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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3440

FusionGeneSummary for ATP6V0A1_STAT5A

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP6V0A1_STAT5A
Fusion gene ID: 3440
HgeneTgene
Gene symbol

ATP6V0A1

STAT5A

Gene ID

535

6776

Gene nameATPase H+ transporting V0 subunit a1signal transducer and activator of transcription 5A
SynonymsATP6N1|ATP6N1A|Stv1|VPP1|Vph1|a1MGF|STAT5
Cytomap

17q21.2

17q21.2

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase 116 kDa subunit a isoform 1V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal V0 subunit a1ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)H(+)-transporting two-sector ATPase, signal transducer and activator of transcription 5A
Modification date2018052320180522
UniProtAcc

Q93050

P42229

Ensembl transtripts involved in fusion geneENST00000393829, ENST00000546249, 
ENST00000537728, ENST00000264649, 
ENST00000585525, ENST00000343619, 
ENST00000544137, ENST00000587797, 
ENST00000345506, ENST00000590949, 
ENST00000546010, ENST00000452307, 
ENST00000588868, ENST00000587646, 
Fusion gene scores* DoF score14 X 13 X 7=12743 X 3 X 3=27
# samples 144
** MAII scorelog2(14/1274*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP6V0A1 [Title/Abstract] AND STAT5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-BT-A20U-01AATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000393829ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000393829ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000393829ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000393829ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000393829ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000393829ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000546249ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000546249ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000546249ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000546249ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000546249ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000546249ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000537728ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000537728ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000537728ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000537728ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000537728ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000537728ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000264649ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000264649ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000264649ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000264649ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000264649ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000264649ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000585525ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000585525ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000585525ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000585525ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000585525ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000585525ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000343619ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000343619ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000343619ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000343619ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000343619ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000343619ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000544137ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-5UTRENST00000544137ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000544137ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000544137ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000544137ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
5UTR-intronENST00000544137ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-5UTRENST00000587797ENST00000345506ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-5UTRENST00000587797ENST00000590949ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-intronENST00000587797ENST00000546010ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-intronENST00000587797ENST00000452307ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-intronENST00000587797ENST00000588868ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+
intron-intronENST00000587797ENST00000587646ATP6V0A1chr17

40610981

+STAT5Achr17

40440074

+

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FusionProtFeatures for ATP6V0A1_STAT5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP6V0A1

Q93050

STAT5A

P42229

Required for assembly and activity of the vacuolarATPase. Potential role in differential targeting and regulation ofthe enzyme for a specific organelle (By similarity).{ECO:0000250}. Carries out a dual function: signal transduction andactivation of transcription. Mediates cellular responses to thecytokine KITLG/SCF and other growth factors. Mediates cellularresponses to ERBB4. May mediate cellular responses to activatedFGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element andactivates PRL-induced transcription. Regulates the expression ofmilk proteins during lactation. {ECO:0000269|PubMed:15534001}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP6V0A1_STAT5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP6V0A1_STAT5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP6V0A1ATP6V1B1, ATP6V1E1, ATP6V1D, PTRH2, MRPL50, MRPL46, SCFD1, MARCKSL1, PA2G4, RPS15, SLC25A3, SLC30A5, SRSF3, VAMP2, MRPL44, NONO, RPS18, CLIC1, SNX4, ZNF267, SEH1L, HLA-DQA1, HOXB5, MUC1, NUFIP1, CEACAM21, LGALS8, GNAZ, MCAM, ATP6AP2, TMEM185A, SERINC2, C17orf59, ATP5O, ATP6V0D1, NTRK1, TCTN3, TMEM216, TMEM67, CLTC, PTPN1, RAB5C, RAB7A, TFG, GOLT1B, CHMP4B, ATP6V0D2, KIAA2013, ATP6V0A2, BCAM, ATP6V0E1, SLC34A2, TMEM199, GPR114, MTUS2, SMPD3, TMEM63A, RNF19B, TLDC1, HTR3A, CD4, RGS20, SLC35D3, FZD10, MGST3, FAM131B, PTGIRSTAT5AJAK3, MAGEA12, PRTFDC1, ERBB4, EGFR, IL2RB, JAK2, ESR1, ESR2, PTPN11, CRKL, JAK1, BRCA1, BRCA2, MAPK1, SHC1, NMI, CD247, EPOR, PTPN1, NCOA1, HDAC1, CARM1, PRMT1, SMARCA4, FGFR2, PGR, GNB2, SQSTM1, MYB, EP300, NFKB1, SOCS7, BTK, INSR, CBL, CYP2C9, RBMX, AQP11, CSNK2B, EPAS1, FN1, GLUD1, STAT5A, UGT2B4, HELZ, TXNDC11, MRPS6, ZNF596, WASH2P, POM121C, LEF1, TCF12, PPARG, RUNX2, NLK, NARF, OLIG1, ADD3, DLAT, PDHA1, PDHB, ICAM5, PDHX, GDF15, FARS2, RNF13, R3HDM2, ERMP1, ILKAP, KRT87P, SPICE1, CRK, PDGFRB, STAT1, GHR, CTLA4, CBX5, STAT5B, TLR2, PDK2, PDK3, KLHL7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP6V0A1_STAT5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP6V0A1_STAT5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTAT5AC0024667Animal Mammary Neoplasms5CTD_human
TgeneSTAT5AC0024668Mammary Neoplasms, Experimental3CTD_human
TgeneSTAT5AC0001418Adenocarcinoma2CTD_human
TgeneSTAT5AC0007124Noninfiltrating Intraductal Carcinoma1CTD_human
TgeneSTAT5AC0024121Lung Neoplasms1CTD_human
TgeneSTAT5AC0032927Precancerous Conditions1CTD_human
TgeneSTAT5AC0151744Myocardial Ischemia1CTD_human
TgeneSTAT5AC0206692Carcinoma, Lobular1CTD_human
TgeneSTAT5AC1176475Ductal Carcinoma1CTD_human
TgeneSTAT5AC1458155Mammary Neoplasms1CTD_human