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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34271

FusionGeneSummary for SLC26A4_NNMT

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC26A4_NNMT
Fusion gene ID: 34271
HgeneTgene
Gene symbol

SLC26A4

NNMT

Gene ID

5172

4837

Gene namesolute carrier family 26 member 4nicotinamide N-methyltransferase
SynonymsDFNB4|EVA|PDS|TDH2B-
Cytomap

7q22.3

11q23.2

Type of geneprotein-codingprotein-coding
Descriptionpendrinsodium-independent chloride/iodide transportersolute carrier family 26 (anion exchanger), member 4truncated solute carrier family 26nicotinamide N-methyltransferase
Modification date2018052320180523
UniProtAcc

O43511

P40261

Ensembl transtripts involved in fusion geneENST00000265715, ENST00000541474, 
ENST00000544569, ENST00000543100, 
ENST00000480841, 
ENST00000535401, 
ENST00000535185, ENST00000299964, 
ENST00000541754, ENST00000542647, 
ENST00000545255, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC26A4 [Title/Abstract] AND NNMT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-A6RC-01ASLC26A4chr7

107342502

+NNMTchr11

114133570

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265715ENST00000535401SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-3UTRENST00000265715ENST00000535185SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000265715ENST00000299964SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000265715ENST00000541754SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000265715ENST00000542647SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000265715ENST00000545255SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-5UTRENST00000541474ENST00000535401SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-3UTRENST00000541474ENST00000535185SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000541474ENST00000299964SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000541474ENST00000541754SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000541474ENST00000542647SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000541474ENST00000545255SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-5UTRENST00000544569ENST00000535401SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-3UTRENST00000544569ENST00000535185SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000544569ENST00000299964SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000544569ENST00000541754SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000544569ENST00000542647SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000544569ENST00000545255SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-5UTRENST00000543100ENST00000535401SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-3UTRENST00000543100ENST00000535185SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000543100ENST00000299964SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000543100ENST00000541754SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000543100ENST00000542647SLC26A4chr7

107342502

+NNMTchr11

114133570

+
5CDS-intronENST00000543100ENST00000545255SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-5UTRENST00000480841ENST00000535401SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-3UTRENST00000480841ENST00000535185SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-intronENST00000480841ENST00000299964SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-intronENST00000480841ENST00000541754SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-intronENST00000480841ENST00000542647SLC26A4chr7

107342502

+NNMTchr11

114133570

+
intron-intronENST00000480841ENST00000545255SLC26A4chr7

107342502

+NNMTchr11

114133570

+

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FusionProtFeatures for SLC26A4_NNMT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC26A4

O43511

NNMT

P40261

Sodium-independent transporter of chloride and iodide.{ECO:0000269|PubMed:10192399}. Catalyzes the N-methylation of nicotinamide and otherpyridines to form pyridinium ions. This activity is important forbiotransformation of many drugs and xenobiotic compounds.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC26A4_NNMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC26A4_NNMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC26A4NNMTAPP, ATF6, BMF, GLOD4, ADK, CRYZ, CDC73


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC26A4_NNMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNNMTP40261DB00627NiacinNicotinamide N-methyltransferasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SLC26A4_NNMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC26A4C0271829Pendred's syndrome22CTD_human;ORPHANET;UNIPROT
HgeneSLC26A4C3538946DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT17CTD_human;UNIPROT
HgeneSLC26A4C0018021Goiter3CTD_human;HPO
HgeneSLC26A4C0018784Sensorineural Hearing Loss (disorder)3CTD_human;HPO
HgeneSLC26A4C0033578Prostatic Neoplasms1CTD_human
HgeneSLC26A4C1384666hearing impairment1CTD_human
TgeneNNMTC0036341Schizophrenia2PSYGENET
TgeneNNMTC0005586Bipolar Disorder1PSYGENET