDKEEHTSFLRCRTRCVSGQEQFXAWXCHTLCAXQAPDTKHFSXSTXPPTXSFTNEESQVXDLCSCWKFWHSVRQX MWKGDXQSQFCNKVXSSSCGGVCCRCGNXIRFYYHESISCTKSIWRLSKXEXQRKICAXTFHAEXQCPLDSCFHGQRRREARGVGXCINP XEXTESANCLSVIETYSCCQRLLADQQSSYQKTQHRSSHVYTCHKILXXNSPVWILALPXGFKWKSGQISLLXXLKIXVLFQCKPSQNAI >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000451528_chr5_100231489_-_284aa MISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPML NRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDRWXIVFESVTCQXLXXNHSKGWLFNLP AQCRRLENQFLFGPRDKEEHTSFLRCRTRCVSGQEQFXAWXCHTLCAXQAPDTKHFSXSTXPPTXSFTNEESQVXDLCSCWKFWHSVRQX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000231461_chr5_100231489_-_1426nt ATGATTTCTGCTGAAGATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAAGAGAAGCAAGAGATGCTTCAAACTGAAGGC AGCCAGTGTGCTAAAACATTTATAAATCTGATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATG CTGCAGGAAAATCATCAGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAACACTGCGTGGCCCTACTTTCTGCCAATGTTG AATCGCCAGGATCCCTTCACTGTTCATATGGCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGAC TTAAATTACTATTTCAATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGCGGTGTTGCTGTTGAAACAGGAACAGTCTCT TCAAGTGATAGATGGTGAATTGTCTTTGAGTCGGTCACTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATCTTCCA GCACAATGTAGAAGGTTGGAAAATCAATTCCTCTTTGGTCCTAGAGATAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGT GTCAGTGGTCAAGAGCAGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGACAGGCGCCGGACACTAAACATTTCTCATGATCTACA TAGCCTCCTACCTGAAGTTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAAATTCTGGCATTCTGTTAGACAGTGA ATGTGGAAAGGAGATTGACAGTCACAATTTTGTAATAAGGTGTAATCTAGCTCCTGTGGTGGAGTTTGCTGCAGATGTGGGAACTAAATC AGATTTTATTACCATGAATCCATCAGTTGTACAAAGAGCATTTGGAGGCTTTCGAAATGAGAGTGACAGAGAAAAATTTGTGCATAGACT TTCCATGCTGAATGACAGTGTCCTTTGGATTCCTGCTTTCATGGTCAAAGGAGGAGAGAAGCACGTGGAGTGGGTTAATGCATTAATCCT TAAGAATAAACTGAAAGTGCGAACTGCCTATCCGTCATTGAGACTTATTCATGCTGTCAGAGGTTACTGGCTGACCAACAAAGTTCCTAT CAAAAGACCCAGCACAGGTCTTCTCATGTATACACTTGCCACAAGATTCTGTGATGAAATTCACCTGTATGGATTCTGGCCCTTCCCTAA GGATTTAAATGGAAAAGCGGTCAAATATCATTATTATGATGACTTAAAATATAGGTACTTTTCCAATGCAAGCCCTCACAGAATGCCATT >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000451528_chr5_100231489_-_853nt ATGATTTCTGCTGAAGATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAAGAGAAGCAAGAGATGCTTCAAACTGAAGGC AGCCAGTGTGCTAAAACATTTATAAATCTGATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATG CTGCAGGAAAATCATCAGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAACACTGCGTGGCCCTACTTTCTGCCAATGTTG AATCGCCAGGATCCCTTCACTGTTCATATGGCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGAC TTAAATTACTATTTCAATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGCGGTGTTGCTGTTGAAACAGGAACAGTCTCT TCAAGTGATAGATGGTGAATTGTCTTTGAGTCGGTCACTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATCTTCCA GCACAATGTAGAAGGTTGGAAAATCAATTCCTCTTTGGTCCTAGAGATAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGT GTCAGTGGTCAAGAGCAGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGACAGGCGCCGGACACTAAACATTTCTCATGATCTACA TAGCCTCCTACCTGAAGTTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAAATTCTGGCATTCTGTTAGACAGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000231461_chr5_100231489_-_6682nt AATGCAGAGAGCTGAGGCTAGAGAGGCAGCCAGGGGCCGATCGTGAAGATGCTGTGTGTGGGTGTGTGGTTGGAAGGAGTTTGGACTTGA TCCTATCAGTCAGTGCTTTTCAAGCTGATTTTTAAGCTGTGAAGCCCATGATTGATATGAAGTTAGCATGTAAAACAGATGAAAATGATA GAATGGAGGTGGGAGTGTGTGTCCCAGAGCCCTCTTTTTGAGACCATTCACCATTTTCCAAGGAGCTGTAGGTGTTGGAAACCAATGAAT CTTGTAGCCGGGAGTTAGAAGACCATATCTGCCTCTTGATTGAATTGTTCTACTAGCAGCATGAAGGGGGACAGATGATTTCTGCTGAAG ATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAAGAGAAGCAAGAGATGCTTCAAACTGAAGGCAGCCAGTGTGCTAAAA CATTTATAAATCTGATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATGCTGCAGGAAAATCATC AGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAACACTGCGTGGCCCTACTTTCTGCCAATGTTGAATCGCCAGGATCCCT TCACTGTTCATATGGCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGACTTAAATTACTATTTCA ATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGCGGTGTTGCTGTTGAAACAGGAACAGTCTCTTCAAGTGATAGATGGT GAATTGTCTTTGAGTCGGTCACTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATCTTCCAGCACAATGTAGAAGGT TGGAAAATCAATTCCTCTTTGGTCCTAGAGATAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGTGTCAGTGGTCAAGAGC AGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGACAGGCGCCGGACACTAAACATTTCTCATGATCTACATAGCCTCCTACCTGAA GTTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAAATTCTGGCATTCTGTTAGACAGTGAATGTGGAAAGGAGATT GACAGTCACAATTTTGTAATAAGGTGTAATCTAGCTCCTGTGGTGGAGTTTGCTGCAGATGTGGGAACTAAATCAGATTTTATTACCATG AATCCATCAGTTGTACAAAGAGCATTTGGAGGCTTTCGAAATGAGAGTGACAGAGAAAAATTTGTGCATAGACTTTCCATGCTGAATGAC AGTGTCCTTTGGATTCCTGCTTTCATGGTCAAAGGAGGAGAGAAGCACGTGGAGTGGGTTAATGCATTAATCCTTAAGAATAAACTGAAA GTGCGAACTGCCTATCCGTCATTGAGACTTATTCATGCTGTCAGAGGTTACTGGCTGACCAACAAAGTTCCTATCAAAAGACCCAGCACA GGTCTTCTCATGTATACACTTGCCACAAGATTCTGTGATGAAATTCACCTGTATGGATTCTGGCCCTTCCCTAAGGATTTAAATGGAAAA GCGGTCAAATATCATTATTATGATGACTTAAAATATAGGTACTTTTCCAATGCAAGCCCTCACAGAATGCCATTAGAATTCAAAACATTA AATGTGCTACATAATAGAGGAGCTCTAAAACTGACAACAGGAAAGTGTGTAAAGCAATAAAGCACATTTTGAAACAAACAATATGCACTT CTTTTCTGAAGATGCTTCCGAAGATTTGAAAATAGGATCCAAAACACGGCTGGGTTTCAGCATCCACCAATGAACTGAAAGGTGAATAAA GGACGTTCATGAGAAATCGACTACCAGCTGATGAAATACCTGCAAAGTGCTCTAAAAATTAAATATTTTGACTTTAAGGGTCCTAGTAAG TGCCACTTCCACTAAGAATACAGTTTGAATGTATAATCAGTAGTGTTTACAAGATCCAACAGTGCACTCATCATTAGTTAACAAAGCAAA TATGTTCATCACTGTCAGGCTGCCCACAGCAACACCAAGCATATTAGAAGAGGAACCCCAGGAACGCAACTCAGACCTTGGGAAATTAAA CCATCCTTGTCAGCAGAAGCCAAGATGGAAGCAGTTTGAGCAATGAAATCCGTAAGATTAAACAACTCAAGTAAATGCTTCAGTCAGGAC TCTGAGTCTGATCATGAATTTTATGTTTTAATTTATGTTTTTTTTTTGTCTTCTGGAATCTCTTTTGGTTTGGATATTGGGATGCTTAGA AATCCTTTCTGAGATGCATATGAGTGAGGAAATAAACTTTAAGTAATTATTTTTAAAGTTCTTATACTTTTTAAAAGCTATCACACAAAG ACTTTTTTTTTTTTTTTTGTCTCGCTCTGTTGCCCAGGCTGGAGTACAGTGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCAAGTT CACTCCATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTGCAGGCGCCTGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAG ACGGATTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGG CGTGAGCCACCGTGCCTGGCCGACATTTTTAAAAAAGTTTTATTTTGCACGGCTCTAAACCTCCATGTTATTTTCCAGTGGTGTAGAAGG TACCAGCTAAAGTGAACCACTATGTAATATTAGGCCATTCTAAAGGAAAGATGTTCCATGTCATCAGAGATGGTAAAATAGGCCGGGAAA AAAAAATCTTTGGTACCAAAGATTACACTTGTGTTTCTACACAGCAAACCATTTTTCTTTCATGAAAATAATATATTATTAACATGAATA TATTATTTTGCTATTAATGTGAAAGTTGTCTCTAAATATTTTTTAATTTTCAAACTCATACTTTATTTTCATTTGAAATGTTTTTCACAC CTTTTGCATTACATAATAATTTTGTGGAAGCATTTTGCCCTTTAGAATAAATATTAGATTGATATAGCTGAAATGTGACTTCCAGTTCTT TGATATTCCCCTTGTTATTCAAATAGAAATATGGAAATGCTTTATATATTACTGTTAAATTTCTTAGTGCAGAAATAACATTATTAATAG AGTATTGTTTTCAAAACAGAGATGATTAATTTCAAGAGGTTTAACAGTGAAATTGTGTCAATATTTTGCATTTAAAATGAATTTAATTGA CCGATATTTTCTGTAGTTAAATTTAGTCACAATATCACATATGTTCTTCAAGAAACACATGAAATTATTAATAAAGTAATTAAAAAATTT TTAATGTATAACAGAATTGACCAATAGGCCAGTTTTCTGGTAACTTATGATAGTAGATTGTTTCTTTAGAAACTGGGCAGAAGCTCTGCA TTCTCACTTGTACTTTGATTTCTTATTTCTTGGGCAGGCAATTTGAGGAAAGAAGAAATGGCATGGGGAATATATATGTTTTGTTTCTTA GGGAAAACAGTCTGAGAAATGAATAAAAAGCATGAAGTACGTGTGTGTGTGTGTGTGTTACCATGGAAAAGGATATTCACAGTAGTACAG TTCTCAATATTTTTAATTAGATGTCATATTTTTTTAATATAGTAAAACCTTGGGATATAGAATATTACATCTTTTGAGAATGTATGTGTC TCTAAGTAAGTAAAATCTAATGCGTATAGGAGACTGATAGCTAAAAATGAATGGAACATTAATGTACTTTTATAATTAAACCTCTTATCT ATCAGAAATTGTAAGAGAATAGATACATGTTTTGAATGTAAAGTTGAAAAGTCTGGTTTACTTAATAAATTGAAAGTGATTTATAAAATC TAAATTTGGACTACTTGCAAATGATAAGCTATTCTAGTAGCCTTTAGTTTAAATCCAACAGAAATCTAGAAGTCACAAGCAAATATCTTA AAGGTAAAATCCATCTGGGCACTCATTTAAAGTATATCTTAAAAAAGCAGCAGCAAGGTACCTTGCCATTTTTAGCATATTTTCTTCCTT TTTCTTTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACACAGGCTGGAATGCAGTGATGCCATCTCAGCTCACTGCAA CCTCCACCTCCTGGGTTCAAGTGATTCTCGTGCCTCAGCCTCCCAAGTAGCTGGGGTTACAGGCGCCCACCACCACACTCGGCTAATTTT GTGTTTTTAGTAGAGACAAAGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTTCCTGACCTCAGGTTATCCACCCACCTCAGCCTCCCA AAGTGCTGGGATTACAGGTGTGAGCCACCGCAGCCGGACCATTTTTAGTATATTTTCAGTAAATACATTTAAACAATGTTAAGGCCACAG CACACATATCTCAGCCATTCATTGTTCTGTGCATTGATGTTTATCTCATAGATGCATTGAGTAGTGCCTTTTTAGCTTTTTCACATTACT TTGTCACCATATCCTTTGTGTTCTCTAAATACATTGCCCACTTCCAAAAATGTTCAGCATGAAAAAAAGGGCTTCAGTGTCGATTGAGAT TGCTTTTGTTCATCTCAGGGATTTCAATAGTCAAGAATGAATTCAGTTAAAGGTATTTAGGGTTCAAAGAAGACAAACTGTACAAGCCCA TTTCATTCCTTGTTGTATACCTTTCCATCTGCCCTCCCATTTTAACTATCTACTGTGGCCTTTTTATGGAAACAGAGCAAGATCAATGAA GGCTAATGGCAAGAATAAGAAAAAGAGTTGAGATTTAACCAATAGCGGAGCATAAAGGATCATGACAAAATCAAATTATAAAAGCATACT TGAAATAGGTGGAGCTTTTTCTTTTGAAAATATATATTCACAATTTTAATATTTTAATTTATTTTTTACTATTTAACCCTGTACTTGGCA ATGCTCAGGCAGCTGATTGTGAAATATTCTTGTCCTTTACAGAACATGGTTGTTATTGTGCTGTTGACATGAATAGACCATGGAAACATT TTCATCATTATTATTCAGCCTGTGCTGTAGTTAATGTTAAGTTGCTGAAATAAAAAGTGAGCAAGTAATAGATTTTCTTGGCAAATCTAA TGATTCAGCCCACAGGACTGTTGAAACTACTGCGGAAGTTTTTCTATCTGAAAGAAGGTGCTGGGCATTCAAATGTGTTCATGTATTGTA TATCATATGAATTGTATATCAATTACTAATGGGAATTTCTACATATATGCTTACAAAAGCAATTTATTTAAGTAATGCTAGGGGTAGTGT ACATACCAATTAGTTATTCAGCTACTATACAGAAAAAGGATGAACAAATTAATTTATTTCTAATTGAGCCAGTTAGACATAATGCATATA ACGTGATATTTGGTTCATGAAAGAGTTGTTTTCATGTGGTTATTGTAGGGAGTATATATAATTGTGGAAGGGGTATGGGAAGAGTTGTGT ATAGTTAGTTGTTATCTCTACAAGTTTGAAAGTTTTCCCATCAAACATTATCAATATACCAATGTTTTAAAAATTGAGTGAGGGTTATTA TTTGTATTTGATGAAAGAAAATCCAAATAAAGCCCACCTAGAAATAGATATTTTATTATATATGTGCTATAGATATACCTATATAGTACA AATAGACATGTGTGATGCATATATACAATGTTATATATGTGTATATGTCTGTATACACACTGAGTCTGTAATATGTATACACTAAATTTG TGTTATGCTAACATCTTCAGGGTCTGCACTGTGAACTCCCCTGGAGATAAGTAAGTCCACTTTAGAATAAAGAAGTTCTTTTGAGACTTC AGTTACTAACGTGCTTTAAGAGGTATCTACTTTATAACTGAATTCTATGTCGTTCATACGTAGAGTTACAGTAAGGGTCTAGTATGTCCA AATCTTAATAATAAAGAAGAAAAGTAAAGGCTTCAAGCTAGCAATGTATTCGAATTACAGTTTTCAGATTGTGGCTCCAGGCCTTGTGTT TCTCATTTAAGTAGCACCTTTTAATAAAAACCGTTTCTTTGTGTAGGCAAAAGCACAAGTGTTTCAAATGTAAATAGCAGGAAAAAAAAA GAGTTTACAGAGATAGCATTGCTGCACAGAATAATTGCTACTGAGTATTTCTTATAGAATTTGTGGAACTGAAAGATGAGGTTTATTCTG TCAAGTTCAAGTTCATTCTGTTCAACACTGTTTTCTTATTGTTTGTGTATAGCAACCGGGTATTATTGTTTTATCATTTGTAAAATTGTA AAATAAATTAATCCCTTTTTTTCACTGTTTCTCTTATCTCATATATCCAAGCCCTTGGTTATACTTTGTATGTCAATGTTAGGTGATCAT TTTTAACAAGCTTTGGCTTGTGCTTTGCTTTTCCACTCCCCTTAGCCCTAGTGGTTGGCAATTAGGCAAACCATTTATTTTTAAGTGTAT ACATGGGAATATGAACAATGTCAAAAACCCCATGAATATTAGGAAATCCTTAACGATATTTTGTGTAGCACATTCTGTTTGCGGTTGAGG >In-frame_ATP6V1H_ENST00000520188_chr8_54723724_-_ST8SIA4_ENST00000451528_chr5_100231489_-_2225nt AATGCAGAGAGCTGAGGCTAGAGAGGCAGCCAGGGGCCGATCGTGAAGATGCTGTGTGTGGGTGTGTGGTTGGAAGGAGTTTGGACTTGA TCCTATCAGTCAGTGCTTTTCAAGCTGATTTTTAAGCTGTGAAGCCCATGATTGATATGAAGTTAGCATGTAAAACAGATGAAAATGATA GAATGGAGGTGGGAGTGTGTGTCCCAGAGCCCTCTTTTTGAGACCATTCACCATTTTCCAAGGAGCTGTAGGTGTTGGAAACCAATGAAT CTTGTAGCCGGGAGTTAGAAGACCATATCTGCCTCTTGATTGAATTGTTCTACTAGCAGCATGAAGGGGGACAGATGATTTCTGCTGAAG ATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAAGAGAAGCAAGAGATGCTTCAAACTGAAGGCAGCCAGTGTGCTAAAA CATTTATAAATCTGATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATGCTGCAGGAAAATCATC AGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAACACTGCGTGGCCCTACTTTCTGCCAATGTTGAATCGCCAGGATCCCT TCACTGTTCATATGGCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGACTTAAATTACTATTTCA ATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGCGGTGTTGCTGTTGAAACAGGAACAGTCTCTTCAAGTGATAGATGGT GAATTGTCTTTGAGTCGGTCACTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATCTTCCAGCACAATGTAGAAGGT TGGAAAATCAATTCCTCTTTGGTCCTAGAGATAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGTGTCAGTGGTCAAGAGC AGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGACAGGCGCCGGACACTAAACATTTCTCATGATCTACATAGCCTCCTACCTGAA GTTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAAATTCTGGCATTCTGTTAGACAGTGAATGTGGAAAGGAGATT GACAGTCACAATTTTGTAATAAGGTGAGCTTTCTTCTGCTTTTTGAGATTGTAAGTTTTTCAAAGATATTTTACTTGGGGGTGGAAAACT GTTAGAAAATTTTAAAGTATTACTAAAACCTCAAACAAATATTTGTCTATGATATCCTTTTCTGTGCAACATTTAAATTACATTTACCCT GGAATAGAATATTATAATTATTGCGTAGTTGAAAGAAAAAGTGATCCTGTCATAGCAACAAGATTCACACAGCTTTTTTTGGTGAGGTGA GGGGGGAGGCAAATGGCAATTTTATTAAATTTAATATTCCACACAAACTTTTTTCTTAGTATCTCTTCTTCATACTCATTAGTTTTGTGT GATTTTATTTGTTGTATAAAGATTATGAATATTACTATGGAATGATGTAATAGATTTATGTTAATGTTACTTTTTATTAATAATTATCTA GGAGATAGTAAGAACATAGTTTAGCAAGTTTATATTTGATATCCTGAGCCATATTTCTTTAATTTCTCTTTATATGTGGTATTTGTGTAT GTTAGTATATTTGAATTTTATGTTTTTTTAACATAATTAAGCGTGCATGTTTGTTTTTCATTAACGGTTAAAAGATATTTGATGAATTGT GTGTTTGATTAACCTATTAACTGAAAAAAACTCAACAGTAGAAATGGAATTATAATCACATCATAAATATAAGCAGTTTTTAATGATCAA TTTTTATATCTGTACAGTTTTTTTGGATTGTTTTAGTTCCTTAGAAAAATTAGCTAAATGACAGAAACATGGATATTGAAATATGAAATA GTACAATATAAAGATAGATAGAAAAGTATGCTGAGTTGACATGTTGAAAAACACAGTCTCTTGAAGATATACTGGAATACATTATTTTTG AATATTTTGAATATTTTTTGAATATTTTTAAATAAAGTCTTAAAAGCATAAATAGGTAACTACTTTTAAAAAAAAAGTCATGAGAAATCA |
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FusionGenePPI for ATP6V1H_ST8SIA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP6V1H | ATP6V1E1, ATP6V1B1, ATP6V1D, ATP6V1F, ATP6V1B2, RAB11B, RMDN3, VDAC2, HNRNPUL1, UBE2N, ZMPSTE24, DDX28, VDAC3, PROCR, ZFAND5, ATP5F1, UBQLN1, SORBS3, ABCC1, EEF2, USP3, EGFR, SOX9, TANK, GMPPB, PDXDC1, USP47, WDR44, UNK, C6orf211, ATP6V0D1, ATP6V1A, MRPL1, CDC42, HSD17B10, STMN1, MED20, RAB2A, GOLT1B, ARMC6, NF2, FAF2, MAS1, TES | ST8SIA4 | PTCH1, DNASE1L1, SUSD1, ITGA7, TGFBR3, SCGB2A2, ADAMTS2, RNASEL, SEMA4D, PLXNA2, GALNT18, STK39, CNTNAP3, FAM69A, AMIGO1, RUFY1, BACE2, PRKD2, ITGB5, LNPEP, PLXNB2, B4GALNT1, LRP5, NLGN2, HLA-C, TUBA4A, PLXNA1, FREM2, ITGA4, TMEM67, EPHB4, BCAM, TUBB3, MRC2, NRP2, ITGA8, CACHD1, TCTN2, GPR98, FRAS1, GYLTL1B, ITGAV, CELSR2, CLSTN3, ACTA2, NDST2, HYAL2, IMPAD1, PON2, KIAA0319L, CBWD1, EGFR, TMEM132A, PTGFRN, TUFM, LRP6, ADAM17, OAF, CD109, MR1, TMBIM6, ITPRIP, LRP11, FAT1, NRP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP6V1H_ST8SIA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP6V1H_ST8SIA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ST8SIA4 | C0036341 | Schizophrenia | 1 | PSYGENET |
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