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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34382

FusionGeneSummary for SLC35G2_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC35G2_MBP
Fusion gene ID: 34382
HgeneTgene
Gene symbol

SLC35G2

MBP

Gene ID

80723

5553

Gene namesolute carrier family 35 member G2proteoglycan 2, pro eosinophil major basic protein
SynonymsTMEM22BMPG|MBP|MBP1|proMBP
Cytomap

3q22.3

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 35 member G2transmembrane protein 22bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052320180519
UniProtAcc

Q8TBE7

P02686

Ensembl transtripts involved in fusion geneENST00000472200, ENST00000446465, 
ENST00000393079, 
ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score2 X 3 X 3=1826 X 20 X 3=1560
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC35G2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA348465SLC35G2chr3

136574249

+MBPchr18

74691260

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000472200ENST00000382582SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-3UTRENST00000472200ENST00000355994SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-3UTRENST00000472200ENST00000397875SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-3UTRENST00000472200ENST00000397866SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-3UTRENST00000472200ENST00000397865SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000527041SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000359645SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000528160SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000397869SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000354542SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000526111SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000580402SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000579129SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000578193SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000397863SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000397860SLC35G2chr3

136574249

+MBPchr18

74691260

-
intron-intronENST00000472200ENST00000487778SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000446465ENST00000382582SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000446465ENST00000355994SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000446465ENST00000397875SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000446465ENST00000397866SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000446465ENST00000397865SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000527041SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000359645SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000528160SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000397869SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000354542SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000526111SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000580402SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000579129SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000578193SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000397863SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000397860SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000446465ENST00000487778SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000393079ENST00000382582SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000393079ENST00000355994SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000393079ENST00000397875SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000393079ENST00000397866SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-3UTRENST00000393079ENST00000397865SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000527041SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000359645SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000528160SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000397869SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000354542SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000526111SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000580402SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000579129SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000578193SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000397863SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000397860SLC35G2chr3

136574249

+MBPchr18

74691260

-
5CDS-intronENST00000393079ENST00000487778SLC35G2chr3

136574249

+MBPchr18

74691260

-

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FusionProtFeatures for SLC35G2_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC35G2

Q8TBE7

MBP

P02686

May play a role in cell proliferation.{ECO:0000305|PubMed:19148500}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC35G2_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC35G2_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC35G2_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC35G2_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC35G2C0025202melanoma1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human