FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34348

FusionGeneSummary for SLC35A4_PEX1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC35A4_PEX1
Fusion gene ID: 34348
HgeneTgene
Gene symbol

SLC35A4

PEX1

Gene ID

113829

339324

Gene namesolute carrier family 35 member A4zinc finger protein 260
Synonyms-OZRF1|PEX1|ZFP260
Cytomap

5q31.3

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionprobable UDP-sugar transporter protein SLC35A4solute carrier family 35 (UDP-galactose transporter), member A4tumor rejection antigenzinc finger protein 260zfp-260
Modification date2018052320180519
UniProtAcc

Q96G79

O43933

Ensembl transtripts involved in fusion geneENST00000323146, ENST00000508770, 
ENST00000514199, 
ENST00000438045, 
ENST00000248633, ENST00000428214, 
ENST00000541751, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 6 X 7=378
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC35A4 [Title/Abstract] AND PEX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-5892-01ASLC35A4chr5

139948680

+PEX1chr7

92146729

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000323146ENST00000438045SLC35A4chr5

139948680

+PEX1chr7

92146729

-
3UTR-intronENST00000323146ENST00000248633SLC35A4chr5

139948680

+PEX1chr7

92146729

-
3UTR-intronENST00000323146ENST00000428214SLC35A4chr5

139948680

+PEX1chr7

92146729

-
3UTR-intronENST00000323146ENST00000541751SLC35A4chr5

139948680

+PEX1chr7

92146729

-
intron-intronENST00000508770ENST00000438045SLC35A4chr5

139948680

+PEX1chr7

92146729

-
intron-intronENST00000508770ENST00000248633SLC35A4chr5

139948680

+PEX1chr7

92146729

-
intron-intronENST00000508770ENST00000428214SLC35A4chr5

139948680

+PEX1chr7

92146729

-
intron-intronENST00000508770ENST00000541751SLC35A4chr5

139948680

+PEX1chr7

92146729

-
5CDS-intronENST00000514199ENST00000438045SLC35A4chr5

139948680

+PEX1chr7

92146729

-
5CDS-intronENST00000514199ENST00000248633SLC35A4chr5

139948680

+PEX1chr7

92146729

-
5CDS-intronENST00000514199ENST00000428214SLC35A4chr5

139948680

+PEX1chr7

92146729

-
5CDS-intronENST00000514199ENST00000541751SLC35A4chr5

139948680

+PEX1chr7

92146729

-

Top

FusionProtFeatures for SLC35A4_PEX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC35A4

Q96G79

PEX1

O43933


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLC35A4_PEX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLC35A4_PEX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC35A4MOV10, TRIM25, LMNAPEX1PEX26, PEX6, PPP2R1A, RELA, DTWD2, FAS, THBS3, FBXW11, HERC2, SMC1A, EXOSC2, DKKL1, FAM174A, ICAM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC35A4_PEX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SLC35A4_PEX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePEX1C0043459Zellweger Syndrome7CTD_human;ORPHANET;UNIPROT
TgenePEX1C0282527Infantile Refsum Disease (disorder)7ORPHANET;UNIPROT
TgenePEX1C1832200Peroxisome biogenesis disorders3CTD_human
TgenePEX1C1856186Deafness enamel hypoplasia nail defects1ORPHANET;UNIPROT