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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34584

FusionGeneSummary for SLC5A2_SLC5A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC5A2_SLC5A2
Fusion gene ID: 34584
HgeneTgene
Gene symbol

SLC5A2

SLC5A2

Gene ID

6524

6524

Gene namesolute carrier family 5 member 2solute carrier family 5 member 2
SynonymsSGLT2SGLT2
Cytomap

16p11.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionsodium/glucose cotransporter 2Na(+)/glucose cotransporter 2low affinity sodium-glucose cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 2solute carrier family 5 (sodium/glucose transporter), member 2sodium/glucose cotransporter 2Na(+)/glucose cotransporter 2low affinity sodium-glucose cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 2solute carrier family 5 (sodium/glucose transporter), member 2
Modification date2018052320180523
UniProtAcc

P31639

P31639

Ensembl transtripts involved in fusion geneENST00000330498, ENST00000564197, 
ENST00000330498, ENST00000564197, 
Fusion gene scores* DoF score2 X 5 X 1=101 X 4 X 1=4
# samples 54
** MAII scorelog2(5/10*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/4*10)=3.32192809488736
Context

PubMed: SLC5A2 [Title/Abstract] AND SLC5A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T29710SLC5A2chr16

31501144

-SLC5A2chr16

31502114

-
ChiTaRS3.1BG913471SLC5A2chr16

31501070

+SLC5A2chr16

31500991

-
ChiTaRS3.1BQ367848SLC5A2chr16

31501674

+SLC5A2chr16

31873291

-
ChiTaRS3.1BI517676SLC5A2chr16

31500053

+SLC5A2chr16

31499745

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000330498ENST00000330498SLC5A2chr16

31501144

-SLC5A2chr16

31502114

-
intron-3UTRENST00000330498ENST00000564197SLC5A2chr16

31501144

-SLC5A2chr16

31502114

-
intron-intronENST00000564197ENST00000330498SLC5A2chr16

31501144

-SLC5A2chr16

31502114

-
intron-3UTRENST00000564197ENST00000564197SLC5A2chr16

31501144

-SLC5A2chr16

31502114

-
intron-intronENST00000330498ENST00000330498SLC5A2chr16

31501070

+SLC5A2chr16

31500991

-
intron-3UTRENST00000330498ENST00000564197SLC5A2chr16

31501070

+SLC5A2chr16

31500991

-
intron-intronENST00000564197ENST00000330498SLC5A2chr16

31501070

+SLC5A2chr16

31500991

-
intron-3UTRENST00000564197ENST00000564197SLC5A2chr16

31501070

+SLC5A2chr16

31500991

-
5CDS-intronENST00000330498ENST00000330498SLC5A2chr16

31501674

+SLC5A2chr16

31873291

-
5CDS-intronENST00000330498ENST00000564197SLC5A2chr16

31501674

+SLC5A2chr16

31873291

-
intron-intronENST00000564197ENST00000330498SLC5A2chr16

31501674

+SLC5A2chr16

31873291

-
intron-intronENST00000564197ENST00000564197SLC5A2chr16

31501674

+SLC5A2chr16

31873291

-
Frame-shiftENST00000330498ENST00000330498SLC5A2chr16

31500053

+SLC5A2chr16

31499745

-
5CDS-intronENST00000330498ENST00000564197SLC5A2chr16

31500053

+SLC5A2chr16

31499745

-
intron-3CDSENST00000564197ENST00000330498SLC5A2chr16

31500053

+SLC5A2chr16

31499745

-
intron-intronENST00000564197ENST00000564197SLC5A2chr16

31500053

+SLC5A2chr16

31499745

-

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FusionProtFeatures for SLC5A2_SLC5A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC5A2

P31639

SLC5A2

P31639

Sodium-dependent glucose transporter. Has a Na(+) toglucose coupling ratio of 1:1. Efficient substrate transport in mammalian kidney isprovided by the concerted action of a low affinity high capacityand a high affinity low capacity Na(+)/glucose cotransporterarranged in series along kidney proximal tubules. Sodium-dependent glucose transporter. Has a Na(+) toglucose coupling ratio of 1:1. Efficient substrate transport in mammalian kidney isprovided by the concerted action of a low affinity high capacityand a high affinity low capacity Na(+)/glucose cotransporterarranged in series along kidney proximal tubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC5A2_SLC5A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC5A2_SLC5A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC5A2_SLC5A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC5A2P31639DB06292DapagliflozinSodium/glucose cotransporter 2small moleculeapproved
HgeneSLC5A2P31639DB08907CanagliflozinSodium/glucose cotransporter 2small moleculeapproved
HgeneSLC5A2P31639DB09038EmpagliflozinSodium/glucose cotransporter 2small moleculeapproved
TgeneSLC5A2P31639DB06292DapagliflozinSodium/glucose cotransporter 2small moleculeapproved
TgeneSLC5A2P31639DB08907CanagliflozinSodium/glucose cotransporter 2small moleculeapproved
TgeneSLC5A2P31639DB09038EmpagliflozinSodium/glucose cotransporter 2small moleculeapproved

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RelatedDiseases for SLC5A2_SLC5A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC5A2C0017980Glycosuria, Renal1CTD_human;ORPHANET;UNIPROT
TgeneSLC5A2C0017980Glycosuria, Renal1CTD_human;ORPHANET;UNIPROT