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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34503

FusionGeneSummary for SLC44A1_FSD1L

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC44A1_FSD1L
Fusion gene ID: 34503
HgeneTgene
Gene symbol

SLC44A1

FSD1L

Gene ID

23446

83856

Gene namesolute carrier family 44 member 1fibronectin type III and SPRY domain containing 1 like
SynonymsCD92|CDW92|CHTL1|CTL1CCDC10|CSDUFD1|FSD1CL|FSD1NL|MIR1
Cytomap

9q31.1-q31.2

9q31.2

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 1CDW92 antigensolute carrier family 44 (choline transporter), member 1FSD1-like proteinFSD1 C-terminal likeFSD1 N-terminal likecoiled-coil domain containing 10cystatin and DUF19 domain containing 1
Modification date2018051920180519
UniProtAcc

Q8WWI5

Q9BXM9

Ensembl transtripts involved in fusion geneENST00000374723, ENST00000374720, 
ENST00000374724, ENST00000343170, 
ENST00000607692, 
ENST00000495708, 
ENST00000374710, ENST00000481272, 
ENST00000484973, ENST00000539376, 
ENST00000394926, ENST00000480279, 
ENST00000374707, ENST00000374716, 
Fusion gene scores* DoF score6 X 5 X 5=1502 X 2 X 2=8
# samples 62
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SLC44A1 [Title/Abstract] AND FSD1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-63-A5MW-01ASLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000374723ENST00000495708SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000374710SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000481272SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000484973SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000539376SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000394926SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000480279SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000374707SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374723ENST00000374716SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000495708SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000374710SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000481272SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000484973SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000539376SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000394926SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000480279SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000374707SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374720ENST00000374716SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000495708SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000374710SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000481272SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000484973SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000539376SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000394926SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000480279SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000374707SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
5CDS-intronENST00000374724ENST00000374716SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000495708SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000374710SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000481272SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000484973SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000539376SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000394926SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000480279SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000374707SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000343170ENST00000374716SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000495708SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000374710SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000481272SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000484973SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000539376SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000394926SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000480279SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000374707SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+
intron-intronENST00000607692ENST00000374716SLC44A1chr9

108097980

+FSD1Lchr9

108308639

+

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FusionProtFeatures for SLC44A1_FSD1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC44A1

Q8WWI5

FSD1L

Q9BXM9

Choline transporter. May be involved in membranesynthesis and myelin production. {ECO:0000269|PubMed:19357133}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC44A1_FSD1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC44A1_FSD1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC44A1NUDT21, KCNE3, C11orf58, ELAVL1, TSPAN17, PTH1R, NT5E, LYPD3, UPK1A, TMEM128, LRRC8B, TRIM25FSD1LAPP, LYN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC44A1_FSD1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC44A1_FSD1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource