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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34279

FusionGeneSummary for SLC27A5_ESRRG

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC27A5_ESRRG
Fusion gene ID: 34279
HgeneTgene
Gene symbol

SLC27A5

ESRRG

Gene ID

10998

2104

Gene namesolute carrier family 27 member 5estrogen related receptor gamma
SynonymsACSB|ACSVL6|BACS|BAL|FACVL3|FATP-5|FATP5|VLACSR|VLCS-H2|VLCSH2ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3
Cytomap

19q13.43

1q41

Type of geneprotein-codingprotein-coding
Descriptionbile acyl-CoA synthetaseBA-CoA ligaseVLACS-relatedbile acid-CoA ligasecholate--CoA ligasefatty acid transport protein 5fatty-acid-Coenzyme A ligase, very long-chain 3solute carrier family 27 (fatty acid transporter), member 5very long-chain acyl-Cestrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3
Modification date2018051920180519
UniProtAcc

Q9Y2P5

P62508

Ensembl transtripts involved in fusion geneENST00000594786, ENST00000599700, 
ENST00000263093, ENST00000601355, 
ENST00000361525, ENST00000366940, 
ENST00000361395, ENST00000366938, 
ENST00000359162, ENST00000493603, 
ENST00000463665, ENST00000487276, 
ENST00000493748, ENST00000471371, 
ENST00000391890, ENST00000366937, 
ENST00000408911, ENST00000360012, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC27A5 [Title/Abstract] AND ESRRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC27A5

GO:0000038

very long-chain fatty acid metabolic process

10479480

HgeneSLC27A5

GO:0006699

bile acid biosynthetic process

11980911

TgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA457551SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000594786ENST00000361525SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000366940SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000361395SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000366938SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000359162SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000493603SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000463665SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000487276SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000493748SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000471371SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000391890SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000366937SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000408911SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000594786ENST00000360012SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000361525SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000366940SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000361395SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000366938SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000359162SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000493603SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000463665SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000487276SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000493748SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000471371SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000391890SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000366937SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000408911SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000599700ENST00000360012SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000361525SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000366940SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000361395SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000366938SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000359162SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000493603SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000463665SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000487276SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000493748SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000471371SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000391890SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000366937SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000408911SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000263093ENST00000360012SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000361525SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000366940SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000361395SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000366938SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000359162SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000493603SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000463665SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000487276SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000493748SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000471371SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000391890SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000366937SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000408911SLC27A5chr19

59015502

+ESRRGchr1

216730758

+
intron-intronENST00000601355ENST00000360012SLC27A5chr19

59015502

+ESRRGchr1

216730758

+

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FusionProtFeatures for SLC27A5_ESRRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC27A5

Q9Y2P5

ESRRG

P62508

Acyl-CoA synthetase involved in bile acid metabolism.Proposed to catalyze the first step in the conjugation of C24 bileacids (choloneates) to glycine and taurine before excretion intobile canaliculi by activating them to their CoA thioesters. Seemsto activate secondary bile acids entering the liver from theenterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27precursor of cholic acid deriving from the de novo synthesis fromcholesterol. {ECO:0000269|PubMed:10749848,ECO:0000269|PubMed:11980911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC27A5_ESRRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC27A5_ESRRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC27A5_ESRRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
TgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for SLC27A5_ESRRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource