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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34360

FusionGeneSummary for SLC35E2B_PFKFB4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC35E2B_PFKFB4
Fusion gene ID: 34360
HgeneTgene
Gene symbol

SLC35E2B

PFKFB4

Gene ID

728661

5210

Gene namesolute carrier family 35 member E2B6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
SynonymsSLC35E2-
Cytomap

1p36.33

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 35 member E2B6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 46PF-2-K/Fru-2,6-P2ase 46PF-2-K/Fru-2,6-P2ase testis-type isozymePFK/FBPase 4bifunctional enzyme with kinase and biphosphatase activities
Modification date2018040220180523
UniProtAcc

P0CK96

Q16877

Ensembl transtripts involved in fusion geneENST00000378662, ENST00000234800, 
ENST00000232375, ENST00000536104, 
ENST00000416568, ENST00000541519, 
ENST00000383734, ENST00000490115, 
ENST00000545984, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC35E2B [Title/Abstract] AND PFKFB4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GU-A764-01ASLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000378662ENST00000232375SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000378662ENST00000536104SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000378662ENST00000416568SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000378662ENST00000541519SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-intronENST00000378662ENST00000383734SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-5UTRENST00000378662ENST00000490115SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-3UTRENST00000378662ENST00000545984SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000234800ENST00000232375SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000234800ENST00000536104SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000234800ENST00000416568SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
Frame-shiftENST00000234800ENST00000541519SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-intronENST00000234800ENST00000383734SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-5UTRENST00000234800ENST00000490115SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-
5CDS-3UTRENST00000234800ENST00000545984SLC35E2Bchr1

1601103

-PFKFB4chr3

48563102

-

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FusionProtFeatures for SLC35E2B_PFKFB4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC35E2B

P0CK96

PFKFB4

Q16877

Putative transporter. {ECO:0000250}. Synthesis and degradation of fructose 2,6-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC35E2B_PFKFB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC35E2B_PFKFB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC35E2BPFKFB4GSK3B, CSNK2B, GADD45A, NXF1, PFKFB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC35E2B_PFKFB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC35E2B_PFKFB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource