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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34692

FusionGeneSummary for SLIT3_MAGED2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT3_MAGED2
Fusion gene ID: 34692
HgeneTgene
Gene symbol

SLIT3

MAGED2

Gene ID

6586

10916

Gene nameslit guidance ligand 3MAGE family member D2
SynonymsMEGF5|SLIL2|SLIT1|Slit-3|slit211B6|BARTS5|BCG-1|BCG1|HCA10|MAGE-D2
Cytomap

5q34-q35.1

Xp11.21

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3melanoma-associated antigen D2MAGE-D2 antigenbreast cancer-associated gene 1 proteinhepatocellular carcinoma-associated protein JCL-1melanoma antigen family D, 2melanoma antigen family D2
Modification date2018052220180519
UniProtAcc

O75094

Q9UNF1

Ensembl transtripts involved in fusion geneENST00000519560, ENST00000332966, 
ENST00000404867, ENST00000521130, 
ENST00000375068, ENST00000375053, 
ENST00000347546, ENST00000375062, 
ENST00000218439, ENST00000375058, 
ENST00000375060, ENST00000396224, 
ENST00000497484, 
Fusion gene scores* DoF score7 X 5 X 4=1403 X 3 X 1=9
# samples 74
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLIT3 [Title/Abstract] AND MAGED2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT3

GO:0007411

axon guidance

11748139

HgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT3

GO:0050919

negative chemotaxis

11748139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC023515SLIT3chr5

168198322

-MAGED2chrX

54834834

+
ChiTaRS3.1AF320070SLIT3chr5

168198322

-MAGED2chrX

54834834

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000519560ENST00000375068SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000519560ENST00000375053SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000519560ENST00000347546SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000519560ENST00000375062SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000519560ENST00000218439SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000519560ENST00000375058SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000519560ENST00000375060SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000519560ENST00000396224SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000519560ENST00000497484SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000375068SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000375053SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000347546SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000375062SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000332966ENST00000218439SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000332966ENST00000375058SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000332966ENST00000375060SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000396224SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000332966ENST00000497484SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000375068SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000375053SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000347546SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000375062SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000404867ENST00000218439SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000404867ENST00000375058SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000404867ENST00000375060SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000396224SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000404867ENST00000497484SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000375068SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000375053SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000347546SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000375062SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000521130ENST00000218439SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000521130ENST00000375058SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-5UTRENST00000521130ENST00000375060SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000396224SLIT3chr5

168198322

-MAGED2chrX

54834834

+
intron-intronENST00000521130ENST00000497484SLIT3chr5

168198322

-MAGED2chrX

54834834

+

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FusionProtFeatures for SLIT3_MAGED2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLIT3

O75094

MAGED2

Q9UNF1

May act as molecular guidance cue in cellular migration,and function may be mediated by interaction with roundabouthomolog receptors. Regulates the expression, localization to the plasmamembrane and function of the sodium chloride cotransportersSLC12A1 and SLC12A3, two key components of salt reabsorption inthe distal renal tubule. {ECO:0000269|PubMed:27120771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLIT3_MAGED2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLIT3_MAGED2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLIT3_MAGED2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLIT3_MAGED2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLIT3C0019284Diaphragmatic Hernia1CTD_human
HgeneSLIT3C0036341Schizophrenia1PSYGENET
HgeneSLIT3C0041696Unipolar Depression1PSYGENET
HgeneSLIT3C1269683Major Depressive Disorder1PSYGENET