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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34524

FusionGeneSummary for SLC45A2_AMACR

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC45A2_AMACR
Fusion gene ID: 34524
HgeneTgene
Gene symbol

SLC45A2

AMACR

Gene ID

51151

23600

Gene namesolute carrier family 45 member 2alpha-methylacyl-CoA racemase
Synonyms1A1|AIM1|MATP|OCA4|SHEP5AMACRD|CBAS4|P504S|RACE|RM
Cytomap

5p13.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated transporter proteinmelanoma antigen AIM1protein AIM-1underwhitealpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
Modification date2018051920180522
UniProtAcc

Q9UMX9

Q9UHK6

Ensembl transtripts involved in fusion geneENST00000296589, ENST00000342059, 
ENST00000382102, ENST00000509381, 
ENST00000345083, 
ENST00000335606, 
ENST00000382072, ENST00000514195, 
ENST00000382085, ENST00000502637, 
ENST00000441713, ENST00000426255, 
ENST00000512079, ENST00000382068, 
Fusion gene scores* DoF score3 X 1 X 3=93 X 3 X 2=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC45A2 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAMACR

GO:0008206

bile acid metabolic process

10655068


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-BL-A0C8-01BSLC45A2chr5

33982341

-AMACRchr5

34006004

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000296589ENST00000335606SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000296589ENST00000382072SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000514195SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000382085SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000502637SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000441713SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000426255SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000512079SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000296589ENST00000382068SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-3CDSENST00000342059ENST00000335606SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-3CDSENST00000342059ENST00000382072SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000514195SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000382085SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000502637SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000441713SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000426255SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000512079SLC45A2chr5

33982341

-AMACRchr5

34006004

-
intron-5UTRENST00000342059ENST00000382068SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000382102ENST00000335606SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000382102ENST00000382072SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000514195SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000382085SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000502637SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000441713SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000426255SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000512079SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000382102ENST00000382068SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000509381ENST00000335606SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000509381ENST00000382072SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000514195SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000382085SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000502637SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000441713SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000426255SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000512079SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000509381ENST00000382068SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000345083ENST00000335606SLC45A2chr5

33982341

-AMACRchr5

34006004

-
In-frameENST00000345083ENST00000382072SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000514195SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000382085SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000502637SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000441713SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000426255SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000512079SLC45A2chr5

33982341

-AMACRchr5

34006004

-
5CDS-5UTRENST00000345083ENST00000382068SLC45A2chr5

33982341

-AMACRchr5

34006004

-

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FusionProtFeatures for SLC45A2_AMACR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC45A2

Q9UMX9

AMACR

Q9UHK6

Melanocyte differentiation antigen. May transportsubstances required for melanin biosynthesis (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27132_138187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27160_184187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-271_46187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-2768_68187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-2790_110187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26132_138187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26160_184187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-261_46187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-2668_68187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-2690_110187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27111_131187531TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27139_159187531TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-2747_67187531TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-2769_89187531TransmembraneHelical%3B Name%3D2
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26111_131187461TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26139_159187461TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-2647_67187461TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-2669_89187461TransmembraneHelical%3B Name%3D2
TgeneAMACRchr5:33982341chr5:34006004ENST00000335606-05380_38282383MotifNote=Microbody targeting signal
TgeneAMACRchr5:33982341chr5:34006004ENST00000382072-04380_38282199MotifNote=Microbody targeting signal
TgeneAMACRchr5:33982341chr5:34006004ENST00000382085-06380_38282395MotifNote=Microbody targeting signal
TgeneAMACRchr5:33982341chr5:34006004ENST00000441713-04380_38282230MotifNote=Microbody targeting signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27206_216187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27238_318187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27340_366187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27388_398187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27420_425187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27447_477187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27499_504187531Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27526_530187531Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16132_138-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16160_184-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-161_46-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16206_216-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16238_318-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16340_366-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16388_398-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16420_425-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16447_477-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16499_504-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16526_530-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-1668_68-31472Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-1690_110-31472Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26206_216187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26238_318187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26340_366187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26388_398187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26420_425187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26447_477187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26499_504187461Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26526_530187461Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27185_205187531TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27217_237187531TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27319_339187531TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27367_387187531TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27399_419187531TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27426_446187531TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27478_498187531TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000296589-27505_525187531TransmembraneHelical%3B Name%3D12
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16111_131-31472TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16139_159-31472TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16185_205-31472TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16217_237-31472TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16319_339-31472TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16367_387-31472TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16399_419-31472TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16426_446-31472TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16478_498-31472TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-1647_67-31472TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-16505_525-31472TransmembraneHelical%3B Name%3D12
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000342059-1669_89-31472TransmembraneHelical%3B Name%3D2
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26185_205187461TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26217_237187461TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26319_339187461TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26367_387187461TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26399_419187461TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26426_446187461TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26478_498187461TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:34006004ENST00000382102-26505_525187461TransmembraneHelical%3B Name%3D12


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FusionGeneSequence for SLC45A2_AMACR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC45A2_AMACR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC45A2GAPDHS, EGFR, SQRDL, UBB, ATG9A, CYHR1, FAM63A, PCNXL3, ATP2B2, MID1IP1, GTF2E1, AMFR, TMEM63AAMACRPEX5, FKBP5, HSP90AA5P, PSMG3, PSMG4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC45A2_AMACR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC45A2_AMACR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC45A2C1847836Oculocutaneous Albinism, Type IV5CTD_human;ORPHANET;UNIPROT
HgeneSLC45A2C0025202melanoma2CTD_human
HgeneSLC45A2C0007117Basal cell carcinoma1CTD_human
HgeneSLC45A2C0007137Squamous cell carcinoma1CTD_human
HgeneSLC45A2C0236969Substance-Related Disorders1CTD_human
TgeneAMACRC0033578Prostatic Neoplasms3CTD_human
TgeneAMACRC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneAMACRC3280428Alpha-Methylacyl-CoA Racemase Deficiency2UNIPROT
TgeneAMACRC0001430Adenoma1CTD_human
TgeneAMACRC0009404Colorectal Neoplasms1CTD_human
TgeneAMACRC0023895Liver diseases1CTD_human
TgeneAMACRC0027888Hereditary Motor and Sensory Neuropathies1CTD_human
TgeneAMACRC0036341Schizophrenia1PSYGENET
TgeneAMACRC1858328Bile acid synthesis defect, congenital, 41CTD_human;ORPHANET;UNIPROT