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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34544

FusionGeneSummary for SLC45A3_ZNFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC45A3_ZNFX1
Fusion gene ID: 34544
HgeneTgene
Gene symbol

SLC45A3

ZNFX1

Gene ID

85414

57169

Gene namesolute carrier family 45 member 3zinc finger NFX1-type containing 1
SynonymsIPCA-2|IPCA-6|IPCA-8|IPCA6|PCANAP2|PCANAP6|PCANAP8|PRST-
Cytomap

1q32.1

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 45 member 3prostate cancer associated protein 2prostate cancer associated protein 6prostate cancer associated protein 8prostate cancer-associated gene 2prostate cancer-associated gene 6prostate cancer-associated gene 8prosteinNFX1-type zinc finger-containing protein 1
Modification date2018033020180523
UniProtAcc

Q96JT2

Q9P2E3

Ensembl transtripts involved in fusion geneENST00000460934, ENST00000367145, 
ENST00000371754, ENST00000469991, 
ENST00000371752, ENST00000396105, 
Fusion gene scores* DoF score18 X 6 X 2=21627 X 5 X 14=1890
# samples 3831
** MAII scorelog2(38/216*10)=0.814968106167479
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(31/1890*10)=-2.6080461138342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC45A3 [Title/Abstract] AND ZNFX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-8260-01ASLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000460934ENST00000371754SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-intronENST00000460934ENST00000469991SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000460934ENST00000371752SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000460934ENST00000396105SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-intronENST00000367145ENST00000371754SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-intronENST00000367145ENST00000469991SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000367145ENST00000371752SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000367145ENST00000396105SLC45A3chr1

205626979

-ZNFX1chr20

47863418

-

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FusionProtFeatures for SLC45A3_ZNFX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC45A3

Q96JT2

ZNFX1

Q9P2E3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC45A3_ZNFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC45A3_ZNFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC45A3ZNFX1ENO1, SHMT2, MOV10, NXF1, XPO1, FYN, CSDE1, DROSHA, SS18L2, AMZ2, MIEF1, IMP3, DDX27, CDK4, HSF2, PCDH1, PDK1, SCAF11, UGGT1, CXXC4, TUBA1C, DRC1, LACTB, STRAP, OS9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC45A3_ZNFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC45A3_ZNFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource