FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34450

FusionGeneSummary for SLC39A1_RAB13

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A1_RAB13
Fusion gene ID: 34450
HgeneTgene
Gene symbol

SLC39A1

RAB13

Gene ID

27173

5872

Gene namesolute carrier family 39 member 1RAB13, member RAS oncogene family
SynonymsZIP1|ZIRTLGIG4
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP1solute carrier family 39 (zinc transporter), member 1solute carrier family 39 (zinc transporter), member 3zrt- and Irt-like protein 1ras-related protein Rab-13RAS-associated protein RAB13cell growth-inhibiting gene 4 proteingrowth-inhibiting gene 4 protein
Modification date2018052320180523
UniProtAcc

Q9NY26

P51153

Ensembl transtripts involved in fusion geneENST00000356205, ENST00000368623, 
ENST00000368621, ENST00000310483, 
ENST00000537590, ENST00000461071, 
ENST00000368575, ENST00000462680, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 4 X 4=96
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A1 [Title/Abstract] AND RAB13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-43-2576-01ASLC39A1chr1

153934696

-RAB13chr1

153957257

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356205ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
5CDS-5UTRENST00000356205ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-
Frame-shiftENST00000368623ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
5CDS-5UTRENST00000368623ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-
In-frameENST00000368621ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
5CDS-5UTRENST00000368621ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-
Frame-shiftENST00000310483ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
5CDS-5UTRENST00000310483ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-
intron-3CDSENST00000537590ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
intron-5UTRENST00000537590ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-
intron-3CDSENST00000461071ENST00000368575SLC39A1chr1

153934696

-RAB13chr1

153957257

-
intron-5UTRENST00000461071ENST00000462680SLC39A1chr1

153934696

-RAB13chr1

153957257

-

Top

FusionProtFeatures for SLC39A1_RAB13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A1

Q9NY26

RAB13

P51153

Mediates zinc uptake. May function as a major endogenouszinc uptake transporter in many cells of the body. Responsible forthe rapid uptake and accumulation of physiologically effectivezinc in prostate cells. {ECO:0000269|PubMed:12888280}. The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab is involved in endocytic recyclingand regulates the transport to the plasma membrane oftransmembrane proteins like the tight junction proteinOCLN/occludin. Thereby, it regulates the assembly and the activityof tight junctions. Moreover, it may also regulate tight junctionassembly by activating the PKA signaling pathway and byreorganizing the actin cytoskeleton through the activation of thedownstream effectors PRKACA and MICALL2 respectively. Through itsrole in tight junction assembly, may play a role in theestablishment of Sertoli cell barrier. Plays also a role inangiogenesis through regulation of endothelial cells chemotaxis.Also involved in neurite outgrowth. Has also been proposed to playa role in post-Golgi membrane trafficking from the TGN to therecycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucosetransporter GLUT4 and therefore may play a role in glucosehomeostasis. {ECO:0000269|PubMed:12058051,ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189,ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367,ECO:0000269|PubMed:20008558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLC39A1_RAB13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLC39A1_RAB13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC39A1CERS2, MOV10, NXF1, NOTCH3, LSG1, SUPT6H, P2RY12, PTGER3, LPAR1, SCARA3, TNFRSF1A, SPPL2B, GPR114, SLC7A1, NME2P1, CLEC2D, VIPR2, FZD10, HTR2C, C3AR1, FPR2, FCGRT, SYAP1RAB13PDE6D, RABGAP1L, UBL4A, RPA3, RPA2, RPA1, SRPRB, F3, VSIG4, TGOLN2, GDI1, SORT1, PCGF1, DPPA4, NANOG, POU5F1, DUSP19, DUSP6, RAB8B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC39A1_RAB13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SLC39A1_RAB13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A1C0033578Prostatic Neoplasms2CTD_human
HgeneSLC39A1C0035228Respiratory Hypersensitivity1CTD_human