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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34576

FusionGeneSummary for SLC50A1_SNHG1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC50A1_SNHG1
Fusion gene ID: 34576
HgeneTgene
Gene symbol

SLC50A1

SNHG1

Gene ID

55974

23642

Gene namesolute carrier family 50 member 1small nucleolar RNA host gene 1
SynonymsHsSWEET1|RAG1AP1|SCP|SWEET1|slvLINC00057|NCRNA00057|U22HG|UHG|lncRNA16
Cytomap

1q22

11q12.3

Type of geneprotein-codingncRNA
Descriptionsugar transporter SWEET1RAG1-activating protein 1RP11-540D14.5RZPDo834D038Dprobable sugar transporter RAG1AP1recombination activating gene 1 activating protein 1solute carrier family 50 (sugar efflux transporter), member 1solute carrier family 50 (U22 snoRNA hostlong intergenic non-protein coding RNA 57small nucleolar RNA host gene 1 (non-protein coding)
Modification date2018052320180519
UniProtAcc

Q9BRV3

Ensembl transtripts involved in fusion geneENST00000484157, ENST00000303343, 
ENST00000368404, ENST00000368401, 
ENST00000368405, 
ENST00000384756, 
ENST00000364799, ENST00000384693, 
ENST00000383926, ENST00000516331, 
ENST00000384706, ENST00000363981, 
ENST00000384147, ENST00000365607, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 7 X 5=245
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC50A1 [Title/Abstract] AND SNHG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW794624SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000484157ENST00000384756SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000364799SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000384693SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000383926SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000516331SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000384706SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000363981SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000384147SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000484157ENST00000365607SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000384756SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000364799SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000384693SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000383926SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000516331SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000384706SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000363981SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000384147SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000303343ENST00000365607SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000384756SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000364799SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000384693SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000383926SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000516331SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000384706SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000363981SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000384147SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368404ENST00000365607SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000384756SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000364799SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000384693SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000383926SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000516331SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000384706SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000363981SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000384147SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
5CDS-intronENST00000368401ENST00000365607SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000384756SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000364799SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000384693SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000383926SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000516331SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000384706SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000363981SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000384147SLC50A1chr1

155110106

+SNHG1chr11

62620013

+
intron-intronENST00000368405ENST00000365607SLC50A1chr1

155110106

+SNHG1chr11

62620013

+

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FusionProtFeatures for SLC50A1_SNHG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC50A1

Q9BRV3

SNHG1

Mediates sugar transport across membranes. May stimulateV(D)J recombination by the activation of RAG1.{ECO:0000269|PubMed:21107422}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC50A1_SNHG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC50A1_SNHG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC50A1_SNHG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC50A1_SNHG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource