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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34326

FusionGeneSummary for SLC30A6_GNA11

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC30A6_GNA11
Fusion gene ID: 34326
HgeneTgene
Gene symbol

SLC30A6

GNA11

Gene ID

55676

2767

Gene namesolute carrier family 30 member 6G protein subunit alpha 11
SynonymsMST103|MSTP103|ZNT6FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2
Cytomap

2p22.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter 6solute carrier family 30 (zinc transporter), member 6guanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha
Modification date2018052220180523
UniProtAcc

Q6NXT4

P29992

Ensembl transtripts involved in fusion geneENST00000538303, ENST00000379343, 
ENST00000357055, ENST00000435660, 
ENST00000282587, ENST00000406369, 
ENST00000078429, ENST00000586180, 
Fusion gene scores* DoF score7 X 7 X 4=1962 X 2 X 2=8
# samples 73
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: SLC30A6 [Title/Abstract] AND GNA11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5754-01ASLC30A6chr2

32396442

+GNA11chr19

3110147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000538303ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
intron-intronENST00000538303ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+
Frame-shitENST00000379343ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
5CDS-intronENST00000379343ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+
5UTR-3CDSENST00000357055ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
5UTR-intronENST00000357055ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+
Frame-shitENST00000435660ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
5CDS-intronENST00000435660ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+
Frame-shitENST00000282587ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
5CDS-intronENST00000282587ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+
intron-3CDSENST00000406369ENST00000078429SLC30A6chr2

32396442

+GNA11chr19

3110147

+
intron-intronENST00000406369ENST00000586180SLC30A6chr2

32396442

+GNA11chr19

3110147

+

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FusionProtFeatures for SLC30A6_GNA11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC30A6

Q6NXT4

GNA11

P29992

Zinc-efflux transporter which allocates the cytoplasmiczinc to the trans-Golgi network (TGN) as well as the vesicularcompartment. {ECO:0000250}. Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. Acts as an activator of phospholipase C.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC30A6_GNA11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC30A6_GNA11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC30A6SLC30A5, RIC3, B3GNT3, CHRNA9, SPECC1L, HDGFRP3, ACTB, ACTBL2, MYO18A, C12orf43, TCTN3, TMEM17, TMEM216, SPPL2B, CSGALNACT2, KCNA5, TPRA1, FPR2, PMEL, FUT3, ST8SIA3GNA11MTNR1A, RGS3, EDNRA, EDNRB, ELAVL1, RGS14, GNB1, GNAS, CFTR, RGS13, SLC9A3R1, TBXA2R, PLCB1, CXCR5, ABCE1, SLC25A41, FBXL18, HOXB5, NUFIP1, PAPOLA, FYTTD1, TMEM185A, ATM, CCNL2, TMEM180, GNB2, GNB4, TMEM63B, DUSP9, GNG3, DUSP22, GNG4, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC30A6_GNA11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC30A6_GNA11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC30A6C0002395Alzheimer's Disease1CTD_human
TgeneGNA11C0220633Uveal melanoma3CTD_human;ORPHANET
TgeneGNA11C3809243HYPOCALCEMIA, AUTOSOMAL DOMINANT 22UNIPROT
TgeneGNA11C0018798Congenital Heart Defects1CTD_human
TgeneGNA11C0025202melanoma1CTD_human
TgeneGNA11C1840347HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder)1ORPHANET;UNIPROT