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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34312

FusionGeneSummary for SLC2A6_WDR90

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A6_WDR90
Fusion gene ID: 34312
HgeneTgene
Gene symbol

SLC2A6

WDR90

Gene ID

11182

197335

Gene namesolute carrier family 2 member 6WD repeat domain 90
SynonymsGLUT6|GLUT9|HSA011372C16orf15|C16orf16|C16orf17|C16orf18|C16orf19
Cytomap

9q34.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 2, facilitated glucose transporter member 6GLUT-6GLUT-9glucose transporter type 6glucose transporter type 9solute carrier family 2 (facilitated glucose transporter), member 6WD repeat-containing protein 90
Modification date2018052320180519
UniProtAcc

Q9UGQ3

Q96KV7

Ensembl transtripts involved in fusion geneENST00000485978, ENST00000371897, 
ENST00000371899, 
ENST00000549091, 
ENST00000293879, ENST00000547543, 
ENST00000547944, ENST00000315764, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 24
** MAII scorelog2(2/1*10)=4.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC2A6 [Title/Abstract] AND WDR90 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP285361SLC2A6chr9

136343376

-WDR90chr16

705670

+
ChiTaRS3.1BP288564SLC2A6chr9

136343376

-WDR90chr16

705670

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000485978ENST00000549091SLC2A6chr9

136343376

-WDR90chr16

705670

+
5UTR-3CDSENST00000485978ENST00000293879SLC2A6chr9

136343376

-WDR90chr16

705670

+
5UTR-intronENST00000485978ENST00000547543SLC2A6chr9

136343376

-WDR90chr16

705670

+
5UTR-intronENST00000485978ENST00000547944SLC2A6chr9

136343376

-WDR90chr16

705670

+
5UTR-intronENST00000485978ENST00000315764SLC2A6chr9

136343376

-WDR90chr16

705670

+
Frame-shiftENST00000371897ENST00000549091SLC2A6chr9

136343376

-WDR90chr16

705670

+
Frame-shiftENST00000371897ENST00000293879SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371897ENST00000547543SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371897ENST00000547944SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371897ENST00000315764SLC2A6chr9

136343376

-WDR90chr16

705670

+
Frame-shiftENST00000371899ENST00000549091SLC2A6chr9

136343376

-WDR90chr16

705670

+
Frame-shiftENST00000371899ENST00000293879SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371899ENST00000547543SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371899ENST00000547944SLC2A6chr9

136343376

-WDR90chr16

705670

+
5CDS-intronENST00000371899ENST00000315764SLC2A6chr9

136343376

-WDR90chr16

705670

+

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FusionProtFeatures for SLC2A6_WDR90


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC2A6

Q9UGQ3

WDR90

Q96KV7

Facilitative glucose transporter; binds cytochalasin Bwith low affinity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC2A6_WDR90


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC2A6_WDR90


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC2A6_WDR90


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC2A6_WDR90


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource