FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34691

FusionGeneSummary for SLIT3_KCNMB4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT3_KCNMB4
Fusion gene ID: 34691
HgeneTgene
Gene symbol

SLIT3

KCNMB4

Gene ID

6586

27345

Gene nameslit guidance ligand 3potassium calcium-activated channel subfamily M regulatory beta subunit 4
SynonymsMEGF5|SLIL2|SLIT1|Slit-3|slit2-
Cytomap

5q34-q35.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3calcium-activated potassium channel subunit beta-4BK channel beta subunit 4BK channel subunit beta-4BKbeta4MaxiK channel beta-subunit 4big potassium channel beta subunit 4calcium-activated potassium channel, subfamily M subunit beta-4charybdotoxin
Modification date2018052220180523
UniProtAcc

O75094

Q86W47

Ensembl transtripts involved in fusion geneENST00000519560, ENST00000332966, 
ENST00000404867, ENST00000521130, 
ENST00000258111, 
Fusion gene scores* DoF score7 X 5 X 4=14010 X 4 X 6=240
# samples 710
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLIT3 [Title/Abstract] AND KCNMB4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT3

GO:0007411

axon guidance

11748139

HgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT3

GO:0050919

negative chemotaxis

11748139

TgeneKCNMB4

GO:0001508

action potential

10692449

TgeneKCNMB4

GO:0005513

detection of calcium ion

10692449

TgeneKCNMB4

GO:0006813

potassium ion transport

10692449

TgeneKCNMB4

GO:0019228

neuronal action potential

10692449


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A2QS-01ASLIT3chr5

168671709

-KCNMB4chr12

70792509

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000519560ENST00000258111SLIT3chr5

168671709

-KCNMB4chr12

70792509

+
5CDS-intronENST00000332966ENST00000258111SLIT3chr5

168671709

-KCNMB4chr12

70792509

+
5CDS-intronENST00000404867ENST00000258111SLIT3chr5

168671709

-KCNMB4chr12

70792509

+
5UTR-intronENST00000521130ENST00000258111SLIT3chr5

168671709

-KCNMB4chr12

70792509

+

Top

FusionProtFeatures for SLIT3_KCNMB4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLIT3

O75094

KCNMB4

Q86W47

May act as molecular guidance cue in cellular migration,and function may be mediated by interaction with roundabouthomolog receptors. Regulatory subunit of the calcium activated potassiumKCNMA1 (maxiK) channel. Modulates the calcium sensitivity andgating kinetics of KCNMA1, thereby contributing to KCNMA1 channeldiversity. Decreases the gating kinetics and calcium sensitivityof the KCNMA1 channel, but with fast deactivation kinetics. Maydecrease KCNMA1 channel openings at low calcium concentrations butincreases channel openings at high calcium concentrations. MakesKCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxinconcentrations. {ECO:0000269|PubMed:10692449,ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLIT3_KCNMB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLIT3_KCNMB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLIT3CAPN1, OTUB1KCNMB4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLIT3_KCNMB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKCNMB4Q86W47DB01110MiconazoleCalcium-activated potassium channel subunit beta-4small moleculeapproved|investigational|vet_approved

Top

RelatedDiseases for SLIT3_KCNMB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLIT3C0019284Diaphragmatic Hernia1CTD_human
HgeneSLIT3C0036341Schizophrenia1PSYGENET
HgeneSLIT3C0041696Unipolar Depression1PSYGENET
HgeneSLIT3C1269683Major Depressive Disorder1PSYGENET