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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34462

FusionGeneSummary for SLC39A6_SLC39A6

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A6_SLC39A6
Fusion gene ID: 34462
HgeneTgene
Gene symbol

SLC39A6

SLC39A6

Gene ID

25800

25800

Gene namesolute carrier family 39 member 6solute carrier family 39 member 6
SynonymsLIV-1|ZIP6LIV-1|ZIP6
Cytomap

18q12.2

18q12.2

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP6LIV-1 protein, estrogen regulatedZIP-6estrogen-regulated protein LIV-1solute carrier family 39 (metal ion transporter), member 6solute carrier family 39 (zinc transporter), member 6zrt- and Irt-like protein 6zinc transporter ZIP6LIV-1 protein, estrogen regulatedZIP-6estrogen-regulated protein LIV-1solute carrier family 39 (metal ion transporter), member 6solute carrier family 39 (zinc transporter), member 6zrt- and Irt-like protein 6
Modification date2018052320180523
UniProtAcc

Q13433

Q13433

Ensembl transtripts involved in fusion geneENST00000269187, ENST00000590986, 
ENST00000440549, 
ENST00000269187, 
ENST00000590986, ENST00000440549, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 2=18
# samples 64
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC39A6 [Title/Abstract] AND SLC39A6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC39A6

GO:0006882

cellular zinc ion homeostasis

15642354

HgeneSLC39A6

GO:0071578

zinc ion import across plasma membrane

15642354

TgeneSLC39A6

GO:0006882

cellular zinc ion homeostasis

15642354

TgeneSLC39A6

GO:0071578

zinc ion import across plasma membrane

15642354


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE166679SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000269187ENST00000269187SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000269187ENST00000590986SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000269187ENST00000440549SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000590986ENST00000269187SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000590986ENST00000590986SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000590986ENST00000440549SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000440549ENST00000269187SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000440549ENST00000590986SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-
intron-3CDSENST00000440549ENST00000440549SLC39A6chr18

33696740

+SLC39A6chr18

33703540

-

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FusionProtFeatures for SLC39A6_SLC39A6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A6

Q13433

SLC39A6

Q13433

May act as a zinc-influx transporter.{ECO:0000269|PubMed:12839489}. May act as a zinc-influx transporter.{ECO:0000269|PubMed:12839489}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A6_SLC39A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A6_SLC39A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A6_SLC39A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A6_SLC39A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A6C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC39A6C0027627Neoplasm Metastasis1CTD_human
HgeneSLC39A6C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneSLC39A6C1458155Mammary Neoplasms1CTD_human
TgeneSLC39A6C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC39A6C0027627Neoplasm Metastasis1CTD_human
TgeneSLC39A6C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneSLC39A6C1458155Mammary Neoplasms1CTD_human