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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34605

FusionGeneSummary for SLC7A1_FOXO1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC7A1_FOXO1
Fusion gene ID: 34605
HgeneTgene
Gene symbol

SLC7A1

FOXO1

Gene ID

6541

2308

Gene namesolute carrier family 7 member 1forkhead box O1
SynonymsATRC1|CAT-1|ERR|HCAT1|REC1LFKH1|FKHR|FOXO1A
Cytomap

13q12.3

13q14.11

Type of geneprotein-codingprotein-coding
Descriptionhigh affinity cationic amino acid transporter 1CAT1amino acid transporter, cationic 1ecotropic retroviral leukemia receptor homologecotropic retroviral receptorecotropic retrovirus receptor homologsolute carrier family 7 (cationic amino acid transpoforkhead box protein O1forkhead box protein O1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma
Modification date2018052320180527
UniProtAcc

P30825

Q12778

Ensembl transtripts involved in fusion geneENST00000380752, ENST00000473577, 
ENST00000379561, ENST00000473775, 
Fusion gene scores* DoF score8 X 4 X 7=2248 X 6 X 4=192
# samples 812
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/192*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC7A1 [Title/Abstract] AND FOXO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOXO1

GO:0009267

cellular response to starvation

20543840

TgeneFOXO1

GO:0032873

negative regulation of stress-activated MAPK cascade

19696738

TgeneFOXO1

GO:0043066

negative regulation of apoptotic process

10871843

TgeneFOXO1

GO:0045893

positive regulation of transcription, DNA-templated

7862145|10871843|12228231

TgeneFOXO1

GO:0045944

positive regulation of transcription by RNA polymerase II

10871843|12228231

TgeneFOXO1

GO:0071455

cellular response to hyperoxia

20543840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-PC-A5DM-01ASLC7A1chr13

30127898

-FOXO1chr13

41134997

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000380752ENST00000379561SLC7A1chr13

30127898

-FOXO1chr13

41134997

-
5UTR-5UTRENST00000380752ENST00000473775SLC7A1chr13

30127898

-FOXO1chr13

41134997

-
intron-3CDSENST00000473577ENST00000379561SLC7A1chr13

30127898

-FOXO1chr13

41134997

-
intron-5UTRENST00000473577ENST00000473775SLC7A1chr13

30127898

-FOXO1chr13

41134997

-

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FusionProtFeatures for SLC7A1_FOXO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC7A1

P30825

FOXO1

Q12778

High-affinity, low capacity permease involved in thetransport of the cationic amino acids (arginine, lysine andornithine) in non-hepatic tissues. {ECO:0000269|PubMed:10485994}. Transcription factor that is the main target of insulinsignaling and regulates metabolic homeostasis in response tooxidative stress. Binds to the insulin response element (IRE) withconsensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator ofredox balance and osteoblast numbers and controls bone mass.Orchestrates the endocrine function of the skeleton in regulatingglucose metabolism. Acts synergistically with ATF4 to suppressosteocalcin/BGLAP activity, increasing glucose levels andtriggering glucose intolerance and insulin insensitivity. Alsosuppresses the transcriptional activity of RUNX2, an upstreamactivator of osteocalcin/BGLAP. In hepatocytes, promotesgluconeogenesis by acting together with PPARGC1A and CEBPA toactivate the expression of genes such as IGFBP1, G6PC and PCK1.Important regulator of cell death acting downstream of CDK1,PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediatesinsulin action on adipose tissue. Regulates the expression ofadipogenic genes such as PPARG during preadipocyte differentiationand, adipocyte size and adipose tissue-specific gene expression inresponse to excessive calorie intake. Regulates thetranscriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell deathinduction in response to starvation or oxidative stress in atranscription-independent manner. Mediates the function of MLIP incardiomyocytes hypertrophy and cardiac remodeling (By similarity).{ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0,ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231,ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677,ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179,ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC7A1_FOXO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC7A1_FOXO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC7A1ELAVL1, APP, BAG3, FATE1, TMEM17, SLC33A1, UBXN8, RAC3, BCL2L13, METTL7A, MTCH2, DGAT1, ZDHHC21, TMEM120B, TMEM11, STX4, LEMD2, AGPAT3, SLC35B2, TVP23C, MGAT5, AGPAT4, FKRP, FLVCR1, SLC39A1, SLC19A2, YIPF4, TSPAN15, STX12, MBOAT7, ELOVL5, FITM2, MAVS, C9orf91, GNPAT, CYB5R1, NDC1, CKAP4, ACP2, GHITM, SGPP1, PIGW, TMEM223, SYNGR2, KIAA1715, CMTM4, GPR89A, YIPF6, TMEM186, GPRC5C, GOLM1, SLC22A18, PRAF2, ZDHHC9, C19orf52, ELOVL4, NAT14, HS2ST1, PARL, LMNAFOXO1AR, SMAD3, SMAD4, CREBBP, YWHAG, YWHAZ, TSC2, ESR1, CEBPB, HOXA5, HNF4A, RFWD2, PARP1, HOXA11, LRPPRC, SKP2, PML, SIRT1, AKT1, SIRT2, ATG7, STUB1, NLK, MDM2, RARA, FSHR, IRF3, FHL2, EP300, MST1, YWHAQ, NCOA1, PIK3R3, TENC1, XPO1, CCNB1, CDKN1A, GSK3B, FOXO1, FOXO4, RECQL, FOXO3B, CUX1, DLX5, HOXD13, SATB1, SATB2, SMARCA4, SETD7, MORF4L2, SNX17, RB1, DNAJC9, FOXO6, PRKACA, CRY1, PITX1, SIRT7, ATM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC7A1_FOXO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC7A1P30825DB00123L-LysineHigh affinity cationic amino acid transporter 1small moleculeapproved|nutraceutical
HgeneSLC7A1P30825DB00125L-ArginineHigh affinity cationic amino acid transporter 1small moleculeapproved|nutraceutical

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RelatedDiseases for SLC7A1_FOXO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC7A1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC7A1C0033578Prostatic Neoplasms1CTD_human
TgeneFOXO1C0022578Keratoconus1CTD_human
TgeneFOXO1C0023467Leukemia, Myelocytic, Acute1CTD_human