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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34322

FusionGeneSummary for SLC30A6_ACTR2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC30A6_ACTR2
Fusion gene ID: 34322
HgeneTgene
Gene symbol

SLC30A6

ACTR2

Gene ID

55676

10097

Gene namesolute carrier family 30 member 6ARP2 actin related protein 2 homolog
SynonymsMST103|MSTP103|ZNT6ARP2
Cytomap

2p22.3

2p14

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter 6solute carrier family 30 (zinc transporter), member 6actin-related protein 2actin-like protein 2
Modification date2018052220180519
UniProtAcc

Q6NXT4

P61160

Ensembl transtripts involved in fusion geneENST00000538303, ENST00000379343, 
ENST00000357055, ENST00000435660, 
ENST00000282587, ENST00000406369, 
ENST00000260641, ENST00000476840, 
ENST00000542850, ENST00000377982, 
Fusion gene scores* DoF score7 X 7 X 4=1964 X 3 X 2=24
# samples 73
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC30A6 [Title/Abstract] AND ACTR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACTR2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7312-01BSLC30A6chr2

32399216

+ACTR2chr2

65492177

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000538303ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000538303ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000538303ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000538303ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
Frame-shitENST00000379343ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000379343ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000379343ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000379343ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5UTR-3CDSENST00000357055ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5UTR-intronENST00000357055ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5UTR-intronENST00000357055ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5UTR-intronENST00000357055ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
Frame-shitENST00000435660ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000435660ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000435660ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000435660ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
Frame-shitENST00000282587ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000282587ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000282587ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
5CDS-intronENST00000282587ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
intron-3CDSENST00000406369ENST00000260641SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
intron-intronENST00000406369ENST00000476840SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
intron-intronENST00000406369ENST00000542850SLC30A6chr2

32399216

+ACTR2chr2

65492177

+
intron-intronENST00000406369ENST00000377982SLC30A6chr2

32399216

+ACTR2chr2

65492177

+

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FusionProtFeatures for SLC30A6_ACTR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC30A6

Q6NXT4

ACTR2

P61160

Zinc-efflux transporter which allocates the cytoplasmiczinc to the trans-Golgi network (TGN) as well as the vesicularcompartment. {ECO:0000250}. Functions as ATP-binding component of the Arp2/3 complexwhich is involved in regulation of actin polymerization andtogether with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the pointed end of the daughter actin filament.{ECO:0000269|PubMed:9000076}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC30A6_ACTR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC30A6_ACTR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC30A6SLC30A5, RIC3, B3GNT3, CHRNA9, SPECC1L, HDGFRP3, ACTB, ACTBL2, MYO18A, C12orf43, TCTN3, TMEM17, TMEM216, SPPL2B, CSGALNACT2, KCNA5, TPRA1, FPR2, PMEL, FUT3, ST8SIA3ACTR2ACTR3B, BAK1, ACTR3, BMP2, CTTN, ESR1, ACTB, UBC, ELAVL1, SIRT7, CUL3, LRRK2, ARPC1B, ARPC4, ARPC5, ARPC2, ARPC3, ARPC1A, ARPC5L, CORO1C, UBE2N, FN1, VCAM1, WASL, ELF5, ANP32B, BAG1, CALR, DHPS, EEF2K, EFTUD1, P3H1, OSGEP, TTLL12, ALAD, CALU, CRTAP, FUBP1, GRPEL1, HIST1H2AB, HSPBP1, KIAA1279, METTL1, NIF3L1, NSUN2, OGT, PANK4, PPME1, PRKACB, RANGAP1, RPA1, RPRD1A, RPRD1B, SH3GL1, SH3GLB1, SRP9, SURF2, TOM1L1, TP53RK, TPD52L2, TPRKB, UFM1, WDR4, ZPR1, CUL7, OBSL1, EGFR, UNK, CAPZA1, CCT5, CORO1A, EFHD2, PSMD7, STXBP1, ARPC4-TTLL3, CAPZA2, CORO1B, FAM98B, NTRK1, KRAS, PCM1, CEP170, CEP128, NIN, SCLT1, EVC2, STIL, XPO1, CCT6A, CFL1, CLTA, CLTB, DAB2, DBN1, DSG2, GSN, ITPR3, MYO6, PPP1R12A, SVIL, TCP1, CCT3, LUZP1, GPRC5A, FLNA, MYH9, PPP1CB, IQGAP1, ATP6AP2, SYNPO, ANLN, MYO5C, MYO19, MYO18A, BASP1, CCT7, CCT4, CCT2, CCT8, COBL, LIMA1, RBM27, METTL3, INF2, PDCL3, CYBRD1, CHURC1, SPECC1, MISP, FBXW7, SNW1, CDC5L, HSD17B10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC30A6_ACTR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC30A6_ACTR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC30A6C0002395Alzheimer's Disease1CTD_human
TgeneACTR2C0036341Schizophrenia1PSYGENET