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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34611

FusionGeneSummary for SLC7A2_ETS2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC7A2_ETS2
Fusion gene ID: 34611
HgeneTgene
Gene symbol

SLC7A2

ETS2

Gene ID

6542

2114

Gene namesolute carrier family 7 member 2ETS proto-oncogene 2, transcription factor
SynonymsATRC2|CAT2|HCAT2ETS2IT1
Cytomap

8p22

21q22.2

Type of geneprotein-codingprotein-coding
Descriptioncationic amino acid transporter 2low affinity cationic amino acid transporter 2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2protein C-ets-2oncogene ETS-2v-ets avian erythroblastosis virus E2 oncogene homolog 2v-ets avian erythroblastosis virus E26 oncogene homolog 2v-ets erythroblastosis virus E26 oncogene homolog 2
Modification date2018052320180523
UniProtAcc

P52569

P15036

Ensembl transtripts involved in fusion geneENST00000494857, ENST00000522656, 
ENST00000470360, ENST00000004531, 
ENST00000398090, 
ENST00000360214, 
ENST00000360938, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 1=9
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC7A2 [Title/Abstract] AND ETS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETS2

GO:0000122

negative regulation of transcription by RNA polymerase II

12637547

TgeneETS2

GO:0045893

positive regulation of transcription, DNA-templated

11909962


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF086382SLC7A2chr8

17395576

+ETS2chr21

40196451

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000494857ENST00000360214SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000494857ENST00000360938SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000522656ENST00000360214SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000522656ENST00000360938SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000470360ENST00000360214SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000470360ENST00000360938SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000004531ENST00000360214SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000004531ENST00000360938SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000398090ENST00000360214SLC7A2chr8

17395576

+ETS2chr21

40196451

-
intron-3UTRENST00000398090ENST00000360938SLC7A2chr8

17395576

+ETS2chr21

40196451

-

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FusionProtFeatures for SLC7A2_ETS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC7A2

P52569

ETS2

P15036

Functions as permease involved in the transport of thecationic amino acids (arginine, lysine and ornithine); theaffinity for its substrates differs between isoforms created byalternative splicing. Isoform 1 functions as permease thatmediates the transport of the cationic amino acids (arginine,lysine and ornithine), and it has much higher affinity forarginine than isoform 2. Isoform 2 functions as low-affinity, highcapacity permease involved in the transport of the cationic aminoacids (arginine, lysine and ornithine) (PubMed:9174363). May playa role in classical or alternative activation of macrophages viaits role in arginine transport. {ECO:0000250|UniProtKB:P18581,ECO:0000269|PubMed:9174363}. Transcription factor activating transcription. Bindsspecifically the DNA GGAA/T core motif (Ets-binding site or EBS)in gene promoters and stimulates transcription.{ECO:0000269|PubMed:11909962}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC7A2_ETS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC7A2_ETS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC7A2_ETS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC7A2P52569DB00123L-LysineCationic amino acid transporter 2small moleculeapproved|nutraceutical

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RelatedDiseases for SLC7A2_ETS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneETS2C0027746Nerve Degeneration1CTD_human
TgeneETS2C0162820Dermatitis, Allergic Contact1CTD_human
TgeneETS2C0376634Craniofacial Abnormalities1CTD_human
TgeneETS2C1458155Mammary Neoplasms1CTD_human