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Fusion gene ID: 34693 |
FusionGeneSummary for SLIT3_PPARGC1B |
Fusion gene summary |
Fusion gene information | Fusion gene name: SLIT3_PPARGC1B | Fusion gene ID: 34693 | Hgene | Tgene | Gene symbol | SLIT3 | PPARGC1B | Gene ID | 6586 | 133522 |
Gene name | slit guidance ligand 3 | PPARG coactivator 1 beta | |
Synonyms | MEGF5|SLIL2|SLIT1|Slit-3|slit2 | ERRL1|PERC|PGC-1(beta)|PGC1B | |
Cytomap | 5q34-q35.1 | 5q32 | |
Type of gene | protein-coding | protein-coding | |
Description | slit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3 | peroxisome proliferator-activated receptor gamma coactivator 1-betaPGC-1-related estrogen receptor alpha coactivatorPPAR-gamma coactivator 1-betaPPARGC-1-betaPPARgamma coactivator 1 betaperoxisome proliferator-activated receptor gamma, coactivator 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O75094 | Q86YN6 | |
Ensembl transtripts involved in fusion gene | ENST00000519560, ENST00000332966, ENST00000404867, ENST00000521130, | ENST00000360453, ENST00000394320, ENST00000461780, ENST00000309241, ENST00000403750, | |
Fusion gene scores | * DoF score | 7 X 5 X 4=140 | 5 X 5 X 4=100 |
# samples | 7 | 5 | |
** MAII score | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLIT3 [Title/Abstract] AND PPARGC1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLIT3 | GO:0007411 | axon guidance | 11748139 |
Hgene | SLIT3 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | 11748139 |
Hgene | SLIT3 | GO:0048846 | axon extension involved in axon guidance | 16840550 |
Hgene | SLIT3 | GO:0050919 | negative chemotaxis | 11748139 |
Tgene | PPARGC1B | GO:0006355 | regulation of transcription, DNA-templated | 23836911 |
Tgene | PPARGC1B | GO:0030520 | intracellular estrogen receptor signaling pathway | 11854298 |
Tgene | PPARGC1B | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11854298 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-3B-A9HS-01A | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000519560 | ENST00000360453 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
Frame-shift | ENST00000519560 | ENST00000394320 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000519560 | ENST00000461780 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000519560 | ENST00000309241 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000519560 | ENST00000403750 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
In-frame | ENST00000332966 | ENST00000360453 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
Frame-shift | ENST00000332966 | ENST00000394320 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000332966 | ENST00000461780 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000332966 | ENST00000309241 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000332966 | ENST00000403750 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
In-frame | ENST00000404867 | ENST00000360453 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
Frame-shift | ENST00000404867 | ENST00000394320 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000404867 | ENST00000461780 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000404867 | ENST00000309241 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5CDS-intron | ENST00000404867 | ENST00000403750 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5UTR-3CDS | ENST00000521130 | ENST00000360453 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5UTR-3CDS | ENST00000521130 | ENST00000394320 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5UTR-intron | ENST00000521130 | ENST00000461780 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5UTR-intron | ENST00000521130 | ENST00000309241 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
5UTR-intron | ENST00000521130 | ENST00000403750 | SLIT3 | chr5 | 168671709 | - | PPARGC1B | chr5 | 149225323 | + |
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FusionProtFeatures for SLIT3_PPARGC1B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SLIT3 | PPARGC1B |
May act as molecular guidance cue in cellular migration,and function may be mediated by interaction with roundabouthomolog receptors. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 34_61 | 113 | 1473 | Domain | Note=LRRNT |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 34_61 | 113 | 1524 | Domain | Note=LRRNT |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 62_83 | 113 | 1473 | Repeat | Note=LRR 1 |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 86_107 | 113 | 1473 | Repeat | Note=LRR 2 |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 62_83 | 113 | 1524 | Repeat | Note=LRR 1 |
Hgene | SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 86_107 | 113 | 1524 | Repeat | Note=LRR 2 |
Tgene | >PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 902_976 | 899 | 985 | Domain | RRM |
Tgene | >PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 902_976 | 874 | 960 | Domain | RRM |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1034_1072 | 113 | 1473 | Domain | EGF-like 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1074_1110 | 113 | 1473 | Domain | EGF-like 5 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1119_1155 | 113 | 1473 | Domain | EGF-like 6 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1158_1332 | 113 | 1473 | Domain | Laminin G-like |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1340_1365 | 113 | 1473 | Domain | EGF-like 7 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1368_1403 | 113 | 1473 | Domain | EGF-like 8 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1408_1444 | 113 | 1473 | Domain | EGF-like 9 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 1449_1523 | 113 | 1473 | Domain | CTCK |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 215_265 | 113 | 1473 | Domain | Note=LRRCT 1 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 271_307 | 113 | 1473 | Domain | Note=LRRNT 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 437_487 | 113 | 1473 | Domain | Note=LRRCT 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 496_532 | 113 | 1473 | Domain | Note=LRRNT 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 663_713 | 113 | 1473 | Domain | Note=LRRCT 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 716_752 | 113 | 1473 | Domain | Note=LRRNT 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 857_907 | 113 | 1473 | Domain | Note=LRRCT 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 918_953 | 113 | 1473 | Domain | EGF-like 1 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 955_994 | 113 | 1473 | Domain | EGF-like 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 996_1032 | 113 | 1473 | Domain | EGF-like 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1034_1072 | 113 | 1524 | Domain | EGF-like 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1074_1110 | 113 | 1524 | Domain | EGF-like 5 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1119_1155 | 113 | 1524 | Domain | EGF-like 6 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1158_1332 | 113 | 1524 | Domain | Laminin G-like |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1340_1365 | 113 | 1524 | Domain | EGF-like 7 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1368_1403 | 113 | 1524 | Domain | EGF-like 8 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1408_1444 | 113 | 1524 | Domain | EGF-like 9 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 1449_1523 | 113 | 1524 | Domain | CTCK |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 215_265 | 113 | 1524 | Domain | Note=LRRCT 1 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 271_307 | 113 | 1524 | Domain | Note=LRRNT 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 437_487 | 113 | 1524 | Domain | Note=LRRCT 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 496_532 | 113 | 1524 | Domain | Note=LRRNT 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 663_713 | 113 | 1524 | Domain | Note=LRRCT 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 716_752 | 113 | 1524 | Domain | Note=LRRNT 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 857_907 | 113 | 1524 | Domain | Note=LRRCT 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 918_953 | 113 | 1524 | Domain | EGF-like 1 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 955_994 | 113 | 1524 | Domain | EGF-like 2 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 996_1032 | 113 | 1524 | Domain | EGF-like 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 110_131 | 113 | 1473 | Repeat | Note=LRR 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 134_155 | 113 | 1473 | Repeat | Note=LRR 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 158_179 | 113 | 1473 | Repeat | Note=LRR 5 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 182_203 | 113 | 1473 | Repeat | Note=LRR 6 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 308_329 | 113 | 1473 | Repeat | Note=LRR 7 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 332_353 | 113 | 1473 | Repeat | Note=LRR 8 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 356_377 | 113 | 1473 | Repeat | Note=LRR 9 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 380_401 | 113 | 1473 | Repeat | Note=LRR 10 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 404_425 | 113 | 1473 | Repeat | Note=LRR 11 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 533_554 | 113 | 1473 | Repeat | Note=LRR 12 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 558_579 | 113 | 1473 | Repeat | Note=LRR 13 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 582_603 | 113 | 1473 | Repeat | Note=LRR 14 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 606_627 | 113 | 1473 | Repeat | Note=LRR 15 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 630_651 | 113 | 1473 | Repeat | Note=LRR 16 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 753_775 | 113 | 1473 | Repeat | Note=LRR 17 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 776_797 | 113 | 1473 | Repeat | Note=LRR 18 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 800_821 | 113 | 1473 | Repeat | Note=LRR 19 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000404867 | - | 3 | 36 | 824_845 | 113 | 1473 | Repeat | Note=LRR 20 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 110_131 | 113 | 1524 | Repeat | Note=LRR 3 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 134_155 | 113 | 1524 | Repeat | Note=LRR 4 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 158_179 | 113 | 1524 | Repeat | Note=LRR 5 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 182_203 | 113 | 1524 | Repeat | Note=LRR 6 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 308_329 | 113 | 1524 | Repeat | Note=LRR 7 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 332_353 | 113 | 1524 | Repeat | Note=LRR 8 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 356_377 | 113 | 1524 | Repeat | Note=LRR 9 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 380_401 | 113 | 1524 | Repeat | Note=LRR 10 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 404_425 | 113 | 1524 | Repeat | Note=LRR 11 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 533_554 | 113 | 1524 | Repeat | Note=LRR 12 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 558_579 | 113 | 1524 | Repeat | Note=LRR 13 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 582_603 | 113 | 1524 | Repeat | Note=LRR 14 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 606_627 | 113 | 1524 | Repeat | Note=LRR 15 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 630_651 | 113 | 1524 | Repeat | Note=LRR 16 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 753_775 | 113 | 1524 | Repeat | Note=LRR 17 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 776_797 | 113 | 1524 | Repeat | Note=LRR 18 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 800_821 | 113 | 1524 | Repeat | Note=LRR 19 |
Hgene | >SLIT3 | chr5:168671709 | chr5:149225323 | ENST00000519560 | - | 3 | 36 | 824_845 | 113 | 1524 | Repeat | Note=LRR 20 |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 430_450 | 938 | 1024 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 772_823 | 938 | 1024 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 430_450 | 899 | 985 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 772_823 | 899 | 985 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 430_450 | 938 | 1018 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 772_823 | 938 | 1018 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 430_450 | 874 | 960 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 772_823 | 874 | 960 | Compositional bias | Note=Glu-rich |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 902_976 | 938 | 1024 | Domain | RRM |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 902_976 | 938 | 1018 | Domain | RRM |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 156_160 | 938 | 1024 | Motif | Note=LXXLL motif 1 |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 691_694 | 938 | 1024 | Motif | Note=HCFC1-binding-motif (HBM) |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 156_160 | 899 | 985 | Motif | Note=LXXLL motif 1 |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 691_694 | 899 | 985 | Motif | Note=HCFC1-binding-motif (HBM) |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 156_160 | 938 | 1018 | Motif | Note=LXXLL motif 1 |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 691_694 | 938 | 1018 | Motif | Note=HCFC1-binding-motif (HBM) |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 156_160 | 874 | 960 | Motif | Note=LXXLL motif 1 |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 691_694 | 874 | 960 | Motif | Note=HCFC1-binding-motif (HBM) |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000309241 | + | 9 | 12 | 1_91 | 938 | 1024 | Region | Note=Abolishes DNA transcriptional activity when missing |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000360453 | + | 8 | 11 | 1_91 | 899 | 985 | Region | Note=Abolishes DNA transcriptional activity when missing |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000394320 | + | 9 | 11 | 1_91 | 938 | 1018 | Region | Note=Abolishes DNA transcriptional activity when missing |
Tgene | PPARGC1B | chr5:168671709 | chr5:149225323 | ENST00000403750 | + | 8 | 11 | 1_91 | 874 | 960 | Region | Note=Abolishes DNA transcriptional activity when missing |
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FusionGeneSequence for SLIT3_PPARGC1B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SLIT3_ENST00000519560_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_199aa MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL HLEDNQVSVIERGAFQDLKQLERLGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSK >In-frame_SLIT3_ENST00000332966_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_199aa MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL HLEDNQVSVIERGAFQDLKQLERLGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSK >In-frame_SLIT3_ENST00000404867_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_199aa MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL HLEDNQVSVIERGAFQDLKQLERLGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SLIT3_ENST00000519560_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_597nt ATGGCCCCCGGGTGGGCAGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCA GCCGTCGCCTGCCCCACCAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCC CGCAACGCTGAGCGCCTTGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTG CATCTGGAAGACAACCAGGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTC ATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGC TACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAG >In-frame_SLIT3_ENST00000332966_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_597nt ATGGCCCCCGGGTGGGCAGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCA GCCGTCGCCTGCCCCACCAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCC CGCAACGCTGAGCGCCTTGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTG CATCTGGAAGACAACCAGGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTC ATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGC TACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAG >In-frame_SLIT3_ENST00000404867_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_597nt ATGGCCCCCGGGTGGGCAGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCA GCCGTCGCCTGCCCCACCAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCC CGCAACGCTGAGCGCCTTGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTG CATCTGGAAGACAACCAGGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTC ATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGC TACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SLIT3_ENST00000519560_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_1021nt GAGAGCGAGCGCCGGCCAGCTCACCCGGCCGCCCCGTGCCCCAGCCGCAGCCGCCGCGCTCCCCAGCCCAGCCCCAAGCCGGACCTCCCC GGGCGCCACGCCCCATTGCGCTCGCCCCAGGTCCCCAACCCGGCCCGCGGGCCAGCGGGGCCAGGGGGCGCTCCGCACCTGGGCACTCCC AGCGATGCGCAGCGGGGCAGCGCCGGCCCCGCCGATGGAGCTGCTGTTGCTGCCGCCGCCGCCGCCCGGAGCGCCCCGCTCCGCCCGCGC CCCGTGCGCCTGAGCACCGAGCTCGCCCCTCCTCCGCGCTAACTCCGCCGCCCGCTCCCCAGGCCGCCCGCGCTCCCCGCGCGCCTCCTC GGGCTCCACGCGTCTTGCCCCGCAGAGGCAGCCTCCTCCAGGAGCGGGGCCCTGCACACCATGGCCCCCGGGTGGGCAGGGGTCGGCGCC GCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCAGCCGTCGCCTGCCCCACCAAGTGTACCTGC TCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCCCGCAACGCTGAGCGCCTTGACCTGGACAGA AATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTGCATCTGGAAGACAACCAGGTCAGCGTCATC GAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCC CTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCACTTCTGCTGGCCC AGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTTTGACAGCTTACTG >In-frame_SLIT3_ENST00000332966_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_674nt CGCGCGCCTCCTCGGGCTCCACGCGTCTTGCCCCGCAGAGGCAGCCTCCTCCAGGAGCGGGGCCCTGCACACCATGGCCCCCGGGTGGGC AGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCAGCCGTCGCCTGCCCCAC CAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCCCGCAACGCTGAGCGCCT TGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTGCATCTGGAAGACAACCA GGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTC TGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCA CTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTT >In-frame_SLIT3_ENST00000404867_chr5_168671709_-_PPARGC1B_ENST00000360453_chr5_149225323_+_601nt ATGGCCCCCGGGTGGGCAGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCA GCCGTCGCCTGCCCCACCAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCC CGCAACGCTGAGCGCCTTGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTG CATCTGGAAGACAACCAGGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTC ATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGC TACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAG |
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FusionGenePPI for SLIT3_PPARGC1B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLIT3 | CAPN1, OTUB1 | PPARGC1B | ESR1, HNF4A, THRB, PPARA, ZNF200, ZNF212, ZFP64, ZNF513, ZBTB9, FOXA2, SRC, PIAS1, NR1H2, PNKD, SYVN1, PPARG, DNAJC10, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLIT3_PPARGC1B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLIT3_PPARGC1B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLIT3 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | SLIT3 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | SLIT3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | SLIT3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | PPARGC1B | C0020473 | Hyperlipidemia | 1 | CTD_human |
Tgene | PPARGC1B | C1458155 | Mammary Neoplasms | 1 | CTD_human |