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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34298

FusionGeneSummary for SLC2A13_FAM186A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A13_FAM186A
Fusion gene ID: 34298
HgeneTgene
Gene symbol

SLC2A13

FAM186A

Gene ID

114134

121006

Gene namesolute carrier family 2 member 13family with sequence similarity 186 member A
SynonymsHMIT-
Cytomap

12q12

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionproton myo-inositol cotransporterH(+)-myo-inositol symporterh(+)-myo-inositol cotransporterproton (H+) myo-inositol symportersolute carrier family 2 (facilitated glucose transporter), member 13protein FAM186A
Modification date2018052320180519
UniProtAcc

Q96QE2

A6NE01

Ensembl transtripts involved in fusion geneENST00000280871, ENST00000380858, 
ENST00000543096, ENST00000543111, 
ENST00000327337, 
Fusion gene scores* DoF score9 X 5 X 7=3153 X 2 X 2=12
# samples 73
** MAII scorelog2(7/315*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC2A13 [Title/Abstract] AND FAM186A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-WE-A8ZX-06ASLC2A13chr12

40499055

-FAM186Achr12

50727886

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000280871ENST00000543096SLC2A13chr12

40499055

-FAM186Achr12

50727886

-
Frame-shiftENST00000280871ENST00000543111SLC2A13chr12

40499055

-FAM186Achr12

50727886

-
Frame-shiftENST00000280871ENST00000327337SLC2A13chr12

40499055

-FAM186Achr12

50727886

-
Frame-shiftENST00000380858ENST00000543096SLC2A13chr12

40499055

-FAM186Achr12

50727886

-
Frame-shiftENST00000380858ENST00000543111SLC2A13chr12

40499055

-FAM186Achr12

50727886

-
Frame-shiftENST00000380858ENST00000327337SLC2A13chr12

40499055

-FAM186Achr12

50727886

-

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FusionProtFeatures for SLC2A13_FAM186A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC2A13

Q96QE2

FAM186A

A6NE01

H(+)-myo-inositol cotransporter. Can also transportrelated stereoisomers. {ECO:0000269|PubMed:11500374}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC2A13_FAM186A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC2A13_FAM186A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC2A13FAM186AEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC2A13_FAM186A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC2A13_FAM186A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC2A13C0236969Substance-Related Disorders1CTD_human