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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34433

FusionGeneSummary for SLC39A11_OPN3

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A11_OPN3
Fusion gene ID: 34433
HgeneTgene
Gene symbol

SLC39A11

OPN3

Gene ID

201266

23596

Gene namesolute carrier family 39 member 11opsin 3
SynonymsC17orf26|ZIP-11|ZIP11ECPN|PPP1R116
Cytomap

17q24.3-q25.1

1q43

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP11Zrt- and Irt-like protein 11solute carrier family 39 (metal ion transporter), member 11opsin-3encephalopsinopsin 3 (encephalopsin, panopsin)protein phosphatase 1, regulatory subunit 116
Modification date2018052320180523
UniProtAcc

Q8N1S5

Q9H1Y3

Ensembl transtripts involved in fusion geneENST00000255559, ENST00000542342, 
ENST00000579988, ENST00000579732, 
ENST00000366554, ENST00000331838, 
ENST00000469376, 
Fusion gene scores* DoF score15 X 9 X 10=13501 X 1 X 1=1
# samples 151
** MAII scorelog2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SLC39A11 [Title/Abstract] AND OPN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KC-A7F5-01ASLC39A11chr17

71027695

-OPN3chr1

241761299

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000255559ENST00000366554SLC39A11chr17

71027695

-OPN3chr1

241761299

-
Frame-shiftENST00000255559ENST00000331838SLC39A11chr17

71027695

-OPN3chr1

241761299

-
5CDS-5UTRENST00000255559ENST00000469376SLC39A11chr17

71027695

-OPN3chr1

241761299

-
Frame-shiftENST00000542342ENST00000366554SLC39A11chr17

71027695

-OPN3chr1

241761299

-
Frame-shiftENST00000542342ENST00000331838SLC39A11chr17

71027695

-OPN3chr1

241761299

-
5CDS-5UTRENST00000542342ENST00000469376SLC39A11chr17

71027695

-OPN3chr1

241761299

-
intron-3CDSENST00000579988ENST00000366554SLC39A11chr17

71027695

-OPN3chr1

241761299

-
intron-3CDSENST00000579988ENST00000331838SLC39A11chr17

71027695

-OPN3chr1

241761299

-
intron-5UTRENST00000579988ENST00000469376SLC39A11chr17

71027695

-OPN3chr1

241761299

-
Frame-shiftENST00000579732ENST00000366554SLC39A11chr17

71027695

-OPN3chr1

241761299

-
Frame-shiftENST00000579732ENST00000331838SLC39A11chr17

71027695

-OPN3chr1

241761299

-
5CDS-5UTRENST00000579732ENST00000469376SLC39A11chr17

71027695

-OPN3chr1

241761299

-

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FusionProtFeatures for SLC39A11_OPN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A11

Q8N1S5

OPN3

Q9H1Y3

Functions as a cellular zinc transporter.{ECO:0000250|UniProtKB:Q8BWY7}. May play a role in encephalic photoreception.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC39A11_OPN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC39A11_OPN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC39A11ELAVL1, EGFR, CD33, TMEM51, CD274, PVRIG, SLAMF1, TMEFF1, WBP1, SPN, SCN2B, PON2, IZUMO1, EPHA1, FAM174A, SIGLEC12, GAPDHS, GALNT16, LRRC4C, A2ML1, ST3GAL1, HAL, PCDHB16, CLEC2D, VASN, PMEL, NTRK3OPN3EIF2B5, EIF2B4, EIF2B2, EIF2B3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC39A11_OPN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC39A11_OPN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource