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Fusion gene ID: 34446 |
FusionGeneSummary for SLC39A14_XPO7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC39A14_XPO7 | Fusion gene ID: 34446 | Hgene | Tgene | Gene symbol | SLC39A14 | XPO7 | Gene ID | 23516 | 23039 |
| Gene name | solute carrier family 39 member 14 | exportin 7 | |
| Synonyms | HCIN|HMNDYT2|LZT-Hs4|NET34|ZIP14|cig19 | EXP7|RANBP16 | |
| Cytomap | 8p21.3 | 8p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc transporter ZIP14LIV-1 subfamily of ZIP zinc transporter 4Zrt-, Irt-like protein 14solute carrier family 39 (metal ion transporter), member 14solute carrier family 39 (zinc transporter), member 14zrt- and Irt-like protein 14 | exportin-7RAN binding protein 16 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q15043 | Q9UIA9 | |
| Ensembl transtripts involved in fusion gene | ENST00000240095, ENST00000359741, ENST00000381237, ENST00000289952, | ENST00000434536, ENST00000252512, ENST00000518017, ENST00000433566, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 5 X 6 X 3=90 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC39A14 [Title/Abstract] AND XPO7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC39A14 | GO:0006882 | cellular zinc ion homeostasis | 15642354|21917916 |
| Hgene | SLC39A14 | GO:0071577 | zinc ion transmembrane transport | 21917916 |
| Hgene | SLC39A14 | GO:0071578 | zinc ion import across plasma membrane | 15642354 |
| Tgene | XPO7 | GO:0006611 | protein export from nucleus | 11024021 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-ZS-A9CF-02A | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000240095 | ENST00000434536 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-3CDS | ENST00000240095 | ENST00000252512 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000240095 | ENST00000518017 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000240095 | ENST00000433566 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-3CDS | ENST00000359741 | ENST00000434536 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-3CDS | ENST00000359741 | ENST00000252512 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000359741 | ENST00000518017 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000359741 | ENST00000433566 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-3CDS | ENST00000381237 | ENST00000434536 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-3CDS | ENST00000381237 | ENST00000252512 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000381237 | ENST00000518017 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| 5UTR-intron | ENST00000381237 | ENST00000433566 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| intron-3CDS | ENST00000289952 | ENST00000434536 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| intron-3CDS | ENST00000289952 | ENST00000252512 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| intron-intron | ENST00000289952 | ENST00000518017 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
| intron-intron | ENST00000289952 | ENST00000433566 | SLC39A14 | chr8 | 22224921 | + | XPO7 | chr8 | 21856266 | + |
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FusionProtFeatures for SLC39A14_XPO7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC39A14 | XPO7 |
| Broad-scope metal ion transporter with a preference forzinc uptake. Also mediates cellular uptake of nontransferrin-boundiron. {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142}. | Mediates the nuclear export of proteins (cargos) withbroad substrate specificity. In the nucleus binds cooperatively toits cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC)is mediated through binding to nucleoporins. Upon transit of anuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1and RANGAP1, respectively) cause release of the cargo from theexport receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclearexport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus. {ECO:0000269|PubMed:11024021,ECO:0000269|PubMed:15282546}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC39A14_XPO7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC39A14_XPO7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC39A14 | TMEM173, ELAVL1, ADRB2, TMEM17, TMEM216 | XPO7 | PTP4A3, C20orf24, BRF2, DDX19B, MAPK9, PDPK1, TAB1, RAN, NUP153, SIRT7, XPO1, SEPHS1, VPS37B, USP14, TLK2, UBE2I, TLK1, XRN2, EGFR, CARS, DPYSL2, JMJD6, RANBP3, SEC24C, SF1, AP2B1, CARM1, CTNNA1, DNAJB1, EIF4B, FAF1, GARS, GART, GFPT1, HIRIP3, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, PPM1G, PRMT3, SAMHD1, SEC23A, THUMPD3, TROVE2, TTC1, USP11, POLK, USO1, ENO1, MOV10, NXF1, CCDC8, BSG, CD274, VSIG2, NT5E, LYPD3, RP2, SCN2B, SCARA3, DSCR3, CCDC22, COMMD9, SH3GLB1, NTRK1, NPHP1, DAXX, FOXB1, FOXI2, CD70, VIPR2, FZD10, VASN, HTR2C, TMEM206, CDHR5, DLK2, CHRM4, OPRM1, APLNR, MAS1, EDNRB, VSIG1, SLC39A9, PDCD1, TMEM108, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC39A14_XPO7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC39A14_XPO7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC39A14 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
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