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Fusion gene ID: 34684 |
FusionGeneSummary for SLIT1_FAM208B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLIT1_FAM208B | Fusion gene ID: 34684 | Hgene | Tgene | Gene symbol | SLIT1 | FAM208B | Gene ID | 6586 | 54906 |
| Gene name | slit guidance ligand 3 | family with sequence similarity 208 member B | |
| Synonyms | MEGF5|SLIL2|SLIT1|Slit-3|slit2 | C10orf18|bA318E3.2 | |
| Cytomap | 5q34-q35.1 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | slit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3 | protein FAM208B | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | O75093 | Q5VWN6 | |
| Ensembl transtripts involved in fusion gene | ENST00000266058, ENST00000371070, ENST00000371041, ENST00000456008, | ENST00000328090, ENST00000463468, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 2 X 3 X 1=6 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: SLIT1 [Title/Abstract] AND FAM208B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLIT1 | GO:0007411 | axon guidance | 11748139 |
| Hgene | SLIT1 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | 11748139 |
| Hgene | SLIT1 | GO:0048846 | axon extension involved in axon guidance | 16840550 |
| Hgene | SLIT1 | GO:0050919 | negative chemotaxis | 11748139 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM676949 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000266058 | ENST00000328090 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-intron | ENST00000266058 | ENST00000463468 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-3CDS | ENST00000371070 | ENST00000328090 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-intron | ENST00000371070 | ENST00000463468 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-3CDS | ENST00000371041 | ENST00000328090 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-intron | ENST00000371041 | ENST00000463468 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-3CDS | ENST00000456008 | ENST00000328090 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
| intron-intron | ENST00000456008 | ENST00000463468 | SLIT1 | chr10 | 98758125 | + | FAM208B | chr10 | 5789898 | - |
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FusionProtFeatures for SLIT1_FAM208B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLIT1 | FAM208B |
| Thought to act as molecular guidance cue in cellularmigration, and function appears to be mediated by interaction withroundabout homolog receptors. During neural development involvedin axonal navigation at the ventral midline of the neural tube andprojection of axons to different regions (By similarity). SLIT1and SLIT2 together seem to be essential for midline guidance inthe forebrain by acting as repulsive signal preventinginappropriate midline crossing by axons projecting from theolfactory bulb. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLIT1_FAM208B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLIT1_FAM208B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLIT1_FAM208B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLIT1_FAM208B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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