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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34472

FusionGeneSummary for SLC39A9_RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A9_RAD51B
Fusion gene ID: 34472
HgeneTgene
Gene symbol

SLC39A9

RAD51B

Gene ID

55334

5890

Gene namesolute carrier family 39 member 9RAD51 paralog B
SynonymsZIP-9|ZIP9R51H2|RAD51L1|REC2
Cytomap

14q24.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP9solute carrier family 39 (zinc transporter), member 9zinc transporter SLC39A9zrt- and Irt-like protein 9DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2018051920180523
UniProtAcc

Q9NUM3

O15315

Ensembl transtripts involved in fusion geneENST00000555245, ENST00000556605, 
ENST00000336643, ENST00000031146, 
ENST00000557046, 		ENST00000487861, 
ENST00000471583, ENST00000487270, 
ENST00000488612, ENST00000390683, 
ENST00000469165, 
Fusion gene scores* DoF score6 X 4 X 4=9625 X 15 X 8=3000
# samples 733
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/3000*10)=-3.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A9 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1XQ-01ASLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000555245ENST00000487861SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
intron-intronENST00000555245ENST00000471583SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
intron-intronENST00000555245ENST00000487270SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
intron-intronENST00000555245ENST00000488612SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
intron-intronENST00000555245ENST00000390683SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
intron-intronENST00000555245ENST00000469165SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000487861SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000471583SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000487270SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000488612SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000390683SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000556605ENST00000469165SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000487861SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000471583SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000487270SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000488612SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000390683SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000336643ENST00000469165SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000487861SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000471583SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000487270SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000488612SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000390683SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000031146ENST00000469165SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000487861SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000471583SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000487270SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000488612SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000390683SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+
5CDS-intronENST00000557046ENST00000469165SLC39A9chr14

69866182

+RAD51Bchr14

69149654

+

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FusionProtFeatures for SLC39A9_RAD51B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A9

Q9NUM3

RAD51B

O15315

May act as a zinc-influx transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A9_RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A9_RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC39A9MOV10, NXF1, CD44, TTI2, FKRP, HIP1R, DNAJC13, TPST2, SLC25A24, OSTC, HPCAL1, CANT1, SYNGR3, METTL16, KIAA0368, SFXN5, MTX3, TTK, RMND1, GOLM1, SRPR, B4GALT5, STIM1, NR2F2, MTFP1, CDC23, IDH2, SLC25A17, HELLS, DNM1, ABCB8, MSH3, PXMP2, NEK7, PDXDC1, MPC2, BDH1, XPO7, RIF1, CCDC132, VAPB, MTX1, TBRG4, APOOLRAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A9_RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A9_RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human