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Fusion gene ID: 34711 |
FusionGeneSummary for SLTM_ADM |
Fusion gene summary |
Fusion gene information | Fusion gene name: SLTM_ADM | Fusion gene ID: 34711 | Hgene | Tgene | Gene symbol | SLTM | ADM | Gene ID | 79811 | 133 |
Gene name | SAFB like transcription modulator | adrenomedullin | |
Synonyms | Met | AM|PAMP | |
Cytomap | 15q22.1 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | SAFB-like transcription modulatormodulator of estrogen-induced transcription | ADMpreproadrenomedullinproadrenomedullin N-20 terminal peptide | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NWH9 | P35318 | |
Ensembl transtripts involved in fusion gene | ENST00000380516, ENST00000536328, ENST00000557950, | ENST00000278175, ENST00000534464, ENST00000530439, ENST00000524948, ENST00000528655, ENST00000526492, ENST00000525063, ENST00000528544, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 3 X 3 X 1=9 |
# samples | 7 | 3 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLTM [Title/Abstract] AND ADM [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADM | GO:0001570 | vasculogenesis | 16964401 |
Tgene | ADM | GO:0002031 | G-protein coupled receptor internalization | 10882736 |
Tgene | ADM | GO:0003073 | regulation of systemic arterial blood pressure | 18434369 |
Tgene | ADM | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | 10882736|18434369|20074556 |
Tgene | ADM | GO:0010460 | positive regulation of heart rate | 18434369 |
Tgene | ADM | GO:0031623 | receptor internalization | 10882736|15613468|20074556 |
Tgene | ADM | GO:0035809 | regulation of urine volume | 18434369 |
Tgene | ADM | GO:0045906 | negative regulation of vasoconstriction | 11410113 |
Tgene | ADM | GO:1990410 | adrenomedullin receptor signaling pathway | 10882736|18434369|20074556 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW452874 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000380516 | ENST00000278175 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000380516 | ENST00000534464 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000380516 | ENST00000530439 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000380516 | ENST00000524948 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000380516 | ENST00000528655 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000380516 | ENST00000526492 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000380516 | ENST00000525063 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000380516 | ENST00000528544 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000278175 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000536328 | ENST00000534464 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000536328 | ENST00000530439 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000524948 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000528655 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000526492 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000525063 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000536328 | ENST00000528544 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000278175 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000557950 | ENST00000534464 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-5UTR | ENST00000557950 | ENST00000530439 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000524948 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000528655 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000526492 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000525063 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
intron-intron | ENST00000557950 | ENST00000528544 | SLTM | chr15 | 59171958 | + | ADM | chr11 | 10327348 | - |
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FusionProtFeatures for SLTM_ADM |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SLTM | ADM |
AM and PAMP are potent hypotensive and vasodilatatoragents. Numerous actions have been reported most related to thephysiologic control of fluid and electrolyte homeostasis. In thekidney, am is diuretic and natriuretic, and both am and pampinhibit aldosterone secretion by direct adrenal actions. Inpituitary gland, both peptides at physiologically relevant dosesinhibit basal ACTH secretion. Both peptides appear to act in brainand pituitary gland to facilitate the loss of plasma volume,actions which complement their hypotensive effects in bloodvessels. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLTM_ADM |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLTM_ADM |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLTM_ADM |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLTM_ADM |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADM | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Tgene | ADM | C0017658 | Glomerulonephritis | 2 | CTD_human |
Tgene | ADM | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
Tgene | ADM | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | ADM | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | ADM | C0020429 | Hyperalgesia | 1 | CTD_human |
Tgene | ADM | C0030193 | Pain | 1 | CTD_human |
Tgene | ADM | C0038358 | Gastric ulcer | 1 | CTD_human |
Tgene | ADM | C0243026 | Sepsis | 1 | CTD_human |