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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34470

FusionGeneSummary for SLC39A9_MFF

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A9_MFF
Fusion gene ID: 34470
HgeneTgene
Gene symbol

SLC39A9

MFF

Gene ID

55334

56947

Gene namesolute carrier family 39 member 9mitochondrial fission factor
SynonymsZIP-9|ZIP9C2orf33|EMPF2|GL004
Cytomap

14q24.1

2q36.3

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP9solute carrier family 39 (zinc transporter), member 9zinc transporter SLC39A9zrt- and Irt-like protein 9mitochondrial fission factor
Modification date2018051920180519
UniProtAcc

Q9NUM3

Q9GZY8

Ensembl transtripts involved in fusion geneENST00000555245, ENST00000556605, 
ENST00000336643, ENST00000031146, 
ENST00000557046, 
ENST00000304593, 
ENST00000476924, ENST00000353339, 
ENST00000354503, ENST00000409565, 
ENST00000409616, ENST00000337110, 
ENST00000524634, ENST00000349901, 
ENST00000392059, 
Fusion gene scores* DoF score6 X 4 X 4=963 X 4 X 3=36
# samples 75
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC39A9 [Title/Abstract] AND MFF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMFF

GO:0051260

protein homooligomerization

18353969

TgeneMFF

GO:0090141

positive regulation of mitochondrial fission

23283981|23530241

TgeneMFF

GO:0090314

positive regulation of protein targeting to membrane

23283981


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC003191SLC39A9chr14

69865776

+MFFchr2

228190007

+
ChiTaRS3.1BF315963SLC39A9chr14

69865776

+MFFchr2

228190008

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000555245ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-3UTRENST00000555245ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-intronENST00000555245ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-3UTRENST00000556605ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000556605ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-intronENST00000556605ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-3UTRENST00000336643ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000336643ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-intronENST00000336643ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-3UTRENST00000031146ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-5UTRENST00000031146ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190007

+
5UTR-intronENST00000031146ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-3UTRENST00000557046ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000557046ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-intronENST00000557046ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190007

+
intron-5UTRENST00000555245ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-3UTRENST00000555245ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000555245ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-intronENST00000555245ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-3UTRENST00000556605ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000556605ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-intronENST00000556605ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-3UTRENST00000336643ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000336643ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-intronENST00000336643ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-3UTRENST00000031146ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-5UTRENST00000031146ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190008

+
5UTR-intronENST00000031146ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000304593SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-3UTRENST00000557046ENST00000476924SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000353339SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000354503SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000409565SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000409616SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000337110SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000524634SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-5UTRENST00000557046ENST00000349901SLC39A9chr14

69865776

+MFFchr2

228190008

+
intron-intronENST00000557046ENST00000392059SLC39A9chr14

69865776

+MFFchr2

228190008

+

Top

FusionProtFeatures for SLC39A9_MFF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A9

Q9NUM3

MFF

Q9GZY8

May act as a zinc-influx transporter. {ECO:0000250}. Plays a role in mitochondrial and peroxisomal fission.Promotes the recruitment and association of the fission mediatordynamin-related protein 1 (DNM1L) to the mitochondrial surface.May be involved in regulation of synaptic vesicle membranedynamics by recruitment of DNM1L to clathrin-containing vesicles.{ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A9_MFF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A9_MFF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A9_MFF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A9_MFF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource