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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3480

FusionGeneSummary for ATP6V1G1_ATP6V1G1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP6V1G1_ATP6V1G1
Fusion gene ID: 3480
HgeneTgene
Gene symbol

ATP6V1G1

ATP6V1G1

Gene ID

9550

9550

Gene nameATPase H+ transporting V1 subunit G1ATPase H+ transporting V1 subunit G1
SynonymsATP6G|ATP6G1|ATP6GL|ATP6J|Vma10ATP6G|ATP6G1|ATP6GL|ATP6J|Vma10
Cytomap

9q32

9q32

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase subunit G 1ATPase, H+ transporting, lysosomal (vacuolar proton pump), member JATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1V-ATPase 13 kDa subunit 1V-ATPase subunit G 1vacuolar ATP synthase subunit M16vacuolar H(+)-ATPV-type proton ATPase subunit G 1ATPase, H+ transporting, lysosomal (vacuolar proton pump), member JATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1V-ATPase 13 kDa subunit 1V-ATPase subunit G 1vacuolar ATP synthase subunit M16vacuolar H(+)-ATP
Modification date2018052220180522
UniProtAcc

O75348

O75348

Ensembl transtripts involved in fusion geneENST00000374050, ENST00000473413, 
ENST00000374050, ENST00000473413, 
Fusion gene scores* DoF score5 X 4 X 3=601 X 1 X 1=1
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/1*10)=4.32192809488736
Context

PubMed: ATP6V1G1 [Title/Abstract] AND ATP6V1G1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA449988ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+
ChiTaRS3.1CB852306ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000374050ENST00000374050ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+
3UTR-intronENST00000374050ENST00000473413ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+
intron-3CDSENST00000473413ENST00000374050ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+
intron-intronENST00000473413ENST00000473413ATP6V1G1chr9

117360191

-ATP6V1G1chr9

117359947

+

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FusionProtFeatures for ATP6V1G1_ATP6V1G1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP6V1G1

O75348

ATP6V1G1

O75348

Catalytic subunit of the peripheral V1 complex ofvacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifyinga variety of intracellular compartments in eukaryotic cells. Inaerobic conditions, involved in intracellular iron homeostasis,thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD)enzymes, and leading to HIF1A hydroxylation and subsequentproteasomal degradation (PubMed:28296633).{ECO:0000269|PubMed:28296633}. Catalytic subunit of the peripheral V1 complex ofvacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifyinga variety of intracellular compartments in eukaryotic cells. Inaerobic conditions, involved in intracellular iron homeostasis,thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD)enzymes, and leading to HIF1A hydroxylation and subsequentproteasomal degradation (PubMed:28296633).{ECO:0000269|PubMed:28296633}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP6V1G1_ATP6V1G1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP6V1G1_ATP6V1G1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP6V1G1_ATP6V1G1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP6V1G1_ATP6V1G1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource