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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34476

FusionGeneSummary for SLC3A1_ZNF341

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC3A1_ZNF341
Fusion gene ID: 34476
HgeneTgene
Gene symbol

SLC3A1

ZNF341

Gene ID

6519

84905

Gene namesolute carrier family 3 member 1zinc finger protein 341
SynonymsATR1|CSNU1|D2H|NBAT|RBAT-
Cytomap

2p21

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionneutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acidzinc finger protein 341
Modification date2018052320180523
UniProtAcc

Q07837

Q9BYN7

Ensembl transtripts involved in fusion geneENST00000260649, ENST00000409387, 
ENST00000410056, ENST00000409741, 
ENST00000409229, ENST00000409380, 
ENST00000409294, ENST00000409740, 
ENST00000375200, ENST00000342427, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SLC3A1 [Title/Abstract] AND ZNF341 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP270725SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260649ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000260649ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409387ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409387ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000410056ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000410056ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409741ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409741ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409229ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
5CDS-intronENST00000409229ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409380ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409380ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409294ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409294ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409740ENST00000375200SLC3A1chr2

44507885

+ZNF341chr20

32375318

+
intron-intronENST00000409740ENST00000342427SLC3A1chr2

44507885

+ZNF341chr20

32375318

+

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FusionProtFeatures for SLC3A1_ZNF341


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC3A1

Q07837

ZNF341

Q9BYN7

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC3A1_ZNF341


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC3A1_ZNF341


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC3A1_ZNF341


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC3A1_ZNF341


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC3A1C0010691Cystinuria10CTD_human;HPO;ORPHANET;UNIPROT
HgeneSLC3A1C1848030Hypotonia-Cystinuria Syndrome1CTD_human;ORPHANET