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Fusion gene ID: 34697 |
FusionGeneSummary for SLK_INA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLK_INA | Fusion gene ID: 34697 | Hgene | Tgene | Gene symbol | SLK | INA | Gene ID | 9748 | 9118 |
| Gene name | STE20 like kinase | internexin neuronal intermediate filament protein alpha | |
| Synonyms | LOSK|STK2|bA16H23.1|se20-9 | NEF5|NF-66|TXBP-1 | |
| Cytomap | 10q24.33-q25.1 | 10q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | STE20-like serine/threonine-protein kinaseCTCL tumor antigen se20-9Long Ste20-like KinaseSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinaseSNF1 sucrose nonfermenting like kinaseSTE20-related kinaseSTE20- | alpha-internexin66 kDa neurofilament proteinalpha-Inxneurofilament 5 (66kD)neurofilament-66, tax-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H2G2 | Q16352 | |
| Ensembl transtripts involved in fusion gene | ENST00000369755, ENST00000335753, ENST00000474260, | ENST00000369849, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 1 X 3=12 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLK [Title/Abstract] AND INA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLK | GO:0042981 | regulation of apoptotic process | 22203681 |
| Hgene | SLK | GO:0046777 | protein autophosphorylation | 18239682 |
| Hgene | SLK | GO:0051893 | regulation of focal adhesion assembly | 23128389 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YJ-A8SW-01A | SLK | chr10 | 105727653 | + | INA | chr10 | 105046792 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369755 | ENST00000369849 | SLK | chr10 | 105727653 | + | INA | chr10 | 105046792 | + |
| In-frame | ENST00000335753 | ENST00000369849 | SLK | chr10 | 105727653 | + | INA | chr10 | 105046792 | + |
| intron-3CDS | ENST00000474260 | ENST00000369849 | SLK | chr10 | 105727653 | + | INA | chr10 | 105046792 | + |
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FusionProtFeatures for SLK_INA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLK | INA |
| Class-IV neuronal intermediate filament that is able toself-assemble. It is involved in the morphogenesis of neurons. Itmay form an independent structural network without the involvementof other neurofilaments or it may cooperate with NF-L to form thefilamentous backbone to which NF-M and NF-H attach to form thecross-bridges. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 16_19 | 50 | 1205 | Compositional bias | Note=Poly-Lys |
| Hgene | SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 16_19 | 50 | 1236 | Compositional bias | Note=Poly-Lys |
| Hgene | SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 40_48 | 50 | 1205 | Nucleotide binding | ATP |
| Hgene | SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 40_48 | 50 | 1236 | Nucleotide binding | ATP |
| Tgene | >INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 449_454 | 355 | 500 | Compositional bias | Note=Poly-Glu |
| Tgene | >INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 409_499 | 355 | 500 | Region | Note=Tail |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 1109_1183 | 50 | 1205 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 826_1069 | 50 | 1205 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 1109_1183 | 50 | 1236 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 826_1069 | 50 | 1236 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 302_652 | 50 | 1205 | Compositional bias | Note=Glu-rich |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 302_652 | 50 | 1236 | Compositional bias | Note=Glu-rich |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 34_292 | 50 | 1205 | Domain | Protein kinase |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000335753 | + | 1 | 18 | 875_910 | 50 | 1205 | Domain | UVR |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 34_292 | 50 | 1236 | Domain | Protein kinase |
| Hgene | >SLK | chr10:105727653 | chr10:105046792 | ENST00000369755 | + | 1 | 19 | 875_910 | 50 | 1236 | Domain | UVR |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 94_407 | 355 | 500 | Domain | IF rod |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 130_142 | 355 | 500 | Region | Note=Linker 1 |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 143_238 | 355 | 500 | Region | Note=Coil 1B |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 1_87 | 355 | 500 | Region | Note=Head |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 239_262 | 355 | 500 | Region | Note=Linker 2 |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 263_408 | 355 | 500 | Region | Note=Coil 2 |
| Tgene | INA | chr10:105727653 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 88_129 | 355 | 500 | Region | Note=Coil 1A |
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FusionGeneSequence for SLK_INA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLK_ENST00000369755_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_195aa MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAA YRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTE >In-frame_SLK_ENST00000335753_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_195aa MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAA YRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLK_ENST00000369755_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_585nt ATGTCCTTCTTCAATTTCCGTAAGATCTTCAAGTTGGGGAGCGAGAAGAAGAAGAAGCAGTACGAACACGTGAAGAGGGACCTGAACCCC GAAGACTTTTGGGAGATTATAGGAGAACTGGGCGACGGAGCCTTTGGGAAAGTGTACAAGGATAGCATTGGGCAGCTGGAGAATGATCTG AGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCT TACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTAC CTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCA TCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAG >In-frame_SLK_ENST00000335753_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_585nt ATGTCCTTCTTCAATTTCCGTAAGATCTTCAAGTTGGGGAGCGAGAAGAAGAAGAAGCAGTACGAACACGTGAAGAGGGACCTGAACCCC GAAGACTTTTGGGAGATTATAGGAGAACTGGGCGACGGAGCCTTTGGGAAAGTGTACAAGGATAGCATTGGGCAGCTGGAGAATGATCTG AGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCT TACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTAC CTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCA TCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLK_ENST00000369755_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_2812nt GCGGCGGCGGCGCCCCAGACCCGAGGGGACGCGCGGGCCTTGCGCCGCGGGAGCGGACGGCGGCGGAGGAGACCCTAGGCTCGCGGCCCG AGGCGGGAGGGCTCGGCTTCTCGACTGCCCGCCTCCGAGGCCGCCGGCCGCTTCTCTCTCCCAGAGTGGCCGCCGCCCCTGGAGACTCGC CGTGACACGGGCCTAAGCCGCCGCCGCGGGAGTCCTGACCGCTCGGACCCGTCGGATCAGGCCGGGTGGGAGCGAGCTTGCGGGCAGGTG CCGCTCCCGGAGGGTGGGCCGGAGGCGAGGCGCCCACCGCGCGGCTCGCGGGCCGGGCTCGGCGGAGGGGCCGCTCGCGCAGCACCCCCA CCGCGGGCCGGAGCCCGGGTCGCCGCCCCGCCTTCTCCCGGGACCGCCCGGCCGGAGCTGCGGGGGCCGAGGGACGCCGCGCCCGCCGCC GCCAGCCGGGCTCGCGCGGGAGAGCAGGGAAGAGAAACTTTGCCTTTTATTGTTTTTAGTCCTTAAGTGCAAGGAACTCTGTGTTGGGAG GAAAAATGTCCTTCTTCAATTTCCGTAAGATCTTCAAGTTGGGGAGCGAGAAGAAGAAGAAGCAGTACGAACACGTGAAGAGGGACCTGA ACCCCGAAGACTTTTGGGAGATTATAGGAGAACTGGGCGACGGAGCCTTTGGGAAAGTGTACAAGGATAGCATTGGGCAGCTGGAGAATG ATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAG CAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAA GTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGG AGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAA CCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGA TATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAG TATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAG AATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGAT CATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACA TAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGA CACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATT TTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAA TTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAA AATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCAC CTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTA TGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCA CGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTG TCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTT CTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGA AGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCC AGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTT CCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAAC TTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGT >In-frame_SLK_ENST00000335753_chr10_105727653_+_INA_ENST00000369849_chr10_105046792_+_2812nt GCGGCGGCGGCGCCCCAGACCCGAGGGGACGCGCGGGCCTTGCGCCGCGGGAGCGGACGGCGGCGGAGGAGACCCTAGGCTCGCGGCCCG AGGCGGGAGGGCTCGGCTTCTCGACTGCCCGCCTCCGAGGCCGCCGGCCGCTTCTCTCTCCCAGAGTGGCCGCCGCCCCTGGAGACTCGC CGTGACACGGGCCTAAGCCGCCGCCGCGGGAGTCCTGACCGCTCGGACCCGTCGGATCAGGCCGGGTGGGAGCGAGCTTGCGGGCAGGTG CCGCTCCCGGAGGGTGGGCCGGAGGCGAGGCGCCCACCGCGCGGCTCGCGGGCCGGGCTCGGCGGAGGGGCCGCTCGCGCAGCACCCCCA CCGCGGGCCGGAGCCCGGGTCGCCGCCCCGCCTTCTCCCGGGACCGCCCGGCCGGAGCTGCGGGGGCCGAGGGACGCCGCGCCCGCCGCC GCCAGCCGGGCTCGCGCGGGAGAGCAGGGAAGAGAAACTTTGCCTTTTATTGTTTTTAGTCCTTAAGTGCAAGGAACTCTGTGTTGGGAG GAAAAATGTCCTTCTTCAATTTCCGTAAGATCTTCAAGTTGGGGAGCGAGAAGAAGAAGAAGCAGTACGAACACGTGAAGAGGGACCTGA ACCCCGAAGACTTTTGGGAGATTATAGGAGAACTGGGCGACGGAGCCTTTGGGAAAGTGTACAAGGATAGCATTGGGCAGCTGGAGAATG ATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAG CAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAA GTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGG AGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAA CCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGA TATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAG TATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAG AATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGAT CATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACA TAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGA CACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATT TTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAA TTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAA AATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCAC CTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTA TGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCA CGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTG TCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTT CTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGA AGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCC AGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTT CCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAAC TTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGT 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FusionGenePPI for SLK_INA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLK | PDZK1, KEAP1, CLSTN1, NONO, RABL2A, HGS, HGH1, TTC4, MRPL43, ARHGEF1, NSFL1C, PPP1R2, RBM8A, SFN, MAP4, PITHD1, YWHAB, YWHAZ, NTRK1, MED4, CDH1, GTF2E2, FGB, SNRNP27 | INA | SQSTM1, ARRB1, SIRT7, PPP1CA, PAN2, PARK2, STAU1, CUL7, OBSL1, CCDC183, CENPP, ERGIC1, PRMT8, MAB21L2, CTBP1, NTRK1, CNTROB, ODF2, GAN, NEFM, VIM, SYNC, CCDC120, RSPRY1, NEFH, GFAP, MIPEP, CAPN1, VSIG8, VWA3B, BFSP2, BMP1, GJB7, BAZ2B, KLHL36, TIAL1, DLST, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLK_INA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLK_INA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLK | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | INA | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | INA | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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