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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34461

FusionGeneSummary for SLC39A6_RHOA

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A6_RHOA
Fusion gene ID: 34461
HgeneTgene
Gene symbol

SLC39A6

RHOA

Gene ID

25800

387

Gene namesolute carrier family 39 member 6ras homolog family member A
SynonymsLIV-1|ZIP6ARH12|ARHA|RHO12|RHOH12
Cytomap

18q12.2

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP6LIV-1 protein, estrogen regulatedZIP-6estrogen-regulated protein LIV-1solute carrier family 39 (metal ion transporter), member 6solute carrier family 39 (zinc transporter), member 6zrt- and Irt-like protein 6transforming protein RhoAAplysia ras-related homolog 12oncogene RHO H12small GTP binding protein RhoA
Modification date2018052320180527
UniProtAcc

Q13433

P61586

Ensembl transtripts involved in fusion geneENST00000269187, ENST00000590986, 
ENST00000440549, 
ENST00000418115, 
ENST00000454011, ENST00000422781, 
ENST00000265538, 
Fusion gene scores* DoF score6 X 6 X 3=10810 X 9 X 4=360
# samples 611
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A6 [Title/Abstract] AND RHOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC39A6

GO:0006882

cellular zinc ion homeostasis

15642354

HgeneSLC39A6

GO:0071578

zinc ion import across plasma membrane

15642354

TgeneRHOA

GO:0007266

Rho protein signal transduction

26529257

TgeneRHOA

GO:0016477

cell migration

26529257

TgeneRHOA

GO:0032956

regulation of actin cytoskeleton organization

25911094

TgeneRHOA

GO:0035385

Roundabout signaling pathway

26529257

TgeneRHOA

GO:0036089

cleavage furrow formation

16103226

TgeneRHOA

GO:0051496

positive regulation of stress fiber assembly

15467718

TgeneRHOA

GO:0060193

positive regulation of lipase activity

19887681

TgeneRHOA

GO:0071222

cellular response to lipopolysaccharide

19734146

TgeneRHOA

GO:0071902

positive regulation of protein serine/threonine kinase activity

8617235


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU141201SLC39A6chr18

33689030

-RHOAchr3

49449401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000269187ENST00000418115SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000269187ENST00000454011SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000269187ENST00000422781SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-5UTRENST00000269187ENST00000265538SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-5UTRENST00000590986ENST00000418115SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000590986ENST00000454011SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000590986ENST00000422781SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-5UTRENST00000590986ENST00000265538SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-5UTRENST00000440549ENST00000418115SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000440549ENST00000454011SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-intronENST00000440549ENST00000422781SLC39A6chr18

33689030

-RHOAchr3

49449401

-
intron-5UTRENST00000440549ENST00000265538SLC39A6chr18

33689030

-RHOAchr3

49449401

-

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FusionProtFeatures for SLC39A6_RHOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A6

Q13433

RHOA

P61586

May act as a zinc-influx transporter.{ECO:0000269|PubMed:12839489}. Regulates a signal transduction pathway linking plasmamembrane receptors to the assembly of focal adhesions and actinstress fibers. Involved in a microtubule-dependent signal that isrequired for the myosin contractile ring formation during cellcycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity.May be an activator of PLCE1. Activated by ARHGEF2, which promotesthe exchange of GDP for GTP. Essential for the SPATA13-mediatedregulation of cell migration and adhesion assembly anddisassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Regulates a signal transduction pathway linkingplasma membrane receptors to the assembly of focal adhesions andactin stress fibers. Involved in a microtubule-dependent signalthat is required for the myosin contractile ring formation duringcell cycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. May be an activator of PLCE1.Activated by ARHGEF2, which promotes the exchange of GDP for GTP.Essential for the SPATA13-mediated regulation of cell migrationand adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1signaling pathway plays an important role in ERBB2-dependentstabilization of microtubules at the cell cortex. It controls thelocalization of APC and CLASP2 to the cell membrane, via theregulation of GSK3B activity. In turn, membrane-bound APC allowsthe localization of the MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization (Bysimilarity). Regulates KCNA2 potassium channel activity byreducing its location at the cell surface in response to CHRM1activation; promotes KCNA2 endocytosis (PubMed:9635436,PubMed:19403695). {ECO:0000250, ECO:0000269|PubMed:12900402,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794,ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854,ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:8910519,ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pestis, vector of the plague.{ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pseudotuberculosis, which causesgastrointestinal disorders. {ECO:0000269|PubMed:12062101,ECO:0000269|PubMed:12538863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A6_RHOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A6_RHOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A6_RHOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A6_RHOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A6C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC39A6C0027627Neoplasm Metastasis1CTD_human
HgeneSLC39A6C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneSLC39A6C1458155Mammary Neoplasms1CTD_human
TgeneRHOAC0038356Stomach Neoplasms3CTD_human
TgeneRHOAC0020981Angioimmunoblastic Lymphadenopathy2CTD_human
TgeneRHOAC0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneRHOAC0005695Bladder Neoplasm1CTD_human
TgeneRHOAC0027626Neoplasm Invasiveness1CTD_human
TgeneRHOAC0033687Proteinuria1CTD_human
TgeneRHOAC0079772T-Cell Lymphoma1CTD_human
TgeneRHOAC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneRHOAC0235833Congenital diaphragmatic hernia1CTD_human