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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34552

FusionGeneSummary for SLC4A10_CACUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC4A10_CACUL1
Fusion gene ID: 34552
HgeneTgene
Gene symbol

SLC4A10

CACUL1

Gene ID

57282

143384

Gene namesolute carrier family 4 member 10CDK2 associated cullin domain 1
SynonymsNBCn2|NCBEC10orf46|CAC1
Cytomap

2q24.2

10q26.11

Type of geneprotein-codingprotein-coding
Descriptionsodium-driven chloride bicarbonate exchangersolute carrier family 4, sodium bicarbonate cotransporter-like, member 10solute carrier family 4, sodium bicarbonate transporter, member 10CDK2-associated and cullin domain-containing protein 1Cdk-Associated Cullin1cullin
Modification date2018052320180522
UniProtAcc

Q6U841

Q86Y37

Ensembl transtripts involved in fusion geneENST00000375514, ENST00000415876, 
ENST00000535165, ENST00000493021, 
ENST00000272716, ENST00000446997, 
ENST00000421911, 		ENST00000544392, 
ENST00000369151, ENST00000340214, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 4 X 2=24
# samples 34
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC4A10 [Title/Abstract] AND CACUL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW182981SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375514ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000375514ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000375514ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000415876ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000415876ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000415876ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000535165ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000535165ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000535165ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000493021ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000493021ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000493021ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000272716ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000272716ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000272716ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000446997ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000446997ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000446997ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000421911ENST00000544392SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-3UTRENST00000421911ENST00000369151SLC4A10chr2

162711926

-CACUL1chr10

120441208

+
intron-intronENST00000421911ENST00000340214SLC4A10chr2

162711926

-CACUL1chr10

120441208

+

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FusionProtFeatures for SLC4A10_CACUL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC4A10

Q6U841

CACUL1

Q86Y37

Cell cycle associated protein capable of promoting cellproliferation through the activation of CDK2 at the G1/S phasetransition. {ECO:0000269|PubMed:19829063}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC4A10_CACUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC4A10_CACUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC4A10_CACUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC4A10_CACUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC4A10C0009241Cognition Disorders1CTD_human
HgeneSLC4A10C0014544Epilepsy1CTD_human
HgeneSLC4A10C0085541Epilepsy, Frontal Lobe1CTD_human
HgeneSLC4A10C0151740Intracranial Hypertension1CTD_human
HgeneSLC4A10C3714756Intellectual Disability1CTD_human