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Fusion gene ID: 34623 |
FusionGeneSummary for SLC7A6_TANGO6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC7A6_TANGO6 | Fusion gene ID: 34623 | Hgene | Tgene | Gene symbol | SLC7A6 | TANGO6 | Gene ID | 9057 | 79613 |
| Gene name | solute carrier family 7 member 6 | transport and golgi organization 6 homolog | |
| Synonyms | LAT-2|LAT3|y+LAT-2 | TMCO7 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Y+L amino acid transporter 2amino acid permeasecationic amino acid transporter, y+ systemsolute carrier family 7 (amino acid transporter light chain, y+L system), member 6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6y | transport and Golgi organization protein 6 homologtransmembrane and coiled-coil domain-containing protein 7transmembrane and coiled-coil domains 7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q92536 | Q9C0B7 | |
| Ensembl transtripts involved in fusion gene | ENST00000219343, ENST00000566454, | ENST00000261778, ENST00000561931, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 5 X 4 X 6=120 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC7A6 [Title/Abstract] AND TANGO6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-CD-A487-01A | SLC7A6 | chr16 | 68309152 | + | TANGO6 | chr16 | 69007931 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000219343 | ENST00000261778 | SLC7A6 | chr16 | 68309152 | + | TANGO6 | chr16 | 69007931 | + |
| 5CDS-intron | ENST00000219343 | ENST00000561931 | SLC7A6 | chr16 | 68309152 | + | TANGO6 | chr16 | 69007931 | + |
| In-frame | ENST00000566454 | ENST00000261778 | SLC7A6 | chr16 | 68309152 | + | TANGO6 | chr16 | 69007931 | + |
| 5CDS-intron | ENST00000566454 | ENST00000561931 | SLC7A6 | chr16 | 68309152 | + | TANGO6 | chr16 | 69007931 | + |
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FusionProtFeatures for SLC7A6_TANGO6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC7A6 | TANGO6 |
| Involved in the sodium-independent uptake of dibasicamino acids and sodium-dependent uptake of some neutral aminoacids. Requires coexpression with SLC3A2/4F2hc to mediate theuptake of arginine, leucine and glutamine. Also acts as anarginine/glutamine exchanger, following an antiport mechanism foramino acid transport, influencing arginine release in exchange forextracellular amino acids. Plays a role in nitric oxide synthesisin human umbilical vein endothelial cells (HUVECs) via transportof L-arginine. Involved in the transport of L-arginine inmonocytes. Reduces uptake of ornithine in retinal pigmentepithelial (RPE) cells. {ECO:0000269|PubMed:10903140,ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368,ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:16785209,ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401,ECO:0000269|PubMed:9829974}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 100_114 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 136_167 | 174 | 516 | Topological domain | Extracellular |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 1_44 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 66_78 | 174 | 516 | Topological domain | Extracellular |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 100_114 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 136_167 | 174 | 516 | Topological domain | Extracellular |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 1_44 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 66_78 | 174 | 516 | Topological domain | Extracellular |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 115_135 | 174 | 516 | Transmembrane | Helical |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 45_65 | 174 | 516 | Transmembrane | Helical |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 79_99 | 174 | 516 | Transmembrane | Helical |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 115_135 | 174 | 516 | Transmembrane | Helical |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 45_65 | 174 | 516 | Transmembrane | Helical |
| Hgene | SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 79_99 | 174 | 516 | Transmembrane | Helical |
| Tgene | >TANGO6 | chr16:68309152 | chr16:69007931 | ENST00000261778 | + | 13 | 18 | 952_988 | 900 | 1095 | Repeat | Note=HEAT 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 189_194 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 216_235 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 257_266 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 288_311 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 333_363 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 385_385 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 407_425 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 447_451 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 473_515 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 189_194 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 216_235 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 257_266 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 288_311 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 333_363 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 385_385 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 407_425 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 447_451 | 174 | 516 | Topological domain | Extracellular |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 473_515 | 174 | 516 | Topological domain | Cytoplasmic |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 168_188 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 195_215 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 236_256 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 267_287 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 312_332 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 364_384 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 386_406 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 426_446 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000219343 | + | 3 | 11 | 452_472 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 168_188 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 195_215 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 236_256 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 267_287 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 312_332 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 364_384 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 386_406 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 426_446 | 174 | 516 | Transmembrane | Helical |
| Hgene | >SLC7A6 | chr16:68309152 | chr16:69007931 | ENST00000566454 | + | 4 | 12 | 452_472 | 174 | 516 | Transmembrane | Helical |
| Tgene | TANGO6 | chr16:68309152 | chr16:69007931 | ENST00000261778 | + | 13 | 18 | 873_909 | 900 | 1095 | Repeat | Note=HEAT 1 |
| Tgene | TANGO6 | chr16:68309152 | chr16:69007931 | ENST00000261778 | + | 13 | 18 | 468_488 | 900 | 1095 | Transmembrane | Helical |
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FusionGeneSequence for SLC7A6_TANGO6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLC7A6_ENST00000219343_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_369aa MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLF SVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACIWVALLS DVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVV HEVTACLIAVAKTDGEVQVRRAAIHVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEPDDVAKLHAQLALEELDDIMKNFLFPPQKL >In-frame_SLC7A6_ENST00000566454_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_369aa MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLF SVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACIWVALLS DVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVV HEVTACLIAVAKTDGEVQVRRAAIHVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEPDDVAKLHAQLALEELDDIMKNFLFPPQKL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLC7A6_ENST00000219343_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_1107nt ATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGCCAGTCCCAGGTGGAAGAAGATGTCAGCTCG CCACCTCAAAGGTCCTCCGAAACTATGCAGCTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGC TCAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGTCACTGATTGTGTGGGCCATTGGTGGGCTCTTC TCTGTTGTGGGTGCCCTTTGTTATGCAGAGCTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGG GGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAGGCCATCATCGCCATCACCTTTGCCAACTAC ATCATCCAGCCGTCCTTCCCCAGCTGTGATCCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGGGTTGCCCTGCTGTCA GACGTCTATCCTGAGAAAATCTTGCCGGACTTGTTGGCTCAATATGACAGCAGCAAAGACAAGCACACACCAGAGACCAGAATGAAAGTC GGGGAAGTCCTTATGCGAATCGTCAGGGCATTAGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTG AGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTC CATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTG CTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAG CCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTG >In-frame_SLC7A6_ENST00000566454_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_1107nt ATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGCCAGTCCCAGGTGGAAGAAGATGTCAGCTCG CCACCTCAAAGGTCCTCCGAAACTATGCAGCTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGC TCAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGTCACTGATTGTGTGGGCCATTGGTGGGCTCTTC TCTGTTGTGGGTGCCCTTTGTTATGCAGAGCTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGG GGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAGGCCATCATCGCCATCACCTTTGCCAACTAC ATCATCCAGCCGTCCTTCCCCAGCTGTGATCCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGGGTTGCCCTGCTGTCA GACGTCTATCCTGAGAAAATCTTGCCGGACTTGTTGGCTCAATATGACAGCAGCAAAGACAAGCACACACCAGAGACCAGAATGAAAGTC GGGGAAGTCCTTATGCGAATCGTCAGGGCATTAGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTG AGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTC CATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTG CTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAG CCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLC7A6_ENST00000219343_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_2838nt CGGCGGCGGCGCGACCGAGCATCCTGGCGGCGCCGGGCCACTGGGAGAGTTTATGTGGCCGAGGCAGACAAGTGGAATTAGGCCTTGCTG CAGGGGACTTCATTTCCTTCTCAGTACTGGACCCATTTATGAGGAGGTGGCTTATGAAAGTGTGATGTTCGCGTATTTCTTGACAGGCCA CAGCAAACACAGGTGTGCAGGAACCGTTTGTCATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCA GCCAGTCCCAGGTGGAAGAAGATGTCAGCTCGCCACCTCAAAGGTCCTCCGAAACTATGCAGCTGAAGAAGGAGATCTCCCTGCTGAATG GGGTCAGCCTGGTGGTGGGCAACATGATCGGCTCAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGT CACTGATTGTGTGGGCCATTGGTGGGCTCTTCTCTGTTGTGGGTGCCCTTTGTTATGCAGAGCTGGGGACCACCATCACCAAGTCGGGAG CCAGCTACGCTTATATTCTAGAGGCCTTTGGGGGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTC AGGCCATCATCGCCATCACCTTTGCCAACTACATCATCCAGCCGTCCTTCCCCAGCTGTGATCCCCCATACCTGGCCTGCCGTCTCCTGG CTGCTGCTTGCATATGGGTTGCCCTGCTGTCAGACGTCTATCCTGAGAAAATCTTGCCGGACTTGTTGGCTCAATATGACAGCAGCAAAG ACAAGCACACACCAGAGACCAGAATGAAAGTCGGGGAAGTCCTTATGCGAATCGTCAGGGCATTAGGAGACATGGTCTCAAAGTACCGAG AACCTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCC AGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTAC GCAGAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCT ACCACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCA TGAAAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGGCAGGC AGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCGGGGTG GTTTTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTACAGTT AAGAGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTATATTT TAACATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTCTATAT TCTTTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAGATGCA GTTGGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAATCTGG TCCTCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGAGAAGA AGGGTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGAAAAGA ACCACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACTGAATG CAGGCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATTTCTTT ATATGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCTCTGTT GTCAACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATTTTATC ACGCTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATGGCTAT TTGCTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAAAGAGG CCATCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCATTCAG CTAGTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCTCCTTT >In-frame_SLC7A6_ENST00000566454_chr16_68309152_+_TANGO6_ENST00000261778_chr16_69007931_+_2895nt CGCCGGGCCACTGGGAGAGTTTATGTGGCCGAGGCAGACAAGTGGAATTAGGCCTTGCTGCAGGGGACTTCATTTCCTTCTCAGTACTGG ACCCATTTATGAGGAGGTGGCTTATGAAAGTGTGATGTTCGCGTATTTCTTGACAGGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCG ACTCCCTGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGGGGATTACAGGCCACAGCAAACACAGGTGTGCAGGAACCGTTTGTCA TGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGCCAGTCCCAGGTGGAAGAAGATGTCAGCTCGC CACCTCAAAGGTCCTCCGAAACTATGCAGCTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGCT CAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGTCACTGATTGTGTGGGCCATTGGTGGGCTCTTCT CTGTTGTGGGTGCCCTTTGTTATGCAGAGCTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGGG GCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAGGCCATCATCGCCATCACCTTTGCCAACTACA TCATCCAGCCGTCCTTCCCCAGCTGTGATCCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGGGTTGCCCTGCTGTCAG ACGTCTATCCTGAGAAAATCTTGCCGGACTTGTTGGCTCAATATGACAGCAGCAAAGACAAGCACACACCAGAGACCAGAATGAAAGTCG GGGAAGTCCTTATGCGAATCGTCAGGGCATTAGGAGACATGGTCTCAAAGTACCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTGA GAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCC ATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTGC TTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAGC CCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTGG AGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGGCAGGCAGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTT CCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCGGGGTGGTTTTATGGTGCAGGTCACTTGGGTCTTCAGGG TCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTACAGTTAAGAGAAGACAGTTACAGATCTCATTAATCTAC ATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTATATTTTAACATGACTGATGGAATTTCACTAATTGCCCA CTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTCTATATTCTTTCAGGCTGAGATTCTTCTTCAGGAAAATG AGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAGATGCAGTTGGAGGTGGGGAGGGGAAGGAAATAGTTATC AAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAATCTGGTCCTCTGGTGTCGAGATGGAAAACTGTGGAGTT GAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGAGAAGAAGGGTAAGCCCTGTATTTATCCTCCCAGGCCAT TCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGAAAAGAACCACGAGCATCCAGAGAGTTTACATCCTGCCT TCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACTGAATGCAGGCTGGAAAGAATGCATGCTGGTGGCCTAAT GCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATTTCTTTATATGTTTTGGCCGCTGCATTTTGATTGCAGCT AAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCTCTGTTGTCAACACCTTGATGAGGCCAACCCAGAGATGC TTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATTTTATCACGCTCTCTGGGGTGACTAGATCCACAGGAACC AAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATGGCTATTTGCTAGTTAACAACAGGATATTTCTCTCTGGC CAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAAAGAGGCCATCTTATGAACAGGATCACAAGTGAGCTTAG TGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCATTCAGCTAGTGTAGCTGGATTAATTTCTATTCTCCAAA TCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCTCCTTTGGGCCAGCTGGATGTACAATAAAAATGCTTGTT |
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FusionGenePPI for SLC7A6_TANGO6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC7A6 | MAS1, TRIM25 | TANGO6 | MACF1, UBE2S, CAPZA2, P4HA2, MTNR1B, ZNHIT2, RPAP3, RUVBL1, RUVBL2, URI1, WDR92 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC7A6_TANGO6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC7A6_TANGO6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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