FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3456

FusionGeneSummary for ATP6V0E1_OXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP6V0E1_OXR1
Fusion gene ID: 3456
HgeneTgene
Gene symbol

ATP6V0E1

OXR1

Gene ID

8992

55074

Gene nameATPase H+ transporting V0 subunit e1oxidation resistance 1
SynonymsATP6H|ATP6V0E|M9.2|Vma21|Vma21pNbla00307|TLDC3
Cytomap

5q35.1

8q23.1

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase subunit e 1ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1H(+)-transporting two-sector ATPase, subunit HV-ATPase 9.2 kDa membrane accessory proteinV-ATPase H subunitV-ATPase M9.2 subunitV-ATPase subunit e 1vacuolar ATP soxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307
Modification date2018052320180519
UniProtAcc

O15342

Q8N573

Ensembl transtripts involved in fusion geneENST00000519374, ENST00000519911, 
ENST00000265093, ENST00000517669, 
ENST00000445937, ENST00000531443, 
ENST00000517566, ENST00000452423, 
ENST00000442977, ENST00000521963, 
ENST00000312046, ENST00000449762, 
ENST00000297447, ENST00000521592, 
ENST00000497705, 
Fusion gene scores* DoF score6 X 6 X 3=10811 X 10 X 4=440
# samples 612
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP6V0E1 [Title/Abstract] AND OXR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX474197ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000519374ENST00000445937ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000531443ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000517566ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000452423ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000442977ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000521963ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000312046ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000449762ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000297447ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000521592ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519374ENST00000497705ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000445937ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000531443ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000517566ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000452423ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000442977ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000521963ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000312046ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000449762ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000297447ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000521592ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000519911ENST00000497705ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000445937ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000531443ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000517566ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000452423ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000442977ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000521963ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000312046ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000449762ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000297447ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000521592ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000265093ENST00000497705ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000445937ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000531443ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000517566ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000452423ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000442977ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000521963ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000312046ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000449762ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000297447ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000521592ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-
5CDS-intronENST00000517669ENST00000497705ATP6V0E1chr5

172410919

+OXR1chr8

107709020

-

Top

FusionProtFeatures for ATP6V0E1_OXR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP6V0E1

O15342

OXR1

Q8N573

Vacuolar ATPase is responsible for acidifying a varietyof intracellular compartments in eukaryotic cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ATP6V0E1_OXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ATP6V0E1_OXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ATP6V0E1_OXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ATP6V0E1_OXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource