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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34551

FusionGeneSummary for SLC4A10_ARL13B

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC4A10_ARL13B
Fusion gene ID: 34551
HgeneTgene
Gene symbol

SLC4A10

ARL13B

Gene ID

57282

200894

Gene namesolute carrier family 4 member 10ADP ribosylation factor like GTPase 13B
SynonymsNBCn2|NCBEARL2L1|JBTS8
Cytomap

2q24.2

3q11.1-q11.2

Type of geneprotein-codingprotein-coding
Descriptionsodium-driven chloride bicarbonate exchangersolute carrier family 4, sodium bicarbonate cotransporter-like, member 10solute carrier family 4, sodium bicarbonate transporter, member 10ADP-ribosylation factor-like protein 13BADP-ribosylation factor-like 13BADP-ribosylation factor-like 2-like 1ARL2-like protein 1
Modification date2018052320180523
UniProtAcc

Q6U841

Q3SXY8

Ensembl transtripts involved in fusion geneENST00000375514, ENST00000415876, 
ENST00000535165, ENST00000493021, 
ENST00000272716, ENST00000446997, 
ENST00000421911, 
ENST00000535334, 
ENST00000303097, ENST00000394222, 
ENST00000539730, ENST00000471138, 
ENST00000486562, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 2=18
# samples 34
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC4A10 [Title/Abstract] AND ARL13B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ338030SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000375514ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000375514ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000375514ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000375514ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000375514ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000375514ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-5UTRENST00000415876ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000415876ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000415876ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000415876ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000415876ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000415876ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-5UTRENST00000535165ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000535165ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000535165ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000535165ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000535165ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000535165ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-5UTRENST00000493021ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-intronENST00000493021ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-intronENST00000493021ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-intronENST00000493021ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-intronENST00000493021ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
3UTR-intronENST00000493021ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-5UTRENST00000272716ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000272716ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000272716ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000272716ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000272716ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000272716ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-5UTRENST00000446997ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000446997ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000446997ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000446997ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000446997ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000446997ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-5UTRENST00000421911ENST00000535334SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000421911ENST00000303097SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000421911ENST00000394222SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000421911ENST00000539730SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000421911ENST00000471138SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+
5CDS-intronENST00000421911ENST00000486562SLC4A10chr2

162696386

+ARL13Bchr3

93722615

+

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FusionProtFeatures for SLC4A10_ARL13B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC4A10

Q6U841

ARL13B

Q3SXY8

Cilium-specific protein required to control themicrotubule-based, ciliary axoneme structure. May act bymaintaining the association between IFT subcomplexes A and B.Binds GTP but is not able to hydrolyze it; the GTPase activityremains unclear. Required to pattern the neural tube. Involved incerebral cortex development: required for the initial formation ofa polarized radial glial scaffold, the first step in theconstruction of the cerebral cortex, by regulating ciliarysignaling. Regulates the migration and placement of postmitoticinterneurons in the developing cerebral cortex. May regulateendocytic recycling traffic; however, additional evidences arerequired to confirm these data. {ECO:0000269|PubMed:23150559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC4A10_ARL13B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC4A10_ARL13B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC4A10_ARL13B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC4A10_ARL13B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC4A10C0009241Cognition Disorders1CTD_human
HgeneSLC4A10C0014544Epilepsy1CTD_human
HgeneSLC4A10C0085541Epilepsy, Frontal Lobe1CTD_human
HgeneSLC4A10C0151740Intracranial Hypertension1CTD_human
HgeneSLC4A10C3714756Intellectual Disability1CTD_human
TgeneARL13BC2676771JOUBERT SYNDROME 8 (disorder)2CTD_human;UNIPROT