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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34447

FusionGeneSummary for SLC39A1_BLK

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A1_BLK
Fusion gene ID: 34447
HgeneTgene
Gene symbol

SLC39A1

BLK

Gene ID

27173

640

Gene namesolute carrier family 39 member 1BLK proto-oncogene, Src family tyrosine kinase
SynonymsZIP1|ZIRTLMODY11
Cytomap

1q21.3

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP1solute carrier family 39 (zinc transporter), member 1solute carrier family 39 (zinc transporter), member 3zrt- and Irt-like protein 1tyrosine-protein kinase BlkB lymphoid tyrosine kinaseBLK nonreceptor tyrosine kinaseb lymphocyte kinasep55-Blk
Modification date2018052320180528
UniProtAcc

Q9NY26

P51451

Ensembl transtripts involved in fusion geneENST00000356205, ENST00000368623, 
ENST00000368621, ENST00000310483, 
ENST00000537590, ENST00000461071, 
ENST00000259089, ENST00000529894, 
ENST00000525389, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 3=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A1 [Title/Abstract] AND BLK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBLK

GO:0050853

B cell receptor signaling pathway

876631


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF743866SLC39A1chr1

153932381

-BLKchr8

11406547

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000356205ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000356205ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000356205ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000368623ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000368623ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000368623ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000368621ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000368621ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000368621ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000310483ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000310483ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000310483ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000537590ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000537590ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000537590ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000461071ENST00000259089SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-3CDSENST00000461071ENST00000529894SLC39A1chr1

153932381

-BLKchr8

11406547

+
intron-intronENST00000461071ENST00000525389SLC39A1chr1

153932381

-BLKchr8

11406547

+

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FusionProtFeatures for SLC39A1_BLK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A1

Q9NY26

BLK

P51451

Mediates zinc uptake. May function as a major endogenouszinc uptake transporter in many cells of the body. Responsible forthe rapid uptake and accumulation of physiologically effectivezinc in prostate cells. {ECO:0000269|PubMed:12888280}. Non-receptor tyrosine kinase involved in B-lymphocytedevelopment, differentiation and signaling. B-cell receptor (BCR)signaling requires a tight regulation of several protein tyrosinekinases and phosphatases, and associated coreceptors. Binding ofantigen to the B-cell antigen receptor (BCR) triggers signalingthat ultimately leads to B-cell activation. Signaling through BLKplays an important role in transmitting signals through surfaceimmunoglobulins and supports the pro-B to pre-B transition, aswell as the signaling for growth arrest and apoptosis downstreamof B-cell receptor. Specifically binds and phosphorylates CD79A at'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A,FCGR2B and FCGR2C. With FYN and LYN, plays an essential role inpre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation.Contributes also to BTK activation by indirectly stimulating BTKintramolecular autophosphorylation. In pancreatic islets, acts asa modulator of beta-cells function through the up-regulation ofPDX1 and NKX6-1 and consequent stimulation of insulin secretion inresponse to glucose. {ECO:0000269|PubMed:19667185,ECO:0000269|PubMed:8756631}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A1_BLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A1_BLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A1_BLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A1_BLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A1C0033578Prostatic Neoplasms2CTD_human
HgeneSLC39A1C0035228Respiratory Hypersensitivity1CTD_human
TgeneBLKC0003873Rheumatoid Arthritis2CTD_human
TgeneBLKC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneBLKC0026691Mucocutaneous Lymph Node Syndrome1CTD_human